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Gk5 glycerol kinase 5 [ Mus musculus (house mouse) ]

Gene ID: 235533, updated on 2-Nov-2024

Summary

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Official Symbol
Gk5provided by MGI
Official Full Name
glycerol kinase 5provided by MGI
Primary source
MGI:MGI:2443336
See related
Ensembl:ENSMUSG00000041440 AllianceGenome:MGI:2443336
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C330018K18Rik; G630067D24Rik
Summary
Enables glycerol kinase activity. Involved in glycerol-3-phosphate biosynthetic process. Located in cytoplasm. Is expressed in olfactory epithelium and submandibular gland primordium. Orthologous to human GK5 (glycerol kinase 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in genital fat pad adult (RPKM 2.4), limb E14.5 (RPKM 1.9) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Gk5 in Genome Data Viewer
Location:
9 E3.3; 9 50.31 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (96001379..96066680)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (96119344..96184627)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene ataxia telangiectasia and Rad3 related Neighboring gene STARR-positive B cell enhancer ABC_E3852 Neighboring gene predicted gene, 16794 Neighboring gene STARR-positive B cell enhancer ABC_E8307 Neighboring gene STARR-seq mESC enhancer starr_24940 Neighboring gene 5'-3' exoribonuclease 1 Neighboring gene STARR-seq mESC enhancer starr_24941 Neighboring gene STARR-seq mESC enhancer starr_24942 Neighboring gene STARR-positive B cell enhancer ABC_E8308 Neighboring gene STARR-seq mESC enhancer starr_24949 Neighboring gene transcription factor Dp 2 Neighboring gene predicted gene, 39408 Neighboring gene ATPase, Na+/K+ transporting, beta 3 polypeptide

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Skin-specific regulation of SREBP processing and lipid biosynthesis by glycerol kinase 5. Zhang D, et al. Proc Natl Acad Sci U S A, 2017 Jun 27. PMID 28607088, Free PMC Article
  2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  3. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables glycerol kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in glycerol catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycerol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycerol-3-phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycerol-3-phosphate biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in triglyceride metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
glycerol kinase 5; putative glycerol kinase 5
Names
ATP:glycerol 3-phosphotransferase 5
GK 5
glycerokinase 5
glycerol kinase 5 (putative)
NP_001355808.1
NP_796326.1
XP_006511195.1
XP_006511196.1
XP_006511197.1
XP_036010805.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368879.1 → NP_001355808.1  glycerol kinase 5 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC166175
    Consensus CDS
    CCDS90642.1
    UniProtKB/Swiss-Prot
    Q14B67, Q3TK02, Q3TSE0, Q80VA9, Q8BX05
    Related
    ENSMUSP00000082313.6, ENSMUST00000085217.12
    Conserved Domains (1) summary
    cd07793
    Location:25 → 527
    FGGY_GK5_metazoa; metazoan glycerol kinase 5-like proteins; belongs to the FGGY family of carbohydrate kinases

  2. NM_177352.5 → NP_796326.1  glycerol kinase 5 isoform 2

    See identical proteins and their annotated locations for NP_796326.1

    Status: VALIDATED

    Source sequence(s)
    AC166175
    Consensus CDS
    CCDS52891.1
    UniProtKB/Swiss-Prot
    Q8BX05
    Related
    ENSMUSP00000112717.2, ENSMUST00000122383.3
    Conserved Domains (2) summary
    cd07793
    Location:25 → 512
    FGGY_GK5_metazoa; metazoan glycerol kinase 5-like proteins; belongs to the FGGY family of carbohydrate kinases
    COG0554
    Location:20 → 507
    GlpK; Glycerol kinase [Energy production and conversion]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    96001379..96066680
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154912.1 → XP_036010805.1  putative glycerol kinase 5 isoform X4

    Conserved Domains (1) summary
    cl17037
    Location:5 → 388
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  2. XM_006511132.4 → XP_006511195.1  putative glycerol kinase 5 isoform X1

    Conserved Domains (1) summary
    cl17037
    Location:1 → 437
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  3. XM_006511133.3 → XP_006511196.1  putative glycerol kinase 5 isoform X2

    Conserved Domains (1) summary
    cl17037
    Location:13 → 430
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  4. XM_006511134.2 → XP_006511197.1  putative glycerol kinase 5 isoform X3

    Conserved Domains (1) summary
    cl17037
    Location:15 → 424
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

RNA

  1. XR_004935424.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BX05.2 GenPept UniProtKB/Swiss-Prot:Q8BX05

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