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Ppfia1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 [ Mus musculus (house mouse) ]

Gene ID: 233977, updated on 28-Oct-2024

Summary

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Official Symbol
Ppfia1provided by MGI
Official Full Name
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1provided by MGI
Primary source
MGI:MGI:1924750
See related
Ensembl:ENSMUSG00000037519 AllianceGenome:MGI:1924750
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LIP1; LIP.1; C030014K08Rik
Summary
Acts upstream of or within negative regulation of stress fiber assembly. Predicted to be located in several cellular components, including axon; dendrite; and focal adhesion. Predicted to be part of protein-containing complex. Predicted to be active in Schaffer collateral - CA1 synapse; presynaptic active zone; and spine apparatus. Is expressed in several structures, including blood vessel endothelium; central nervous system; genitourinary system; retina; and spleen. Orthologous to human PPFIA1 (PTPRF interacting protein alpha 1). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in cerebellum adult (RPKM 13.1), CNS E11.5 (RPKM 12.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ppfia1 in Genome Data Viewer
Location:
7 F5; 7 88.85 cM
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (144030492..144107497, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (144476755..144553762, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34561 Neighboring gene cortactin Neighboring gene STARR-positive B cell enhancer ABC_E6619 Neighboring gene STARR-positive B cell enhancer ABC_E9306 Neighboring gene predicted gene, 35626 Neighboring gene Fas associated via death domain Neighboring gene anoctamin 1, calcium activated chloride channel Neighboring gene RIKEN cDNA D930030F02 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification and characterization of mouse Ppfia1 gene in silico. Katoh M, et al. Int J Mol Med, 2003 Aug. PMID 12851729
  2. Cdk5-dependent phosphorylation of liprinα1 mediates neuronal activity-dependent synapse development. Huang H, et al. Proc Natl Acad Sci U S A, 2017 Aug 15. PMID 28760951, Free PMC Article
  3. Liprin-α-1 is a novel component of the murine neuromuscular junction and is involved in the organization of the postsynaptic machinery. Bernadzki KM, et al. Sci Rep, 2017 Aug 22. PMID 28831123, Free PMC Article
  4. Liprin-α controls stress fiber formation by binding to mDia and regulating its membrane localization. Sakamoto S, et al. J Cell Sci, 2012 Jan 1. PMID 22266902
  5. The mouse and human Liprin-alpha family of scaffolding proteins: genomic organization, expression profiling and regulation by alternative splicing. Zürner M, et al. Genomics, 2009 Mar. PMID 19013515

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. we found that liprin-alpha-1 plays an important role in AChR clustering and the organization of cortical microtubules. Our studies provide novel insights into the function of liprin-alpha-1 at vertebrate neuromuscular synapses.
    Title: Liprin-α-1 is a novel component of the murine neuromuscular junction and is involved in the organization of the postsynaptic machinery.
  2. findings collectively demonstrate that the Cdk5-dependent phosphorylation of liprinalpha1 is important for the postsynaptic organization during activity-dependent synapse development.
    Title: Cdk5-dependent phosphorylation of liprinα1 mediates neuronal activity-dependent synapse development.
  3. results suggested that PPFIA1 functioned with PP2A to promote the dephosphorylation of Kif7, triggering Kif7 localization to the tips of primary cilia and promoting Gli transcriptional activity.
    Title: The PPFIA1-PP2A protein complex promotes trafficking of Kif7 to the ciliary tip and Hedgehog signaling.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC189815, MGC189929

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of stress fiber assembly IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels ISO
Inferred from Sequence Orthology
more info
  
involved_in synapse organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse ISO
Inferred from Sequence Orthology
more info
  
located_in axon ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynaptic active zone IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in spine apparatus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
liprin-alpha-1
Names
Liprin-alpha1
liprin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033319.2 → NP_001028491.1  liprin-alpha-1 isoform B

    See identical proteins and their annotated locations for NP_001028491.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (B) lacks an in-frame exon in the 5' coding region, compared to variant A. The resulting protein (isoform B) is shorter than isoform A.
    Source sequence(s)
    AC140268, AC153792
    Consensus CDS
    CCDS52464.1
    UniProtKB/TrEMBL
    B2RXW8, B8QI33
    Related
    ENSMUSP00000126233.3, ENSMUST00000168134.10
    Conserved Domains (7) summary
    cd09562
    Location:884 → 954
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:1001 → 1066
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:1086 → 1157
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    smart00454
    Location:1087 → 1157
    SAM; Sterile alpha motif
    COG1842
    Location:302 → 515
    PspA; Phage shock protein A [Transcription, Signal transduction mechanisms]
    cl03951
    Location:406 → 514
    CDC37_N; Cdc37 N terminal kinase binding
    cl12013
    Location:323 → 444
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  2. NM_001195086.1 → NP_001182015.1  liprin-alpha-1 isoform A

