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Zfp612 zinc finger protein 612 [ Mus musculus (house mouse) ]

Gene ID: 234725, updated on 2-Nov-2024

Summary

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Official Symbol
Zfp612provided by MGI
Official Full Name
zinc finger protein 612provided by MGI
Primary source
MGI:MGI:2443465
See related
Ensembl:ENSMUSG00000044676 AllianceGenome:MGI:2443465
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B230354B21Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in central nervous system; early conceptus; reproductive system; and urinary system. Orthologous to human ZNF23 (zinc finger protein 23). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in cerebellum adult (RPKM 8.9), cortex adult (RPKM 5.8) and 18 other tissues See more
Orthologs
human all
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Genomic context

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See Zfp612 in Genome Data Viewer
Location:
8 D3; 8 57.41 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (110806331..110819385)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (110079705..110092753)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene carbohydrate sulfotransferase 4 Neighboring gene RIKEN cDNA 8030455M16 gene Neighboring gene TLE family member 7 Neighboring gene predicted gene, 35543

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2. Takeda K, et al. Mol Cell Biol, 2006 Nov. PMID 16966370, Free PMC Article
  2. Identification of candidate maternal-effect genes through comparison of multiple microarray data sets. Mager J, et al. Mamm Genome, 2006 Sep. PMID 16964442
  3. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article
  4. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175480.4 → NP_780689.3  zinc finger protein 23

    See identical proteins and their annotated locations for NP_780689.3

    Status: VALIDATED

    Source sequence(s)
    AC124409, AI603944, AK046220, AK162867, BY123080
    Consensus CDS
    CCDS22660.1
    UniProtKB/TrEMBL
    A0A1D5RMC2
    Related
    ENSMUSP00000148717.2, ENSMUST00000212754.2
    Conserved Domains (3) summary
    smart00349
    Location:11 → 71
    KRAB; krueppel associated box
    COG5048
    Location:251 → 657
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:451 → 471
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    110806331..110819385
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530908.2 → XP_006530971.1  zinc finger protein 23 isoform X1

    See identical proteins and their annotated locations for XP_006530971.1

    Conserved Domains (3) summary
    smart00349
    Location:74 → 134
    KRAB; krueppel associated box
    COG5048
    Location:314 → 720
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:514 → 534
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_006530910.4 → XP_006530973.1  zinc finger protein 23 isoform X3

    See identical proteins and their annotated locations for XP_006530973.1

    Conserved Domains (3) summary
    smart00349
    Location:22 → 82
    KRAB; krueppel associated box
    COG5048
    Location:262 → 668
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:462 → 482
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. XM_006530912.4 → XP_006530975.1  zinc finger protein 23 isoform X4

    See identical proteins and their annotated locations for XP_006530975.1

    UniProtKB/TrEMBL
    A0A1D5RMC2
    Conserved Domains (3) summary
    smart00349
    Location:11 → 71
    KRAB; krueppel associated box
    COG5048
    Location:251 → 657
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:451 → 471
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. XM_030243508.1 → XP_030099368.1  zinc finger protein 23 isoform X5

    Conserved Domains (3) summary
    COG5048
    Location:215 → 621
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:415 → 435
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:10 → 50
    KRAB; KRAB box

  5. XM_006530907.4 → XP_006530970.1  zinc finger protein 23 isoform X1

    See identical proteins and their annotated locations for XP_006530970.1

    Conserved Domains (3) summary
    smart00349
    Location:74 → 134
    KRAB; krueppel associated box
    COG5048
    Location:314 → 720
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:514 → 534
    ZF_C2H2; C2H2 Zn finger [structural motif]

  6. XM_011248359.3 → XP_011246661.1  zinc finger protein 23 isoform X2

    Conserved Domains (3) summary
    COG5048
    Location:278 → 684
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:478 → 498
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:73 → 113
    KRAB; KRAB box

  7. XM_006530909.4 → XP_006530972.1  zinc finger protein 23 isoform X3

    See identical proteins and their annotated locations for XP_006530972.1

    Conserved Domains (3) summary
    smart00349
    Location:22 → 82
    KRAB; krueppel associated box
    COG5048
    Location:262 → 668
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:462 → 482
    ZF_C2H2; C2H2 Zn finger [structural motif]

  8. XM_030243509.1 → XP_030099369.1  zinc finger protein 23 isoform X6

    UniProtKB/TrEMBL
    G5E8C8, Q3V041
    Conserved Domains (3) summary
    COG5048
    Location:212 → 618
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:412 → 432
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:1 → 32
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

  9. XM_006530915.4 → XP_006530978.1  zinc finger protein 23 isoform X6

    See identical proteins and their annotated locations for XP_006530978.1

    UniProtKB/TrEMBL
    G5E8C8, Q3V041
    Related
    ENSMUSP00000062474.10, ENSMUST00000058804.10
    Conserved Domains (3) summary
    COG5048
    Location:212 → 618
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:412 → 432
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:1 → 32
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

  10. XM_030243507.1 → XP_030099367.1  zinc finger protein 23 isoform X5

    Conserved Domains (3) summary
    COG5048
    Location:215 → 621
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:415 → 435
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:10 → 50
    KRAB; KRAB box

  11. XM_011248360.2 → XP_011246662.1  zinc finger protein 23 isoform X6

    See identical proteins and their annotated locations for XP_011246662.1

    UniProtKB/TrEMBL
    G5E8C8, Q3V041
    Conserved Domains (3) summary
    COG5048
    Location:212 → 618
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:412 → 432
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:1 → 32
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
Nucleotide Protein Strain
Heading Accession and Version

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