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Plppr2 phospholipid phosphatase related 2 [ Mus musculus (house mouse) ]

Gene ID: 235044, updated on 2-Nov-2024

Summary

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Official Symbol
Plppr2provided by MGI
Official Full Name
phospholipid phosphatase related 2provided by MGI
Primary source
MGI:MGI:2384575
See related
Ensembl:ENSMUSG00000040563 AllianceGenome:MGI:2384575
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lppr2; PRG-4
Summary
Predicted to enable phosphatidate phosphatase activity. Predicted to be involved in phospholipid dephosphorylation; phospholipid metabolic process; and signal transduction. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including central nervous system; dorsal root ganglion; forelimb bud; neural retina; and notochord. Orthologous to human PLPPR2 (phospholipid phosphatase related 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E18 (RPKM 47.3), whole brain E14.5 (RPKM 44.3) and 20 other tissues See more
Orthologs
human all
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Genomic context

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See Plppr2 in Genome Data Viewer
Location:
9 A3; 9 7.92 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (21848306..21860203)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (21935684..21948907)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene RAB3D, member RAS oncogene family Neighboring gene transmembrane protein 205 Neighboring gene coiled-coil domain containing 159 Neighboring gene predicted gene, 45914 Neighboring gene SWIM type zinc finger 7 associated protein 1 Neighboring gene erythropoietin receptor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Corticotropin-releasing factor (CRF) receptor type 1-dependent modulation of synaptic plasticity. Schierloh A, et al. Neurosci Lett, 2007 Apr 6. PMID 17316992
  2. Systematic expression analysis of plasticity-related genes in mouse brain development brings PRG4 into play. Gross I, et al. Dev Dyn, 2022 Apr. PMID 34622503
  3. Molecular cloning and expression regulation of PRG-3, a new member of the plasticity-related gene family. Savaskan NE, et al. Eur J Neurosci, 2004 Jan. PMID 14750979
  4. Conditional Deletion of Indian Hedgehog in Limb Mesenchyme Results in Complete Loss of Growth Plate Formation but Allows Mature Osteoblast Differentiation. Amano K, et al. J Bone Miner Res, 2015 Dec. PMID 26094741
  5. Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Lewandowski JP, et al. Dev Biol, 2015 Oct 1. PMID 26238476, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC25492

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phosphatidate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidate phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in phospholipid dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
phospholipid phosphatase-related protein type 2
Names
inactive phospholipid phosphatase PLPPR2
lipid phosphate phosphatase-related protein type 2
plasticity-related gene 4 protein
NP_001277228.1
NP_001397525.1
NP_001397526.1
NP_001397527.1
NP_659184.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290299.1 → NP_001277228.1  phospholipid phosphatase-related protein type 2 isoform 2

    See identical proteins and their annotated locations for NP_001277228.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the central coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a longer and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK082453, AY438023, CX122376
    Consensus CDS
    CCDS72203.1
    UniProtKB/Swiss-Prot
    Q8VCY8
    Related
    ENSMUSP00000038616.7, ENSMUST00000046371.13
    Conserved Domains (1) summary
    cd03384
    Location:125 → 281
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

  2. NM_001410596.1 → NP_001397525.1  phospholipid phosphatase-related protein type 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC166992
    UniProtKB/TrEMBL
    A0A087WQF0
    Related
    ENSMUSP00000140166.2, ENSMUST00000188468.2

  3. NM_001410597.1 → NP_001397526.1  phospholipid phosphatase-related protein type 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC166992
    UniProtKB/Swiss-Prot
    Q8BIE4, Q8VCY8

  4. NM_001410598.1 → NP_001397527.1  phospholipid phosphatase-related protein type 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC166992

  5. NM_144935.1 → NP_659184.1  phospholipid phosphatase-related protein type 2 isoform 1

    See identical proteins and their annotated locations for NP_659184.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (1).
    Source sequence(s)
    BC018242
    Consensus CDS
    CCDS80966.1
    UniProtKB/Swiss-Prot
    Q8BIE4, Q8VCY8
    Related
    ENSMUSP00000139727.2, ENSMUST00000190387.7
    Conserved Domains (1) summary
    cd03384
    Location:125 → 281
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    21848306..21860203
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VCY8.1 GenPept UniProtKB/Swiss-Prot:Q8VCY8

Gene LinkOut

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