    See identical proteins and their annotated locations for NP_001182015.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (A) represents the longer transcript and encodes the longer isoform (A).
    Source sequence(s)
    AC140268, AC153792
    Consensus CDS
    CCDS59738.1
    UniProtKB/TrEMBL
    B2RXQ2, B8QI33
    Related
    ENSMUSP00000138312.2, ENSMUST00000182226.8
    Conserved Domains (7) summary
    cd09562
    Location:909 → 979
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:1026 → 1091
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:1111 → 1182
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    smart00454
    Location:1112 → 1182
    SAM; Sterile alpha motif
    COG1842
    Location:302 → 540
    PspA; Phage shock protein A [Transcription, Signal transduction mechanisms]
    pfam00836
    Location:406 → 523
    Stathmin; Stathmin family
    cl12013
    Location:323 → 469
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    144030492..144107497 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508610.4 → XP_006508673.1  liprin-alpha-1 isoform X22

    UniProtKB/TrEMBL
    B8QI33
    Conserved Domains (5) summary
    cd09562
    Location:874 → 944
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:961 → 1026
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:1046 → 1117
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    COG1196
    Location:171 → 516
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02169
    Location:412 → 663
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  2. XM_017322222.3 → XP_017177711.1  liprin-alpha-1 isoform X16

    UniProtKB/TrEMBL
    B8QI33
    Conserved Domains (5) summary
    cd09562
    Location:874 → 944
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:991 → 1056
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:1076 → 1147
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    COG1196
    Location:171 → 516
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02169
    Location:412 → 663
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  3. XM_036153023.1 → XP_036008916.1  liprin-alpha-1 isoform X10

    UniProtKB/TrEMBL
    B8QI33
    Conserved Domains (5) summary
    cd09562
    Location:874 → 944
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:1012 → 1077
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:1097 → 1168
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    COG1196
    Location:171 → 516
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02169
    Location:389 → 660
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  4. XM_011241995.4 → XP_011240297.1  liprin-alpha-1 isoform X6

    UniProtKB/TrEMBL
    B8QI33
    Conserved Domains (5) summary
    cd09562
    Location:884 → 954
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:1022 → 1087
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:1107 → 1178
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    COG1196
    Location:171 → 516
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02169
    Location:412 → 663
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  5. XM_006508609.5 → XP_006508672.1  liprin-alpha-1 isoform X19

    UniProtKB/TrEMBL
    B8QI33
    Conserved Domains (5) summary
    cd09562
    Location:899 → 969
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:986 → 1051
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:1071 → 1142
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    COG1196
    Location:45 → 418
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:246 → 545
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  6. XM_017322223.3 → XP_017177712.1  liprin-alpha-1 isoform X18

    UniProtKB/TrEMBL
    B8QI33
    Conserved Domains (5) summary
    cd09562
    Location:899 → 969
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:987 → 1052
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:1072 → 1143
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    COG1196
    Location:45 → 418
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:246 → 545
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  7. XM_017322220.3 → XP_017177709.1  liprin-alpha-1 isoform X8

    UniProtKB/TrEMBL
    B8QI33
    Conserved Domains (5) summary
    cd09562
    Location:899 → 969
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:1016 → 1081
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:1101 → 1172
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    COG1196
    Location:45 → 418
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:246 → 545
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  8. XM_011241991.4 → XP_011240293.1  liprin-alpha-1 isoform X2

    UniProtKB/TrEMBL
    B8QI33
    Conserved Domains (5) summary
    cd09562
    Location:899 → 969
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:1037 → 1102
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:1122 → 1193
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    COG1196
    Location:45 → 418
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:246 → 545
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  9. XM_036153025.1 → XP_036008918.1  liprin-alpha-1 isoform X20

    UniProtKB/TrEMBL
    B8QI33
    Conserved Domains (6) summary
    cd09562
    Location:909 → 979
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:996 → 1061
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:1081 → 1152
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    COG1196
    Location:45 → 418
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:246 → 545
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR02169
    Location:421 → 685
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  10. XM_006508608.5 → XP_006508671.1  liprin-alpha-1 isoform X15

    UniProtKB/TrEMBL
    B8QI33
    Conserved Domains (5) summary
    cd09562
    Location:909 → 979
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:996 → 1061
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:1081 → 1152
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    COG1196
    Location:45 → 418
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:246 → 545
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  11. XM_006508607.5 → XP_006508670.1  liprin-alpha-1 isoform X14

    UniProtKB/TrEMBL
    B8QI33
    Conserved Domains (5) summary
    cd09562
    Location:909 → 979
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:997 → 1062
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:1082 → 1153
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    COG1196
    Location:45 → 418
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:246 → 545
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  12. XM_006508605.5 → XP_006508668.1  liprin-alpha-1 isoform X13

    UniProtKB/TrEMBL
    B8QI33
    Conserved Domains (5) summary
    cd09562
    Location:909 → 979
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:1005 → 1070
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:1090 → 1161
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    COG1196
    Location:45 → 418
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:246 → 545
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  13. XM_006508603.5 → XP_006508666.1  liprin-alpha-1 isoform X11

