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ZNF346 zinc finger protein 346 [ Homo sapiens (human) ]

Gene ID: 23567, updated on 3-Nov-2024

Summary

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Official Symbol
ZNF346provided by HGNC
Official Full Name
zinc finger protein 346provided by HGNC
Primary source
HGNC:HGNC:16403
See related
Ensembl:ENSG00000113761 MIM:605308; AllianceGenome:HGNC:16403
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
JAZ; Zfp346
Summary
The protein encoded by this gene is a nucleolar, zinc finger protein that preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids, rather than DNA alone. Mutational studies indicate that the zinc finger domains are not only essential for dsRNA binding, but are also required for its nucleolar localization. The encoded protein may be involved in cell growth and survival. It plays a role in protecting neurons by inhibiting cell cycle re-entry via stimulation of p21 gene expression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Expression
Ubiquitous expression in ovary (RPKM 2.4), thyroid (RPKM 2.2) and 25 other tissues See more
Orthologs
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Genomic context

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See ZNF346 in Genome Data Viewer
Location:
5q35.2
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (177022696..177081189)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (177565869..177624397)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (176449697..176508190)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene unc-5 netrin receptor A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176314417-176314917 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:176327167-176327668 Neighboring gene hexokinase 3 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:176370315-176371173 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:176371174-176372031 Neighboring gene ubiquitin interaction motif containing 1 Neighboring gene uncharacterized LOC124901145 Neighboring gene MPRA-validated peak5592 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16666 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16667 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16668 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:176449401-176449938 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:176449939-176450475 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16670 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:176488686-176489885 Neighboring gene FGFR4 5' regulatory region Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176537235-176537734 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23693 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176558105-176558658 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr5:176559765-176560316 and GRCh37_chr5:176560317-176560870 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:176560871-176561422 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:176561423-176561976 Neighboring gene fibroblast growth factor receptor 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16676 Neighboring gene nuclear receptor binding SET domain protein 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176692158-176693050 Neighboring gene ribosomal protein L21 pseudogene 60

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Multicenter study identified molecular blood-born protein signatures for Wilms Tumor. Schmitt J, et al. Int J Cancer, 2012 Aug 1. PMID 21913182
  2. Structural characterization of interactions between the double-stranded RNA-binding zinc finger protein JAZ and nucleic acids. Burge RG, et al. Biochemistry, 2014 Mar 11. PMID 24521053, Free PMC Article
  3. ZNF385A and ZNF346 Serve as Prognostic Biomarkers Associated with an Inflamed Immunosuppressive Tumor Microenvironment in Hepatocellular Carcinoma. Peng Q, et al. Int J Mol Sci, 2023 Feb 5. PMID 36834567, Free PMC Article
  4. Human IgG antibody profiles differentiate between symptomatic patients with and without colorectal cancer. Kijanka G, et al. Gut, 2010 Jan. PMID 19828471
  5. JAZ mediates G1 cell cycle arrest by interacting with and inhibiting E2F1. Yang M, et al. Cell Cycle, 2011 Jul 15. PMID 21715977, Free PMC Article

See all (66) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZNF385A and ZNF346 Serve as Prognostic Biomarkers Associated with an Inflamed Immunosuppressive Tumor Microenvironment in Hepatocellular Carcinoma.
    Title: ZNF385A and ZNF346 Serve as Prognostic Biomarkers Associated with an Inflamed Immunosuppressive Tumor Microenvironment in Hepatocellular Carcinoma.
  2. This detection method can be readily extended to multiplex detection of miRNAs with only one ALP-conjugated JAZ probe due to its nonsequence-specific binding character
    Title: Ultrasensitive Electrochemical Detection of miRNA-21 Using a Zinc Finger Protein Specific to DNA-RNA Hybrids.
  3. JAZ directly binds E2F1 in vitro in a dsRNA-independent manner, and JAZ's dsRNA binding ZF domains, which are necessary for localizing JAZ to the nucleus, are required for repression of transcriptional activity in vivo.
    Title: JAZ mediates G1 cell cycle arrest by interacting with and inhibiting E2F1.
  4. JAZ is exported by exportin-5 but translocates back into nuclei by a facilitated diffusion mechanism
    Title: Nucleocytoplasmic shuttling of JAZ, a new cargo protein for exportin-5.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp547M223

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables double-stranded RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables miRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zinc finger protein 346
Names
double-stranded RNA-binding zinc finger protein JAZ
just another zinc finger protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308213.2 → NP_001295142.1  zinc finger protein 346 isoform b

