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SEC61G SEC61 translocon subunit gamma [ Homo sapiens (human) ]

Gene ID: 23480, updated on 5-Mar-2024

Summary

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Official Symbol
SEC61Gprovided by HGNC
Official Full Name
SEC61 translocon subunit gammaprovided by HGNC
Primary source
HGNC:HGNC:18277
See related
Ensembl:ENSG00000132432 MIM:609215; AllianceGenome:HGNC:18277
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SSS1
Summary
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the gamma-subunit protein. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in colon (RPKM 71.5), prostate (RPKM 56.4) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
7p11.2
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (54752253..54759211, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (54912179..54919137, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (54819946..54826904, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 1125, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:54731509-54732224 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:54732225-54732940 Neighboring gene ribosomal protein L31 pseudogene 35 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr7:54742531-54743176 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr7:54743177-54743822 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:54748033-54748601 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18184 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:54827107-54828042 Neighboring gene SEC61G divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18185 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:54847531-54848394 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:54848395-54849258 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:54849259-54850122 Neighboring gene negCOR silencer S2 Neighboring gene uncharacterized LOC124901636

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. SEC61G Promotes Cervical Cancer Proliferation by Activating MAPK Signaling Pathway. Fan Y, et al. Dis Markers, 2022. PMID 36092956, Free PMC Article
  2. Prognostic value of SEC61G in lung adenocarcinoma: a comprehensive study based on bioinformatics and in vitro validation. Zheng Q, et al. BMC Cancer, 2021 Nov 13. PMID 34774014, Free PMC Article
  3. SEC61G overexpression and DNA amplification correlates with prognosis and immune cell infiltration in head and neck squamous cell carcinoma. Lu T, et al. Cancer Med, 2021 Nov. PMID 34590792, Free PMC Article
  4. SEC61G identified as a prognostic biomarker of head and neck squamous cell carcinoma. Shi Y, et al. Eur Arch Otorhinolaryngol, 2022 Apr. PMID 34173014, Free PMC Article
  5. SEC61G promotes breast cancer development and metastasis via modulating glycolysis and is transcriptionally regulated by E2F1. Ma J, et al. Cell Death Dis, 2021 May 27. PMID 34039955, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SEC61G Promotes Cervical Cancer Proliferation by Activating MAPK Signaling Pathway.
    Title: SEC61G Promotes Cervical Cancer Proliferation by Activating MAPK Signaling Pathway.
  2. SEC61G identified as a prognostic biomarker of head and neck squamous cell carcinoma.
    Title: SEC61G identified as a prognostic biomarker of head and neck squamous cell carcinoma.
  3. SEC61G overexpression and DNA amplification correlates with prognosis and immune cell infiltration in head and neck squamous cell carcinoma.
    Title: SEC61G overexpression and DNA amplification correlates with prognosis and immune cell infiltration in head and neck squamous cell carcinoma.
  4. Prognostic value of SEC61G in lung adenocarcinoma: a comprehensive study based on bioinformatics and in vitro validation.
    Title: Prognostic value of SEC61G in lung adenocarcinoma: a comprehensive study based on bioinformatics and in vitro validation.
  5. SEC61G plays an oncogenic role in hepatocellular carcinoma cells.
    Title: SEC61G plays an oncogenic role in hepatocellular carcinoma cells.
  6. SEC61G is upregulated and required for tumor progression in human kidney cancer.
    Title: SEC61G is upregulated and required for tumor progression in human kidney cancer.
  7. SEC61G promotes breast cancer development and metastasis via modulating glycolysis and is transcriptionally regulated by E2F1.
    Title: SEC61G promotes breast cancer development and metastasis via modulating glycolysis and is transcriptionally regulated by E2F1.
  8. LncRNA LINC02418 regulates proliferation and apoptosis of non-small cell lung cancer cells by regulating miR-4677-3p/SEC61G.
    Title: LncRNA LINC02418 regulates proliferation and apoptosis of non-small cell lung cancer cells by regulating miR-4677-3p/SEC61G.
  9. High expression of SEC61G was significantly correlated with poor prognosis in all GBM patients. High expression of SEC61G was also associated with poor outcome.
    Title: Identification of SEC61G as a Novel Prognostic Marker for Predicting Survival and Response to Therapies in Patients with Glioblastoma.
  10. Sequencing of childhood ependymoma samples indicate Sec61 gamma subunit protein (SEC61G)-epidermal growth factor receptor (EGFR) chimeric mRNAs in one infratentorial ependymoma , arguing that this fusion occurs in a small proportion of these tumors.
    Title: Novel SEC61G-EGFR Fusion Gene in Pediatric Ependymomas Discovered by Clonal Expansion of Stem Cells in Absence of Exogenous Mitogens.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic Loci Associated with Circulating Levels of Very Long-Chain Saturated Fatty Acids.
EBI GWAS Catalog
GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of Sec61 gamma subunit (SEC61G) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ribosome binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in post-translational protein targeting to membrane, translocation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein targeting to ER ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of Ssh1 translocon complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protein transport protein Sec61 subunit gamma
Names
SEC61 translocon gamma subunit
Sec61 gamma subunit
protein transport protein SEC61 gamma subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012456.2 → NP_001012474.1  protein transport protein Sec61 subunit gamma

    See identical proteins and their annotated locations for NP_001012474.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AF086539, BU932672, CD385140
    Consensus CDS
    CCDS5513.1
    UniProtKB/Swiss-Prot
    B2R4J0, P38384, P60059, Q6IB25
    Related
    ENSP00000378906.3, ENST00000395535.7
    Conserved Domains (1) summary
    cl00481
    Location:12 → 68
    SecE; SecE/Sec61-gamma subunits of protein translocation complex

  2. NM_014302.4 → NP_055117.1  protein transport protein Sec61 subunit gamma

    See identical proteins and their annotated locations for NP_055117.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AF086539, BU932672, CD385140
    Consensus CDS
    CCDS5513.1
    UniProtKB/Swiss-Prot
    B2R4J0, P38384, P60059, Q6IB25
    Related
    ENSP00000341538.4, ENST00000352861.9
    Conserved Domains (1) summary
    cl00481
    Location:12 → 68
    SecE; SecE/Sec61-gamma subunits of protein translocation complex

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    54752253..54759211 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    54912179..54919137 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P60059.1 GenPept UniProtKB/Swiss-Prot:P60059

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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