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Tmem161a transmembrane protein 161A [ Mus musculus (house mouse) ]

Gene ID: 234371, updated on 2-Nov-2024

Summary

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Official Symbol
Tmem161aprovided by MGI
Official Full Name
transmembrane protein 161Aprovided by MGI
Primary source
MGI:MGI:2384577
See related
Ensembl:ENSMUSG00000002342 AllianceGenome:MGI:2384577
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to be involved in several processes, including cellular response to UV; regulation of cellular response to stress; and response to retinoic acid. Predicted to be located in membrane. Is expressed in heart ventricle. Orthologous to human TMEM161A (transmembrane protein 161A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in adrenal adult (RPKM 47.3), ovary adult (RPKM 34.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tmem161a in Genome Data Viewer
Location:
8 B3.3; 8 34.15 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (70624979..70636331)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (70172329..70183681)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1102 Neighboring gene STARR-seq mESC enhancer starr_21765 Neighboring gene BLOC-1 related complex subunit 8 Neighboring gene myocyte enhancer factor 2B like Neighboring gene STARR-positive B cell enhancer ABC_E3776 Neighboring gene myocyte enhancer factor 2B Neighboring gene STARR-positive B cell enhancer ABC_E10504 Neighboring gene solute carrier family 25, member 42 Neighboring gene STARR-positive B cell enhancer ABC_E1103 Neighboring gene armadillo repeat containing 6 Neighboring gene STARR-positive B cell enhancer ABC_E8239 Neighboring gene SURP and G patch domain containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Tmem161a regulates bone formation and bone strength through the P38 MAPK pathway. Nagai T, et al. Sci Rep, 2023 Sep 5. PMID 37670024, Free PMC Article
  2. SRSF2 in Sertoli cells is essential for testicular development and spermatogenesis in mice. Xie X, et al. FASEB J, 2023 May. PMID 37039821
  3. Development of an efficient screening system to identify novel bone metabolism-related genes using the exchangeable gene trap mutagenesis mouse models. Kurogi S, et al. Sci Rep, 2017 Jan 20. PMID 28106071, Free PMC Article
  4. Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice. Nakahara M, et al. Mamm Genome, 2013 Jun. PMID 23604909
  5. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tmem161a regulates bone formation and bone strength through the P38 MAPK pathway.
    Title: Tmem161a regulates bone formation and bone strength through the P38 MAPK pathway.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC29210

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cellular response to UV IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to UV ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to oxidative stress IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA repair ISO
Inferred from Sequence Orthology
more info
  
involved_in response to retinoic acid IEA
Inferred from Electronic Annotation
more info
  
involved_in response to retinoic acid ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane protein 161A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001293797.2 → NP_001280726.1  transmembrane protein 161A isoform 2

    See identical proteins and their annotated locations for NP_001280726.1

    Status: VALIDATED

    Source sequence(s)
    AC124327
    Consensus CDS
    CCDS80890.1
    UniProtKB/Swiss-Prot
    Q8VCA6
    Related
    ENSMUSP00000138499.2, ENSMUST00000182980.8
    Conserved Domains (1) summary
    pfam10268
    Location:2 → 325
    Tmemb_161AB; Predicted transmembrane protein 161AB

  2. NM_001426658.1 → NP_001413587.1  transmembrane protein 161A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC124327

  3. NM_001426659.1 → NP_001413588.1  transmembrane protein 161A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC124327

  4. NM_001426660.1 → NP_001413589.1  transmembrane protein 161A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC124327

  5. NM_001426661.1 → NP_001413590.1  transmembrane protein 161A isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC124327

  6. NM_145597.5 → NP_663572.1  transmembrane protein 161A isoform 1 precursor

    See identical proteins and their annotated locations for NP_663572.1

    Status: VALIDATED

    Source sequence(s)
    AC124327
    Consensus CDS
    CCDS40369.1
    UniProtKB/Swiss-Prot
    Q8BNL7, Q8BSL1, Q8C2I8, Q8VCA6
    UniProtKB/TrEMBL
    F6UNW2
    Related
    ENSMUSP00000002413.9, ENSMUST00000002413.15
    Conserved Domains (1) summary
    pfam10268
    Location:2 → 477
    Tmemb_161AB; Predicted transmembrane protein 161AB

RNA

  1. NR_122028.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC124327

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    70624979..70636331
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242296.2 → XP_011240598.1  transmembrane protein 161A isoform X4

    Conserved Domains (1) summary
    pfam10268
    Location:33 → 311
    Tmemb_161AB; Predicted transmembrane protein 161AB
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VCA6.1 GenPept UniProtKB/Swiss-Prot:Q8VCA6

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