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FNTA farnesyltransferase, CAAX box, subunit alpha [ Homo sapiens (human) ]

Gene ID: 2339, updated on 2-Nov-2024

Summary

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Official Symbol
FNTAprovided by HGNC
Official Full Name
farnesyltransferase, CAAX box, subunit alphaprovided by HGNC
Primary source
HGNC:HGNC:3782
See related
Ensembl:ENSG00000168522 MIM:134635; AllianceGenome:HGNC:3782
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FPTA; PTAR2; PGGT1A
Summary
Prenyltransferases can attach either a farnesyl group or a geranylgeranyl group in thioether linkage to the cysteine residue of proteins with a C-terminal CAAX box. CAAX geranylgeranyltransferase and CAAX farnesyltransferase are heterodimers that share the same alpha subunit but have different beta subunits. This gene encodes the alpha subunit of these transferases. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq, May 2010]
Expression
Ubiquitous expression in fat (RPKM 32.7), placenta (RPKM 27.4) and 25 other tissues See more
Orthologs
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Genomic context

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See FNTA in Genome Data Viewer
Location:
8p11.21
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (43056323..43085785)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (43325268..43354718)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (42911466..42940928)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ring finger protein 170 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:42750865-42751426 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19160 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19161 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:42774215-42774934 Neighboring gene microRNA 4469 Neighboring gene hook microtubule tethering protein 3 Neighboring gene MPRA-validated peak7007 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:42888473-42889024 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27320 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19162 Neighboring gene RNA, U1 small nuclear 124, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27321 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:42947622-42948528 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:42948529-42949434 Neighboring gene NANOG hESC enhancer GRCh37_chr8:42971985-42972543 Neighboring gene protein O-mannose kinase Neighboring gene Sharpr-MPRA regulatory region 5985 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19164 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19165 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19166 Neighboring gene heparan-alpha-glucosaminide N-acetyltransferase Neighboring gene RNY5 pseudogene 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Inhibition of Farnesyltransferase Potentiates NOTCH-Targeted Therapy against Glioblastoma Stem Cells. Ma Y, et al. Stem Cell Reports, 2017 Dec 12. PMID 29198824, Free PMC Article
  2. Mutational analysis of alpha-subunit of protein farnesyltransferase. Evidence for a catalytic role. Andres DA, et al. J Biol Chem, 1993 Jan 15. PMID 8419339
  3. 3-Aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency. Bell IM, et al. J Med Chem, 2002 Jun 6. PMID 12036349
  4. The processing pathway of prelamin A. Sinensky M, et al. J Cell Sci, 1994 Jan. PMID 8175923
  5. Dual protein farnesyltransferase-geranylgeranyltransferase-I inhibitors as potential cancer chemotherapeutic agents. deSolms SJ, et al. J Med Chem, 2003 Jul 3. PMID 12825937

See all (70) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Protein farnesylation is upregulated in Alzheimer's human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer's model mice.
    Title: Protein farnesylation is upregulated in Alzheimer's human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer's model mice.
  2. Cell-permeable CaaX-peptides affect K-Ras downstream signaling and promote cell death in cancer cells.
    Title: Cell-permeable CaaX-peptides affect K-Ras downstream signaling and promote cell death in cancer cells.
  3. Scaffold association factor B (SAFB) is required for expression of prenyltransferases and RAS membrane association.
    Title: Scaffold association factor B (SAFB) is required for expression of prenyltransferases and RAS membrane association.
  4. These findings collectively suggest that the combination of farnesyltransferase inhibitors and gamma-secretase inhibitors is a promising therapeutic strategy for glioblastoma through selectively targeting the cancer stem cell subpopulation.
    Title: Inhibition of Farnesyltransferase Potentiates NOTCH-Targeted Therapy against Glioblastoma Stem Cells.
  5. Exploring the putative self-binding property of the human farnesyltransferase alpha-subunit
    Title: Exploring the putative self-binding property of the human farnesyltransferase alpha-subunit.
  6. our findings identify Geranylgeranyl transferase 1 as a key regulator of human airway smooth muscle cell viability
    Title: Geranylgeranyl transferase 1 modulates autophagy and apoptosis in human airway smooth muscle.
  7. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Genetic variation in 3-hydroxy-3-methylglutaryl CoA reductase modifies the chemopreventive activity of statins for colorectal cancer.
  8. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
    Title: Polymorphisms of the lamina maturation pathway and their association with the metabolic syndrome: the DESIR prospective study.
  9. FTase, via its tubulin-association, is a critical upstream regulator of HDAC6 activity
    Title: The protein farnesyltransferase regulates HDAC6 activity in a microtubule-dependent manner.
  10. Results suggest that all peptide substrates adopt a common binding mode in the protein farnesyltransferase and geranylgeranyltransferase active site.
    Title: Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of farnesyltransferase, CAAX box, alpha (FNTA) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Geranylgeranyltransferase-1 modulates both p24CA release and intracellular Gag in TNF-alpha-stimulated U1 cells PubMed
capsid gag Geranylgeranyltransferase-1 modulates both p24CA release and intracellular Gag in TNF-alpha-stimulated U1 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC99680

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to CAAX-protein geranylgeranyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Rab geranylgeranyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables alpha-tubulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables molecular adaptor activity EXP
Inferred from Experiment
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
contributes_to protein farnesyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to protein farnesyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein farnesyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein geranylgeranyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables receptor tyrosine kinase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in peptide pheromone maturation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of Rac protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of deacetylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of skeletal muscle acetylcholine-gated channel clustering IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of tubulin deacetylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein farnesylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein geranylgeranylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in skeletal muscle acetylcholine-gated channel clustering IEA
Inferred from Electronic Annotation
more info
  
involved_in transforming growth factor beta receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of CAAX-protein geranylgeranyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of CAAX-protein geranylgeranyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of CAAX-protein geranylgeranyltransferase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of microtubule associated complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of protein farnesyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein farnesyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Names
FTase-alpha
GGTase-I-alpha
farnesyl-protein transferase alpha-subunit
farnesyltransferase, CAAX box, alpha
protein prenyltransferase alpha subunit repeat containing 2
ras proteins prenyltransferase subunit alpha
type I protein geranyl-geranyltransferase alpha subunit
NP_002018.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002027.3 → NP_002018.1  protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

    See identical proteins and their annotated locations for NP_002018.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.
    Source sequence(s)
    BC084566, BI913631
    Consensus CDS
    CCDS6140.1
    UniProtKB/Swiss-Prot
    A6NJW0, P49354, Q53XJ9, Q9UDC1
    Related
    ENSP00000303423.3, ENST00000302279.8
    Conserved Domains (1) summary
    PLN02789
    Location:64 → 365
    PLN02789; farnesyltranstransferase

RNA

  1. NR_033698.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate internal exon in the 5' region, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC084566, BI913631, BM686906

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    43056323..43085785
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    43325268..43354718
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001018676.1: Suppressed sequence

    Description
    NM_001018676.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

  2. NM_001018677.1: Suppressed sequence

    Description
    NM_001018677.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P49354.1 GenPept UniProtKB/Swiss-Prot:P49354

Gene LinkOut

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