    UniProtKB/TrEMBL
    B8QI33
    Conserved Domains (5) summary
    cd09562
    Location:909 → 979
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:1006 → 1071
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:1091 → 1162
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    COG1196
    Location:45 → 418
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:246 → 545
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  14. XM_006508599.5 → XP_006508662.1  liprin-alpha-1 isoform X5

    UniProtKB/TrEMBL
    B8QI33
    Conserved Domains (5) summary
    cd09562
    Location:909 → 979
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:1026 → 1091
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:1111 → 1182
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    COG1196
    Location:45 → 418
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:246 → 545
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  15. XM_006508604.5 → XP_006508667.1  liprin-alpha-1 isoform X12

    UniProtKB/TrEMBL
    B8QI33
    Conserved Domains (5) summary
    cd09562
    Location:909 → 979
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:1017 → 1082
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:1102 → 1173
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    COG1196
    Location:45 → 418
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:246 → 545
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  16. XM_006508601.5 → XP_006508664.1  liprin-alpha-1 isoform X7

    UniProtKB/TrEMBL
    B8QI33
    Conserved Domains (5) summary
    cd09562
    Location:909 → 979
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:1017 → 1082
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:1102 → 1173
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    COG1196
    Location:45 → 418
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:246 → 545
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  17. XM_017322221.3 → XP_017177710.1  liprin-alpha-1 isoform X9

    UniProtKB/TrEMBL
    B8QI33
    Conserved Domains (5) summary
    cd09562
    Location:909 → 979
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:1027 → 1092
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:1112 → 1183
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    COG1196
    Location:45 → 418
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:246 → 545
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  18. XM_006508598.5 → XP_006508661.1  liprin-alpha-1 isoform X4

    UniProtKB/TrEMBL
    B8QI33
    Conserved Domains (5) summary
    cd09562
    Location:909 → 979
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:1027 → 1092
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:1112 → 1183
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    COG1196
    Location:45 → 418
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:246 → 545
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  19. XM_011241992.4 → XP_011240294.1  liprin-alpha-1 isoform X3

    UniProtKB/TrEMBL
    B8QI33
    Conserved Domains (5) summary
    cd09562
    Location:909 → 979
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:1047 → 1112
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:1132 → 1203
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    COG1196
    Location:45 → 418
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:246 → 545
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  20. XM_030242539.2 → XP_030098399.1  liprin-alpha-1 isoform X23

    UniProtKB/TrEMBL
    B8QI33
    Conserved Domains (5) summary
    cd09562
    Location:874 → 944
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:962 → 1027
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:1047 → 1118
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    COG1196
    Location:171 → 516
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02169
    Location:412 → 663
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  21. XM_006508612.4 → XP_006508675.1  liprin-alpha-1 isoform X26

    UniProtKB/TrEMBL
    B8QI33
    Conserved Domains (5) summary
    cd09562
    Location:884 → 954
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:992 → 1057
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:1077 → 1148
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    COG1196
    Location:171 → 516
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02169
    Location:412 → 663
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  22. XM_011241996.4 → XP_011240298.1  liprin-alpha-1 isoform X1

    See identical proteins and their annotated locations for XP_011240298.1

    UniProtKB/TrEMBL
    B8QI33
    Conserved Domains (5) summary
    cd09562
    Location:909 → 979
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:1047 → 1112
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:1132 → 1203
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    COG1196
    Location:45 → 418
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:246 → 545
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  23. XM_011241997.2 → XP_011240299.1  liprin-alpha-1 isoform X25

    Conserved Domains (3) summary
    cd09562
    Location:256 → 326
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:394 → 459
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:479 → 550
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3

  24. XM_006508611.4 → XP_006508674.1  liprin-alpha-1 isoform X24

    UniProtKB/TrEMBL
    B8QI33
    Conserved Domains (5) summary
    cd09562
    Location:874 → 944
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:961 → 1026
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:1046 → 1117
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    COG1196
    Location:171 → 516
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02169
    Location:412 → 663
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  25. XM_017322224.3 → XP_017177713.1  liprin-alpha-1 isoform X21

    UniProtKB/TrEMBL
    B8QI33
    Conserved Domains (5) summary
    cd09562
    Location:899 → 969
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:986 → 1051
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:1071 → 1142
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    COG1196
    Location:45 → 418
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:246 → 545
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  26. XM_036153024.1 → XP_036008917.1  liprin-alpha-1 isoform X17

    UniProtKB/TrEMBL
    B8QI33
    Conserved Domains (6) summary
    cd09562
    Location:909 → 979
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:1047 → 1112
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:1132 → 1203
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    COG1196
    Location:45 → 418
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:246 → 545
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR02169
    Location:421 → 685
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
Nucleotide Protein Strain
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