    See identical proteins and their annotated locations for NP_001295142.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an additional in-frame exon in the 5' coding region, and contains an alternate 3' terminal exon and thus differs in the 3' UTR, compared to variant 1. The encoded isoform (b) is longer than isoform a.
    Source sequence(s)
    AK131469, AK297584, CR627467, DA789054, DB340780
    Consensus CDS
    CCDS78094.1
    UniProtKB/Swiss-Prot
    Q9UL40
    UniProtKB/TrEMBL
    B7Z4N4
    Related
    ENSP00000424495.1, ENST00000503039.1
    Conserved Domains (2) summary
    smart00451
    Location:207 → 241
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:161 → 183
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001308214.2 → NP_001295143.1  zinc finger protein 346 isoform c

    See identical proteins and their annotated locations for NP_001295143.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon and uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (c) that is shorter than isoform a.
    Source sequence(s)
    AC027317, AK295549, DA789054, DB548047
    Consensus CDS
    CCDS83052.1
    UniProtKB/Swiss-Prot
    Q9UL40
    Related
    ENSP00000421212.1, ENST00000503425.5
    Conserved Domains (2) summary
    smart00451
    Location:150 → 184
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:104 → 126
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_001308215.2 → NP_001295144.1  zinc finger protein 346 isoform d

    See identical proteins and their annotated locations for NP_001295144.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (d) that is shorter than isoform a.
    Source sequence(s)
    AC027317, BU860103, DA789054, DB548047
    Conserved Domains (2) summary
    smart00451
    Location:135 → 164
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:136 → 158
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. NM_001308216.2 → NP_001295145.1  zinc finger protein 346 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks three alternate exons that result in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (e) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AC027317, DA169130, DA789054, DB548047
    Conserved Domains (1) summary
    smart00451
    Location:71 → 104
    ZnF_U1; U1-like zinc finger

  5. NM_001308218.2 → NP_001295147.1  zinc finger protein 346 isoform f

    See identical proteins and their annotated locations for NP_001295147.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks three alternate exons and uses an alternate splice site, resulting in the loss of an in-frame segment in the 5' and central coding regions, compared to variant 1. The encoded isoform (f) is shorter than isoform a.
    Source sequence(s)
    AC027317, AK297448, DB548047
    Consensus CDS
    CCDS83053.1
    UniProtKB/TrEMBL
    B7Z4J8
    Related
    ENSP00000423515.1, ENST00000506693.5
    Conserved Domains (3) summary
    smart00451
    Location:84 → 118
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:89 → 111
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:143 → 165
    zf-met; Zinc-finger of C2H2 type

  6. NM_001308219.2 → NP_001295148.1  zinc finger protein 346 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks three alternate exons and contains an alternate 3' terminal exon, resulting in a frameshift in the 3' coding region and an alternate 3' UTR, compared to variant 1. The encoded isoform (g) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AK131469, AK297584, BX331331, CR627467, DA789054, DB340780
    UniProtKB/Swiss-Prot
    Q9UL40
    UniProtKB/TrEMBL
    B7Z4N4
    Conserved Domains (1) summary
    smart00451
    Location:71 → 104
    ZnF_U1; U1-like zinc finger

  7. NM_001308221.2 → NP_001295150.1  zinc finger protein 346 isoform h

    See identical proteins and their annotated locations for NP_001295150.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks four alternate exons that result in the loss of an in-frame segment in the 5' and central coding regions, compared to variant 1. The encoded isoform (h) is shorter than isoform a. Both variants 8 and 9 encode isoform h.
    Source sequence(s)
    AC027317, DA789054, DB548047, DR003225
    Consensus CDS
    CCDS83054.1
    UniProtKB/TrEMBL
    B7Z4N4
    Conserved Domains (2) summary
    sd00020
    Location:65 → 87
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:65 → 87
    zf-met; Zinc-finger of C2H2 type

  8. NM_001308223.2 → NP_001295152.1  zinc finger protein 346 isoform h

    See identical proteins and their annotated locations for NP_001295152.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) lacks four alternate exons that result in the loss of an in-frame segment in the 5' and central coding regions, and it also contains an alternate 3' terminal exon and thus differs in the 3' UTR, compared to variant 1. The encoded isoform (h) is shorter than isoform a. Both variants 8 and 9 encode isoform h.
    Source sequence(s)
    AK131469, AK297584, CR627467, DB340780
    Consensus CDS
    CCDS83054.1
    UniProtKB/TrEMBL
    B7Z4N4
    Related
    ENSP00000421089.1, ENST00000512315.5
    Conserved Domains (2) summary
    sd00020
    Location:65 → 87
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:65 → 87
    zf-met; Zinc-finger of C2H2 type

  9. NM_001363713.2 → NP_001350642.1  zinc finger protein 346 isoform i

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (i) has the same N- and C-termini and is longer compared to isoform a.
    Source sequence(s)
    AC027314, AC027317
    Consensus CDS
    CCDS87353.1
    UniProtKB/TrEMBL
    D6RJ07
    Conserved Domains (2) summary
    smart00451
    Location:198 → 232
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:203 → 225
    ZF_C2H2; C2H2 Zn finger [structural motif]

