Ttc12 tetratricopeptide repeat domain 12 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ttc12provided by MGI
Official Full Name: tetratricopeptide repeat domain 12provided by MGI
Primary source: MGI:MGI:2444588
See related: Ensembl:ENSMUSG00000040219 AllianceGenome:MGI:2444588
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: E330017O07Rik
Summary: Predicted to be involved in axonemal dynein complex assembly and sperm axoneme assembly. Predicted to be active in centrosome and cytoplasm. Is expressed in brain ventricle and brain ventricular layer. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; alcohol dependence; drug dependence (multiple); nicotine dependence; and primary ciliary dyskinesia 45. Orthologous to human TTC12 (tetratricopeptide repeat domain 12). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in testis adult (RPKM 10.4), heart adult (RPKM 3.7) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A5.3; 9 26.83 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (49348261..49397572, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (49436961..49486275, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in axonemal dynein complex assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in axonemal dynein complex assembly	ISO Inferred from Sequence Orthology more info
involved_in axonemal dynein complex assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in sperm axoneme assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in sperm axoneme assembly	ISO Inferred from Sequence Orthology more info
involved_in sperm axoneme assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: tetratricopeptide repeat protein 12

Names: TPR repeat protein 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172770.3 → NP_766358.1 tetratricopeptide repeat protein 12

See identical proteins and their annotated locations for NP_766358.1

Status: PROVISIONAL

Source sequence(s)

AC117630, AC167980

Consensus CDS

CCDS23163.1

UniProtKB/Swiss-Prot

Q8BW49

Related

ENSMUSP00000056378.5, ENSMUST00000055096.5

Conserved Domains (2) summary

PLN03088
Location:104 → 254

PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional

sd00006
Location:105 → 133

TPR; TPR repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

49348261..49397572 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030244325.2 → XP_030100185.1 tetratricopeptide repeat protein 12 isoform X2

Conserved Domains (2) summary

PLN03088
Location:79 → 248

PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional

sd00006
Location:80 → 108

TPR; TPR repeat [structural motif]
XM_011242510.3 → XP_011240812.1 tetratricopeptide repeat protein 12 isoform X1

Conserved Domains (2) summary

TIGR00990
Location:34 → 175

3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)

sd00006
Location:105 → 133

TPR; TPR repeat [structural motif]
XM_011242511.1 → XP_011240813.1 tetratricopeptide repeat protein 12 isoform X3

Conserved Domains (2) summary

PLN03088
Location:104 → 273

PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional

sd00006
Location:105 → 133

TPR; TPR repeat [structural motif]