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Piezo1 piezo-type mechanosensitive ion channel component 1 [ Mus musculus (house mouse) ]

Gene ID: 234839, updated on 12-Nov-2024

Summary

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Official Symbol
Piezo1provided by MGI
Official Full Name
piezo-type mechanosensitive ion channel component 1provided by MGI
Primary source
MGI:MGI:3603204
See related
Ensembl:ENSMUSG00000014444 AllianceGenome:MGI:3603204
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fam38a; mKIAA0233; 9630020g22
Summary
Enables identical protein binding activity and mechanosensitive monoatomic cation channel activity. Involved in monoatomic cation transport and positive regulation of myotube differentiation. Acts upstream of or within detection of mechanical stimulus and regulation of membrane potential. Located in cuticular plate; plasma membrane; and stereocilium. Is expressed in several structures, including brain; hemolymphoid system; liver; lung; and skin. Human ortholog(s) of this gene implicated in dehydrated hereditary stomatocytosis 1 and hereditary lymphedema. Orthologous to human PIEZO1 (piezo type mechanosensitive ion channel component 1 (Er blood group)). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in lung adult (RPKM 39.8), ovary adult (RPKM 31.9) and 23 other tissues See more
Orthologs
human all
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Genomic context

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See Piezo1 in Genome Data Viewer
Location:
8 E1; 8 71.31 cM
Exon count:
53
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (123208437..123278068, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (122481698..122551329, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene snail family zinc finger 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:124993848-124994115 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:124994651-124994852 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:124997832-124998091 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:124999099-124999282 Neighboring gene ring finger protein 166 Neighboring gene cytosolic thiouridylase subunit 2 Neighboring gene STARR-seq mESC enhancer starr_22950 Neighboring gene predicted gene, 26497 Neighboring gene STARR-positive B cell enhancer ABC_E1108 Neighboring gene STARR-positive B cell enhancer ABC_E6699 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:125080544-125080815 Neighboring gene predicted gene, 34847 Neighboring gene STARR-positive B cell enhancer ABC_E8270 Neighboring gene chromatin licensing and DNA replication factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Piezo1-Regulated Mechanotransduction Controls Flow-Activated Lymphatic Expansion. Choi D, et al. Circ Res, 2022 Jul 8. PMID 35701867, Free PMC Article
  2. Astrocytic Piezo1-mediated mechanotransduction determines adult neurogenesis and cognitive functions. Chi S, et al. Neuron, 2022 Sep 21. PMID 35963237
  3. RBCs prevent rapid PIEZO1 inactivation and expose slow deactivation as a mechanism of dehydrated hereditary stomatocytosis. Evans EL, et al. Blood, 2020 Jul 2. PMID 32305040, Free PMC Article
  4. Piezo1 Channel as a Potential Target for Hindering Cardiac Fibrotic Remodeling. Braidotti N, et al. Int J Mol Sci, 2022 Jul 22. PMID 35897650, Free PMC Article
  5. Mechanical-induced bone remodeling does not depend on Piezo1 in dentoalveolar hard tissue. Nottmeier C, et al. Sci Rep, 2023 Jun 12. PMID 37308580, Free PMC Article

See all (229) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Acute contact with profibrotic macrophages mechanically activates fibroblasts via alphavbeta3 integrin-mediated engagement of Piezo1.
    Title: Acute contact with profibrotic macrophages mechanically activates fibroblasts via αvβ3 integrin-mediated engagement of Piezo1.
  2. Mechanosensing by Piezo1 in gastric ghrelin cells contributes to hepatic lipid homeostasis in mice.
    Title: Mechanosensing by Piezo1 in gastric ghrelin cells contributes to hepatic lipid homeostasis in mice.
  3. Piezo1 mediates mechanical signals in TRPV1-positive nociceptors in mice.
    Title: Piezo1 mediates mechanical signals in TRPV1-positive nociceptors in mice.
  4. Piezo1 activation on microglial cells exacerbates demyelination in sepsis by influencing the CCL25/GRP78 pathway.
    Title: Piezo1 activation on microglial cells exacerbates demyelination in sepsis by influencing the CCL25/GRP78 pathway.
  5. Functional coupling between Piezo1 and TRPM4 influences the electrical activity of HL-1 atrial myocytes.
    Title: Functional coupling between Piezo1 and TRPM4 influences the electrical activity of HL-1 atrial myocytes.
  6. Piezo1 ion channels are capable of conformational signaling.
    Title: Piezo1 ion channels are capable of conformational signaling.
  7. Piezo1 stretch-activated channel activity differs between murine bone marrow-derived and cardiac tissue-resident macrophages.
    Title: Piezo1 stretch-activated channel activity differs between murine bone marrow-derived and cardiac tissue-resident macrophages.
  8. Piezo1 mediates the degradation of cartilage extracellular matrix in malocclusion-induced TMJOA.
    Title: Piezo1 mediates the degradation of cartilage extracellular matrix in malocclusion-induced TMJOA.
  9. PIEZO1 targeting in macrophages boosts phagocytic activity and foam cell apoptosis in atherosclerosis.
    Title: PIEZO1 targeting in macrophages boosts phagocytic activity and foam cell apoptosis in atherosclerosis.
  10. Occlusal force orchestrates alveolar bone homeostasis via Piezo1 in female mice.
    Title: Occlusal force orchestrates alveolar bone homeostasis via Piezo1 in female mice.
Submit: New GeneRIF Correction See all GeneRIFs (173)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables mechanosensitive monoatomic cation channel activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables mechanosensitive monoatomic cation channel activity ISO
Inferred from Sequence Orthology
more info
  
