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Acsm2 acyl-CoA synthetase medium-chain family member 2 [ Mus musculus (house mouse) ]

Gene ID: 233799, updated on 28-Oct-2024

Summary

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Official Symbol
Acsm2provided by MGI
Official Full Name
acyl-CoA synthetase medium-chain family member 2provided by MGI
Primary source
MGI:MGI:2385289
See related
Ensembl:ENSMUSG00000030945 AllianceGenome:MGI:2385289
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable benzoate-CoA ligase activity; fatty-acyl-CoA synthase activity; and medium-chain fatty acid-CoA ligase activity. Predicted to be involved in acyl-CoA metabolic process and fatty acid biosynthetic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; cranium; genitourinary system; and integumental system. Orthologous to human ACSM2A (acyl-CoA synthetase medium chain family member 2A) and ACSM2B (acyl-CoA synthetase medium chain family member 2B). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Restricted expression toward kidney adult (RPKM 70.4) See more
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Genomic context

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See Acsm2 in Genome Data Viewer
Location:
7 F2; 7 63.97 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (119153563..119199917)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (119554340..119600694)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene uromodulin Neighboring gene protein disulfide isomerase-like, testis expressed Neighboring gene acyl-CoA synthetase medium-chain family member 5 Neighboring gene predicted gene, 39078 Neighboring gene predicted gene, 39079 Neighboring gene acyl-CoA synthetase medium-chain family member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression of Acsm2, a kidney-specific gene, parallels the function and maturation of proximal tubular cells. Watanabe H, et al. Am J Physiol Renal Physiol, 2020 Oct 1. PMID 32830538, Free PMC Article
  2. Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans. Calvo SE, et al. Proc Natl Acad Sci U S A, 2009 May 5. PMID 19372376, Free PMC Article
  3. Short-chain 3-hydroxyacyl-coenzyme A dehydrogenase associates with a protein super-complex integrating multiple metabolic pathways. Narayan SB, et al. PLoS One, 2012. PMID 22496890, Free PMC Article
  4. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression of Acsm2, a kidney-specific gene, parallels the function and maturation of proximal tubular cells.
    Title: Expression of Acsm2, a kidney-specific gene, parallels the function and maturation of proximal tubular cells.
  2. Includes the study of an upstream ORF in this gene, and shows that it functions to reduce protein levels by ~50%.
    Title: Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC37245

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables benzoate-CoA ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables benzoate-CoA ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables decanoate-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables fatty acid ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fatty-acyl-CoA synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables medium-chain fatty acid-CoA ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in acyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
acyl-coenzyme A synthetase ACSM2, mitochondrial
Names
benzoate--CoA ligase
butyrate--CoA ligase 2
butyryl-coenzyme A synthetase 2
middle-chain acyl-CoA synthetase 2
NP_001171448.1
NP_001171449.1
NP_666309.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177977.1 → NP_001171448.1  acyl-coenzyme A synthetase ACSM2, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_001171448.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC134587, AK140827, AK165449
    Consensus CDS
    CCDS52379.1
    UniProtKB/Swiss-Prot
    Q8K0L3
    Related
    ENSMUSP00000095690.4, ENSMUST00000098084.11
    Conserved Domains (2) summary
    COG0365
    Location:65 → 591
    Acs; Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase [Lipid transport and metabolism]
    cl17068
    Location:66 → 594
    AFD_class_I; Adenylate forming domain, Class I superfamily

  2. NM_001177978.1 → NP_001171449.1  acyl-coenzyme A synthetase ACSM2, mitochondrial isoform 2

    See identical proteins and their annotated locations for NP_001171449.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, uses a downstream start codon, and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AC125147, AC134587, AK165401, AK165449
    Consensus CDS
    CCDS52380.1
    UniProtKB/Swiss-Prot
    Q8K0L3
    Related
    ENSMUSP00000081697.7, ENSMUST00000084647.13
    Conserved Domains (2) summary
    COG0365
    Location:40 → 571
    Acs; Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase [Lipid transport and metabolism]
    cl17068
    Location:41 → 574
    AFD_class_I; Adenylate forming domain, Class I superfamily

  3. NM_146197.4 → NP_666309.1  acyl-coenzyme A synthetase ACSM2, mitochondrial isoform 3

    See identical proteins and their annotated locations for NP_666309.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon, compared to variant 1. The encoded isoform (3) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AC125147, AC134587, AK165353, AK165449
    Consensus CDS
    CCDS21782.1
    UniProtKB/Swiss-Prot
    Q3TNC6, Q3US47, Q8K0L3, Q8R1L3, Q96LX4
    Related
    ENSMUSP00000126670.4, ENSMUST00000167935.10
    Conserved Domains (1) summary
    cl17068
    Location:41 → 569
    AFD_class_I; Adenylate forming domain, Class I superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    119153563..119199917
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K0L3.1 GenPept UniProtKB/Swiss-Prot:Q8K0L3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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