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CBX7 chromobox 7 [ Homo sapiens (human) ]

Gene ID: 23492, updated on 2-Nov-2024

Summary

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Official Symbol
CBX7provided by HGNC
Official Full Name
chromobox 7provided by HGNC
Primary source
HGNC:HGNC:1557
See related
Ensembl:ENSG00000100307 MIM:608457; AllianceGenome:HGNC:1557
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a protein that contains the CHROMO (CHRomatin Organization MOdifier) domain. The encoded protein is a component of the Polycomb repressive complex 1 (PRC1), and is thought to control the lifespan of several normal human cells. [provided by RefSeq, Oct 2016]
Expression
Ubiquitous expression in ovary (RPKM 27.3), endometrium (RPKM 25.8) and 25 other tissues See more
Orthologs
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Genomic context

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See CBX7 in Genome Data Viewer
Location:
22q13.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (39130772..39152680, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (39601155..39623071, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (39526777..39548685, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr22:39492371-39493570 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:39493781-39494667 Neighboring gene apolipoprotein B mRNA editing enzyme catalytic subunit 3H Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:39509973-39510947 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19031 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19032 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13742 Neighboring gene cytochrome c oxidase subunit 5B pseudogene 7 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:39527431-39527992 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:39529632-39530316 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:39530317-39531000 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:39531107-39532084 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:39540727-39541516 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13744 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:39544030-39544628 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:39544629-39545227 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:39548263-39548844 Neighboring gene FUN14 domain containing 2 pseudogene 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:39567703-39568508 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:39569521-39570190 Neighboring gene Sharpr-MPRA regulatory region 8665 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:39601000-39601939 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:39605384-39605884 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:39609067-39609686 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:39609687-39610305 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr22:39610322-39611521 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:39612165-39612782 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:39632330-39633224 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:39633225-39634119 Neighboring gene platelet derived growth factor subunit B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19036 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13747

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Chromodomain antagonists that target the polycomb-group methyllysine reader protein chromobox homolog 7 (CBX7). Simhadri C, et al. J Med Chem, 2014 Apr 10. PMID 24625057
  2. CBX7 negatively regulates migration and invasion in glioma via Wnt/β-catenin pathway inactivation. Bao Z, et al. Oncotarget, 2017 Jun 13. PMID 28388562, Free PMC Article
  3. Potential role of CBX7 in regulating pluripotency of adult human pluripotent-like olfactory stem cells in stroke model. Fan JR, et al. Cell Death Dis, 2018 May 1. PMID 29717132, Free PMC Article
  4. Restoration of CBX7 expression increases the susceptibility of human lung carcinoma cells to irinotecan treatment. Cacciola NA, et al. Naunyn Schmiedebergs Arch Pharmacol, 2015 Nov. PMID 26216446
  5. Critical evaluation of Cbx7 downregulation in primary colon carcinomas and its clinical significance in Chinese patients. Zheng X, et al. BMC Cancer, 2015 Mar 18. PMID 25881303, Free PMC Article

See all (76) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CBX7 promotes choroidal neovascularization by activating the HIF-1alpha/VEGF pathway in choroidal vascular endothelial cells.
    Title: CBX7 promotes choroidal neovascularization by activating the HIF-1α/VEGF pathway in choroidal vascular endothelial cells.
  2. A novel nanoplatform-based circCSNK1G3 affects CBX7 protein and promotes glioma cell growth.
    Title: A novel nanoplatform-based circCSNK1G3 affects CBX7 protein and promotes glioma cell growth.
  3. CBX7 reprograms metabolic flux to protect against meningioma progression by modulating the USP44/c-MYC/LDHA axis.
    Title: CBX7 reprograms metabolic flux to protect against meningioma progression by modulating the USP44/c-MYC/LDHA axis.
  4. Subcellular expression pattern and clinical significance of CBX2 and CBX7 in breast cancer subtypes.
    Title: Subcellular expression pattern and clinical significance of CBX2 and CBX7 in breast cancer subtypes.
  5. Adipose-derived exosomal miR-421 targets CBX7 and promotes metastatic potential in ovarian cancer cells.
    Title: Adipose-derived exosomal miR-421 targets CBX7 and promotes metastatic potential in ovarian cancer cells.
  6. Expression and correlation analysis of Skp2 and CBX7 in cervical cancer.
    Title: Expression and correlation analysis of Skp2 and CBX7 in cervical cancer.
  7. CBX7 represses the POU2F2 to inhibit the PD-L1 expression and regulate the immune response in bladder cancer.
    Title: CBX7 represses the POU2F2 to inhibit the PD-L1 expression and regulate the immune response in bladder cancer.
  8. Multiomics integrative analysis reveals antagonistic roles of CBX2 and CBX7 in metabolic reprogramming of breast cancer.
    Title: Multiomics integrative analysis reveals antagonistic roles of CBX2 and CBX7 in metabolic reprogramming of breast cancer.
  9. CBX7 suppresses urinary bladder cancer progression via modulating AKR1B10-ERK signaling.
    Title: CBX7 suppresses urinary bladder cancer progression via modulating AKR1B10-ERK signaling.
  10. MicroRNA-18a suppresses ovarian carcinoma progression by targeting CBX7 and regulating ERK/MAPK signaling pathway and epithelial-to-mesenchymal transition.
    Title: MicroRNA-18a suppresses ovarian carcinoma progression by targeting CBX7 and regulating ERK/MAPK signaling pathway and epithelial-to-mesenchymal transition.
Submit: New GeneRIF Correction See all GeneRIFs (44)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk.
EBI GWAS Catalog
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of PRC1 complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of PcG protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of PcG protein complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
chromobox protein homolog 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051974.1 RefSeqGene

    Range
    4971..26879
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001346743.2 → NP_001333672.1  chromobox protein homolog 7 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AL031846, BU584870
    Conserved Domains (2) summary
    cd18646
    Location:7 → 62
    CD_Cbx7; chromodomain of chromobox homolog 7
    pfam17218
    Location:208 → 239
    CBX7_C; CBX family C-terminal motif

  2. NM_001346744.2 → NP_001333673.1  chromobox protein homolog 7 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AL031846, BU584870, BU584877, DQ064603
    Consensus CDS
    CCDS87028.1
    UniProtKB/TrEMBL
    B0QYP2, Q4PNR6
    Related
    ENSP00000384035.3, ENST00000401405.7
    Conserved Domains (2) summary
    cd18646
    Location:7 → 62
    CD_Cbx7; chromodomain of chromobox homolog 7
    pfam17218
    Location:116 → 147
    CBX7_C; CBX family C-terminal motif

  3. NM_175709.5 → NP_783640.1  chromobox protein homolog 7 isoform 1

    See identical proteins and their annotated locations for NP_783640.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL031846, BC051773, BU584870, BU584877
    Consensus CDS
    CCDS13986.1
    UniProtKB/Swiss-Prot
    O95931, Q86T17
    Related
    ENSP00000216133.5, ENST00000216133.10
    Conserved Domains (2) summary
    cd18646
    Location:7 → 62
    CD_Cbx7; chromodomain of chromobox homolog 7
    pfam17218
    Location:209 → 240
    CBX7_C; CBX family C-terminal motif

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    39130772..39152680 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    39601155..39623071 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O95931.1 GenPept UniProtKB/Swiss-Prot:O95931

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