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Hoatz HOATZ cilia and flagella associated protein [ Mus musculus (house mouse) ]

Gene ID: 235345, updated on 28-Oct-2024

Summary

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Official Symbol
Hoatzprovided by MGI
Official Full Name
HOATZ cilia and flagella associated proteinprovided by MGI
Primary source
MGI:MGI:1921013
See related
Ensembl:ENSMUSG00000032057 AllianceGenome:MGI:1921013
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hoatzin; 4833427G06Rik
Summary
Involved in axoneme assembly; flagellated sperm motility; and spermatogenesis. Located in cilium and cytoplasm. Is expressed in embryo and lung. Orthologous to human HOATZ (HOATZ cilia and flagella associated protein). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in testis adult (RPKM 20.5) and lung adult (RPKM 1.2) See more
Orthologs
human all
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Genomic context

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See Hoatz in Genome Data Viewer
Location:
9 A5.3; 9 27.81 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (50992610..51017183, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (51081310..51105834, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 2, regulatory subunit A, beta Neighboring gene salt inducible kinase 2 Neighboring gene STARR-seq mESC enhancer starr_24123 Neighboring gene STARR-seq mESC enhancer starr_24124 Neighboring gene STARR-positive B cell enhancer ABC_E8290 Neighboring gene predicted gene, 32681 Neighboring gene layilin Neighboring gene STARR-seq mESC enhancer starr_24125 Neighboring gene microRNA 34b Neighboring gene microRNA 34c Neighboring gene BTG anti-proliferation factor 4 Neighboring gene predicted gene, 32742 Neighboring gene STARR-positive B cell enhancer ABC_E10544 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:50973591-50973879 Neighboring gene STARR-seq mESC enhancer starr_24126 Neighboring gene STARR-positive B cell enhancer ABC_E6731 Neighboring gene STARR-positive B cell enhancer ABC_E10545 Neighboring gene STARR-positive B cell enhancer ABC_E6732 Neighboring gene POU domain, class 2, associating factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Carboxyl Terminus of HOATZ is Intrinsically Disordered and Interacts with Heat Shock Protein A Families. Narita K, et al. Protein Pept Lett, 2022. PMID 36098411
  2. Discovery of a Vertebrate-Specific Factor that Processes Flagellar Glycolytic Enolase during Motile Ciliogenesis. Narita K, et al. iScience, 2020 Apr 24. PMID 32248064, Free PMC Article
  3. Identification of FOXJ1 effectors during ciliogenesis in the foetal respiratory epithelium and embryonic left-right organiser of the mouse. Stauber M, et al. Dev Biol, 2017 Mar 15. PMID 27914912
  4. Tissue expression patterns identify mouse cilia genes. McClintock TS, et al. Physiol Genomics, 2008 Jan 17. PMID 17971504
  5. Integrated microarray and ChIP analysis identifies multiple Foxa2 dependent target genes in the notochord. Tamplin OJ, et al. Dev Biol, 2011 Dec 15. PMID 22008794

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Clone Names

  • MGC58631

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in axoneme assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in flagellated sperm motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cilia- and flagella-associated protein HOATZ
Names
UPF0722 protein C11orf88 homolog
protein Hoatz

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177702.4 → NP_808370.1  cilia- and flagella-associated protein HOATZ

    See identical proteins and their annotated locations for NP_808370.1

    Status: PROVISIONAL

    Source sequence(s)
    AC119831
    Consensus CDS
    CCDS40628.1
    UniProtKB/Swiss-Prot
    Q3V0W8, Q80Y73
    UniProtKB/TrEMBL
    Q9D5Z9
    Related
    ENSMUSP00000126725.2, ENSMUST00000170947.3
    Conserved Domains (1) summary
    pfam17664
    Location:1 → 168
    DUF5526; Family of unknown function (DUF5526)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    50992610..51017183 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244326.2 → XP_030100186.1  cilia- and flagella-associated protein HOATZ isoform X1

    UniProtKB/Swiss-Prot
    Q3V0W8, Q80Y73
    UniProtKB/TrEMBL
    Q9D5Z9
    Conserved Domains (1) summary
    pfam17664
    Location:1 → 168
    DUF5526; Family of unknown function (DUF5526)

  2. XM_030244327.1 → XP_030100187.1  cilia- and flagella-associated protein HOATZ isoform X1

    UniProtKB/Swiss-Prot
    Q3V0W8, Q80Y73
    UniProtKB/TrEMBL
    Q9D5Z9
    Conserved Domains (1) summary
    pfam17664
    Location:1 → 168
    DUF5526; Family of unknown function (DUF5526)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80Y73.1 GenPept UniProtKB/Swiss-Prot:Q80Y73

Gene LinkOut

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