enables mechanosensitive monoatomic ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mechanosensitive monoatomic ion channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables mechanosensitive monoatomic ion channel activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables monoatomic cation channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables monoatomic cation channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables monoatomic cation channel activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to mechanical stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in detection of mechanical stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within detection of mechanical stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in monoatomic cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic cation transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in monoatomic cation transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell-cell adhesion mediated by integrin ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell-cell adhesion mediated by integrin ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of integrin activation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of integrin activation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of myotube differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of myotube differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of membrane potential IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cuticular plate IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment membrane IEA
Inferred from Electronic Annotation
more info
  
located_in lamellipodium membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in stereocilium IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
piezo-type mechanosensitive ion channel component 1
Names
family with sequence similarity 38, member A
protein PIEZO1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037298.1 → NP_001032375.1  piezo-type mechanosensitive ion channel component 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC114917
    Consensus CDS
    CCDS52695.1
    UniProtKB/Swiss-Prot
    E2JF22
    UniProtKB/TrEMBL
    E9PUQ9
    Related
    ENSMUSP00000089777.6, ENSMUST00000067252.14
    Conserved Domains (2) summary
    pfam12166
    Location:2126 → 2544
    Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
    pfam15917
    Location:1229 → 1452
    PIEZO; Piezo

  2. NM_001357349.1 → NP_001344278.1  piezo-type mechanosensitive ion channel component 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC114917
    Consensus CDS
    CCDS90474.1
    UniProtKB/Swiss-Prot
    E2JF22
    UniProtKB/TrEMBL
    F7AC58
    Related
    ENSMUSP00000114584.3, ENSMUST00000156333.9
    Conserved Domains (2) summary
    pfam12166
    Location:2127 → 2545
    Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
    pfam15917
    Location:1230 → 1453
    PIEZO; Piezo

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    123208437..123278068 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530954.2 → XP_006531017.2  piezo-type mechanosensitive ion channel component 1 isoform X2

    UniProtKB/Swiss-Prot
    E2JF22
    Conserved Domains (2) summary
    pfam12166
    Location:2121 → 2539
    Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
    pfam15917
    Location:1224 → 1447
    PIEZO; Piezo

  2. XM_006530956.2 → XP_006531019.2  piezo-type mechanosensitive ion channel component 1 isoform X3

    UniProtKB/Swiss-Prot
    E2JF22
    Conserved Domains (2) summary
    pfam12166
    Location:2098 → 2516
    Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
    pfam15917
    Location:1225 → 1424
    PIEZO; Piezo

  3. XM_006530953.2 → XP_006531016.2  piezo-type mechanosensitive ion channel component 1 isoform X1

    UniProtKB/Swiss-Prot
    E2JF22
    Conserved Domains (2) summary
    pfam12166
    Location:2122 → 2540
    Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
    pfam15917
    Location:1225 → 1448
    PIEZO; Piezo

  4. XM_006530959.3 → XP_006531022.1  piezo-type mechanosensitive ion channel component 1 isoform X5

    UniProtKB/TrEMBL
    Q80XT7
    Conserved Domains (2) summary
    pfam12166
    Location:1397 → 1815
    Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
    pfam15917
    Location:500 → 723
    PIEZO; Piezo

  5. XM_011248372.2 → XP_011246674.1  piezo-type mechanosensitive ion channel component 1 isoform X6

    UniProtKB/TrEMBL
    Q6ZQF9
    Conserved Domains (2) summary
    pfam12166
    Location:976 → 1394
    Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
    pfam15917
    Location:79 → 302
    PIEZO; Piezo

  6. XM_006530957.3 → XP_006531020.2  piezo-type mechanosensitive ion channel component 1 isoform X4

    UniProtKB/Swiss-Prot
    E2JF22
    Conserved Domains (2) summary
    pfam12166
    Location:2122 → 2173
    Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
    pfam15917
    Location:1225 → 1448
    PIEZO; Piezo
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E2JF22.1 GenPept UniProtKB/Swiss-Prot:E2JF22

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