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Vwa3a von Willebrand factor A domain containing 3A [ Mus musculus (house mouse) ]

Gene ID: 233813, updated on 28-Oct-2024

Summary

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Official Symbol
Vwa3aprovided by MGI
Official Full Name
von Willebrand factor A domain containing 3Aprovided by MGI
Primary source
MGI:MGI:3041229
See related
Ensembl:ENSMUSG00000030889 AllianceGenome:MGI:3041229
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
E030013G06Rik
Summary
Is expressed in 4th ventricle; choroid plexus; and lateral ventricle choroid plexus. Orthologous to human VWA3A (von Willebrand factor A domain containing 3A). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in testis adult (RPKM 12.2), lung adult (RPKM 1.7) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Vwa3a in Genome Data Viewer
Location:
7 F2; 7 64.9 cM
Exon count:
37
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (120336554..120404769)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (120737331..120805546)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene ubiquinol cytochrome c reductase core protein 2 Neighboring gene PDZ domain containing 9 Neighboring gene modulator of smoothened Neighboring gene predicted gene, 57518 Neighboring gene short chain dehydrogenase/reductase family 42E, member 2 Neighboring gene STARR-positive B cell enhancer ABC_E6592 Neighboring gene nuclear encoded tRNA leucine 1 (anticodon TAG)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
  2. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
von Willebrand factor A domain-containing protein 3A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177697.3 → NP_808365.2  von Willebrand factor A domain-containing protein 3A

    See identical proteins and their annotated locations for NP_808365.2

    Status: VALIDATED

    Source sequence(s)
    AC099930, AC122214
    Consensus CDS
    CCDS40112.1
    UniProtKB/Swiss-Prot
    Q3UVV9, Q8C349
    Related
    ENSMUSP00000033180.7, ENSMUST00000033180.13
    Conserved Domains (1) summary
    cl00057
    Location:142 → 297
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    120336554..120404769
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241753.3 → XP_011240055.1  von Willebrand factor A domain-containing protein 3A isoform X1

    See identical proteins and their annotated locations for XP_011240055.1

    Conserved Domains (1) summary
    cl00057
    Location:142 → 297
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  2. XM_030242509.1 → XP_030098369.1  von Willebrand factor A domain-containing protein 3A isoform X1

    Conserved Domains (1) summary
    cl00057
    Location:142 → 297
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  3. XM_030242510.2 → XP_030098370.1  von Willebrand factor A domain-containing protein 3A isoform X2

    UniProtKB/Swiss-Prot
    Q3UVV9, Q8C349
    Related
    ENSMUSP00000129136.2, ENSMUST00000166668.9
    Conserved Domains (1) summary
    cl00057
    Location:142 → 297
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  4. XM_030242511.2 → XP_030098371.1  von Willebrand factor A domain-containing protein 3A isoform X2

    UniProtKB/Swiss-Prot
    Q3UVV9, Q8C349
    Related
    ENSMUSP00000133029.2, ENSMUST00000167213.9
    Conserved Domains (1) summary
    cl00057
    Location:142 → 297
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  5. XM_030242512.2 → XP_030098372.1  von Willebrand factor A domain-containing protein 3A isoform X2

    UniProtKB/Swiss-Prot
    Q3UVV9, Q8C349
    Conserved Domains (1) summary
    cl00057
    Location:142 → 297
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  6. XM_011241752.4 → XP_011240054.1  von Willebrand factor A domain-containing protein 3A isoform X1

    See identical proteins and their annotated locations for XP_011240054.1

    Conserved Domains (1) summary
    cl00057
    Location:142 → 297
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  7. XM_006507690.5 → XP_006507753.1  von Willebrand factor A domain-containing protein 3A isoform X1

    See identical proteins and their annotated locations for XP_006507753.1

    Conserved Domains (1) summary
    cl00057
    Location:142 → 297
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  8. XM_011241754.2 → XP_011240056.1  von Willebrand factor A domain-containing protein 3A isoform X3

    Conserved Domains (1) summary
    cl00057
    Location:74 → 229
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  9. XM_030242513.1 → XP_030098373.1  von Willebrand factor A domain-containing protein 3A isoform X4

    Conserved Domains (1) summary
    cl00057
    Location:580 → 733
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

RNA

  1. XR_378236.5 RNA Sequence

    Related
    ENSMUST00000168600.9
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UVV9.1 GenPept UniProtKB/Swiss-Prot:Q3UVV9

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