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Gpm6a glycoprotein m6a [ Mus musculus (house mouse) ]

Gene ID: 234267, updated on 28-Oct-2024

Summary

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Official Symbol
Gpm6aprovided by MGI
Official Full Name
glycoprotein m6aprovided by MGI
Primary source
MGI:MGI:107671
See related
Ensembl:ENSMUSG00000031517 AllianceGenome:MGI:107671
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
M6A; Gpm6
Summary
Predicted to enable calcium channel activity. Involved in neural retina development and neuron projection morphogenesis. Acts upstream of or within response to bacterium. Located in axonal growth cone. Is expressed in central nervous system; intraembryonic coelom; metanephros; sensory organ; and upper lip. Orthologous to human GPM6A (glycoprotein M6A). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in cortex adult (RPKM 193.1), frontal lobe adult (RPKM 175.9) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Gpm6a in Genome Data Viewer
Location:
8 B1.3; 8 29.33 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (55232469..55513913)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (54779434..55060878)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_21499 Neighboring gene spermatogenesis associated 4 Neighboring gene STARR-seq mESC enhancer starr_21500 Neighboring gene WD repeat domain 17 Neighboring gene STARR-seq mESC enhancer starr_21502 Neighboring gene predicted gene, 53418 Neighboring gene STARR-seq mESC enhancer starr_21503 Neighboring gene predicted gene, 57523 Neighboring gene STARR-seq mESC enhancer starr_21505 Neighboring gene STARR-positive B cell enhancer mm9_chr8:56197740-56198041 Neighboring gene STARR-positive B cell enhancer mm9_chr8:56199056-56199356 Neighboring gene a disintegrin and metallopeptidase domain 39 pseudogene Neighboring gene predicted gene, 53425

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Actin-independent behavior and membrane deformation exhibited by the four-transmembrane protein M6a. Sato Y, et al. PLoS One, 2011. PMID 22162747, Free PMC Article
  2. Sperm Rhoa m6A modification mediates intergenerational transmission of paternally acquired hippocampal neuronal senescence and cognitive deficits after combined exposure to environmental cadmium and high-fat diet in mice. Zhang J, et al. J Hazard Mater, 2023 Sep 15. PMID 37354721
  3. Isolation and mapping of the human glycoprotein M6 gene (GPM6A) to 4q33-->q34. Shimizu F, et al. Cytogenet Cell Genet, 1996. PMID 8893821
  4. SILENCING M 6 A READER YTHDC1 REDUCES INFLAMMATORY RESPONSE IN SEPSIS-INDUCED CARDIOMYOPATHY BY INHIBITING SERPINA3N EXPRESSION. Xie W, et al. Shock, 2023 May 1. PMID 36877222
  5. Extracellular Signals Induce Glycoprotein M6a Clustering of Lipid Rafts and Associated Signaling Molecules. Honda A, et al. J Neurosci, 2017 Apr 12. PMID 28275160, Free PMC Article