  10. NM_012279.4 → NP_036411.1  zinc finger protein 346 isoform a

    See identical proteins and their annotated locations for NP_036411.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform a.
    Source sequence(s)
    AC027317, AF083340, AL359576, DA789054, DB548047
    Consensus CDS
    CCDS4409.1
    UniProtKB/Swiss-Prot
    B7Z367, Q68CV9, Q6ZMW1, Q9UL40
    Related
    ENSP00000350869.3, ENST00000358149.8
    Conserved Domains (2) summary
    smart00451
    Location:182 → 216
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:136 → 158
    ZF_C2H2; C2H2 Zn finger [structural motif]

RNA

  1. NR_131773.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) lacks an alternate exon in the central region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC027317, AK300065, DA789054, DB548047

  2. NR_131774.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) lacks two alternate exons in the central region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC027317, AK300738, DA789054, DB548047

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    177022696..177081189
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534494.2 → XP_011532796.1  zinc finger protein 346 isoform X2

    Conserved Domains (2) summary
    smart00451
    Location:223 → 257
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:161 → 183
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_047417054.1 → XP_047273010.1  zinc finger protein 346 isoform X10

  3. XM_047417055.1 → XP_047273011.1  zinc finger protein 346 isoform X12

  4. XM_047417057.1 → XP_047273013.1  zinc finger protein 346 isoform X14

  5. XM_047417051.1 → XP_047273007.1  zinc finger protein 346 isoform X1

  6. XM_011534496.3 → XP_011532798.1  zinc finger protein 346 isoform X5

    Conserved Domains (2) summary
    smart00451
    Location:207 → 241
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:161 → 183
    ZF_C2H2; C2H2 Zn finger [structural motif]

  7. XM_005265864.4 → XP_005265921.1  zinc finger protein 346 isoform X11

    Conserved Domains (2) summary
    smart00451
    Location:160 → 189
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:161 → 183
    ZF_C2H2; C2H2 Zn finger [structural motif]

  8. XM_047417052.1 → XP_047273008.1  zinc finger protein 346 isoform X4

    UniProtKB/TrEMBL
    D6RJ07
    Related
    ENSP00000425725.1, ENST00000511834.5

  9. XM_017009297.3 → XP_016864786.1  zinc finger protein 346 isoform X6

  10. XM_017009299.3 → XP_016864788.1  zinc finger protein 346 isoform X8

  11. XM_011534495.4 → XP_011532797.1  zinc finger protein 346 isoform X3

    Conserved Domains (2) summary
    smart00451
    Location:223 → 257
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:161 → 183
    ZF_C2H2; C2H2 Zn finger [structural motif]

  12. XM_047417053.1 → XP_047273009.1  zinc finger protein 346 isoform X9

  13. XM_017009298.2 → XP_016864787.1  zinc finger protein 346 isoform X7

  14. XM_047417056.1 → XP_047273012.1  zinc finger protein 346 isoform X13

  15. XM_017009303.2 → XP_016864792.1  zinc finger protein 346 isoform X15

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    177565869..177624397
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054352257.1 → XP_054208232.1  zinc finger protein 346 isoform X2

  2. XM_054352265.1 → XP_054208240.1  zinc finger protein 346 isoform X10

  3. XM_054352267.1 → XP_054208242.1  zinc finger protein 346 isoform X12

  4. XM_054352269.1 → XP_054208244.1  zinc finger protein 346 isoform X14

  5. XM_054352256.1 → XP_054208231.1  zinc finger protein 346 isoform X1

  6. XM_054352260.1 → XP_054208235.1  zinc finger protein 346 isoform X5

  7. XM_054352266.1 → XP_054208241.1  zinc finger protein 346 isoform X11

  8. XM_054352259.1 → XP_054208234.1  zinc finger protein 346 isoform X4

    UniProtKB/TrEMBL
    D6RJ07

  9. XM_054352261.1 → XP_054208236.1  zinc finger protein 346 isoform X6

  10. XM_054352263.1 → XP_054208238.1  zinc finger protein 346 isoform X8

  11. XM_054352258.1 → XP_054208233.1  zinc finger protein 346 isoform X3

  12. XM_054352264.1 → XP_054208239.1  zinc finger protein 346 isoform X9

  13. XM_054352262.1 → XP_054208237.1  zinc finger protein 346 isoform X7

  14. XM_054352268.1 → XP_054208243.1  zinc finger protein 346 isoform X13

  15. XM_054352270.1 → XP_054208245.1  zinc finger protein 346 isoform X15

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UL40.1 GenPept UniProtKB/Swiss-Prot:Q9UL40

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