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sperm Rhoa m6A modification mediates intergenerational transmission of paternally acquired hippocampal neuronal senescence and cognitive deficits after combined exposure to environmental cadmium and high-fat diet in mice.
    Title: Sperm Rhoa m6A modification mediates intergenerational transmission of paternally acquired hippocampal neuronal senescence and cognitive deficits after combined exposure to environmental cadmium and high-fat diet in mice.
  2. Mettl14-mediated m[6]A modification ensures the cell-cycle progression of late-born retinal progenitor cells.
    Title: Mettl14-mediated m(6)A modification ensures the cell-cycle progression of late-born retinal progenitor cells.
  3. SILENCING M 6 A READER YTHDC1 REDUCES INFLAMMATORY RESPONSE IN SEPSIS-INDUCED CARDIOMYOPATHY BY INHIBITING SERPINA3N EXPRESSION.
    Title: SILENCING M 6 A READER YTHDC1 REDUCES INFLAMMATORY RESPONSE IN SEPSIS-INDUCED CARDIOMYOPATHY BY INHIBITING SERPINA3N EXPRESSION.
  4. Comprehensive Analysis of Differential m6A RNA Methylomes in the Hippocampus of Cocaine-Conditioned Mice.
    Title: Comprehensive Analysis of Differential m6A RNA Methylomes in the Hippocampus of Cocaine-Conditioned Mice.
  5. GPM6a induces the clustering of lipid rafts and acts as a signal transducer that responds to extracellular signals.
    Title: Extracellular Signals Induce Glycoprotein M6a Clustering of Lipid Rafts and Associated Signaling Molecules.
  6. This study demonistrated that M6a is essential for the support of neurite extension in developmental brain.
    Title: Transcallosal Projections Require Glycoprotein M6-Dependent Neurite Growth and Guidance.
  7. analysis of actin-independent behavior and membrane deformation exhibited by the four-transmembrane protein M6a
    Title: Actin-independent behavior and membrane deformation exhibited by the four-transmembrane protein M6a.
  8. M6a-deficient axons grow actively but are not growth suppressed by antibodies bound to four-transmembrane actin-based glycoprotein M6a concentrated on the edge of the axon growth cone.
    Title: Induction of axon growth arrest without growth cone collapse through the N-terminal region of four-transmembrane glycoprotein M6a.
  9. These results suggest that M6a plays a role in retinal development by regulating neurites, and it may also function to modulate synaptic activities in the adult retina.
    Title: M6a is expressed in the murine neural retina and regulates neurite extension.
  10. expression of shRNA against GPM6A markedly reduced the expression of neuroectodermal-associated genes (OTX1, Lmx1b, En1, Pax2, Pax5, Sox1, Sox2, and Wnt1), and also the number of neural stem cells (NSC) derived from D3mshM6A cells
    Title: Inhibition of mouse GPM6A expression leads to decreased differentiation of neurons derived from mouse embryonic stem cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC38999

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium channel activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in neural retina development IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neuron migration ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron migration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuron projection morphogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of filopodium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of filopodium assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of synapse organization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of synapse organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to bacterium IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in stem cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in stem cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in synapse assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in synapse assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in axonal growth cone IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in axonal growth cone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in dendritic spine IEA
Inferred from Electronic Annotation
more info
  
is_active_in filopodium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in filopodium ISO
Inferred from Sequence Orthology
more info
  
located_in filopodium ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
  
located_in neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in parallel fiber to Purkinje cell synapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in parallel fiber to Purkinje cell synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in presynapse ISO
Inferred from Sequence Orthology
more info
  
located_in presynaptic active zone membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in presynaptic active zone membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
neuronal membrane glycoprotein M6-a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001253754.1 → NP_001240683.1  neuronal membrane glycoprotein M6-a isoform 2

    See identical proteins and their annotated locations for NP_001240683.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has a different segment for its 5' end which results in the use of an alternate start codon, compared to variant 1. The encoded protein (isoform 2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC109200, BC033357, CK623810, CX564488
    UniProtKB/TrEMBL
    Q8R1P3
    Conserved Domains (1) summary
    pfam01275
    Location:3 → 236
    Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)

  2. NM_001253756.1 → NP_001240685.1  neuronal membrane glycoprotein M6-a isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has a different segment in its 5' UTR and lacks an alternate exon in the 5' coding region, which results in the use of a downstream start codon, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AK081877, BC033357, BY247392, CD354193
    UniProtKB/Swiss-Prot
    P35802
    UniProtKB/TrEMBL
    Q542P2
    Conserved Domains (1) summary
    cl02417
    Location:1 → 148
    Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)

  3. NM_153581.6 → NP_705809.1  neuronal membrane glycoprotein M6-a isoform 1

    See identical proteins and their annotated locations for NP_705809.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform 1).
    Source sequence(s)
    AK081877, BC033357, BY247392
    Consensus CDS
    CCDS22310.1
    UniProtKB/Swiss-Prot
    P35802
    UniProtKB/TrEMBL
    Q542P2
    Related
    ENSMUSP00000033915.8, ENSMUST00000033915.9
    Conserved Domains (1) summary
    pfam01275
    Location:14 → 247
    Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    55232469..55513913
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35802.1 GenPept UniProtKB/Swiss-Prot:P35802

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