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Zfp445 zinc finger protein 445 [ Mus musculus (house mouse) ]

Gene ID: 235682, updated on 2-Nov-2024

Summary

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Official Symbol
Zfp445provided by MGI
Official Full Name
zinc finger protein 445provided by MGI
Primary source
MGI:MGI:2143340
See related
Ensembl:ENSMUSG00000047036 AllianceGenome:MGI:2143340
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ZNF168; Znf445; mszf29; mszf50
Summary
Enables chromatin binding activity and double-stranded methylated DNA binding activity. Involved in epigenetic programing of female pronucleus and negative regulation of gene expression via chromosomal CpG island methylation. Located in nucleus. Is expressed in several structures, including cartilage condensation; early conceptus; forebrain; head bone; and urinary system. Orthologous to human ZNF445 (zinc finger protein 445). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E18 (RPKM 31.5), CNS E14 (RPKM 28.7) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Zfp445 in Genome Data Viewer
Location:
9 F4; 9 73.18 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (122677988..122715916, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (122848910..122886851, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6814 Neighboring gene T cell activation inhibitor, mitochondrial Neighboring gene predicted gene, 35549 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:122775118-122775301 Neighboring gene zinc finger with KRAB and SCAN domains 7 Neighboring gene zinc finger protein 660 Neighboring gene zinc finger protein 105

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of KAP-1-associated complexes negatively regulating the Ey and β-major globin genes in the β-globin locus. Yang D, et al. J Proteomics, 2013 Mar 27. PMID 23291531
  2. ZNF445 is a primary regulator of genomic imprinting. Takahashi N, et al. Genes Dev, 2019 Jan 1. PMID 30602440, Free PMC Article
  3. Temporomandibular joint formation requires two distinct hedgehog-dependent steps. Purcell P, et al. Proc Natl Acad Sci U S A, 2009 Oct 27. PMID 19815519, Free PMC Article
  4. Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR. Agata Y, et al. Gene, 1998 Jun 15. PMID 9630514
  5. High-throughput screen for genes predominantly expressed in the ICM of mouse blastocysts by whole mount in situ hybridization. Yoshikawa T, et al. Gene Expr Patterns, 2006 Jan. PMID 16325481, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables double-stranded methylated DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables double-stranded methylated DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in epigenetic programing of female pronucleus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in epigenetic programing of female pronucleus IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in epigenetic programing of female pronucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of gene expression via chromosomal CpG island methylation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of gene expression via chromosomal CpG island methylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger protein 445

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359934.2 → NP_001346863.1  zinc finger protein 445 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125374
    UniProtKB/TrEMBL
    Q499F8
    Conserved Domains (4) summary
    smart00431
    Location:48 → 160
    SCAN; leucine rich region
    smart00349
    Location:231 → 289
    KRAB; krueppel associated box
    COG5048
    Location:566 → 995
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:648 → 668
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001359935.2 → NP_001346864.1  zinc finger protein 445 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125374
    Consensus CDS
    CCDS23648.1
    UniProtKB/Swiss-Prot
    A4FTX7, Q8K216, Q8R2V3
    UniProtKB/TrEMBL
    Q499F8
    Conserved Domains (4) summary
    smart00431
    Location:48 → 160
    SCAN; leucine rich region
    smart00349
    Location:219 → 277
    KRAB; krueppel associated box
    COG5048
    Location:554 → 983
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:636 → 656
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_001421540.1 → NP_001408469.1  zinc finger protein 445 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125374

  4. NM_001421541.1 → NP_001408470.1  zinc finger protein 445 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125374
    UniProtKB/Swiss-Prot
    A4FTX7, Q8K216, Q8R2V3

  5. NM_001421542.1 → NP_001408471.1  zinc finger protein 445 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125374
    UniProtKB/Swiss-Prot
    A4FTX7, Q8K216, Q8R2V3

  6. NM_173364.6 → NP_775540.4  zinc finger protein 445 isoform 1

    See identical proteins and their annotated locations for NP_775540.4

    Status: VALIDATED

    Source sequence(s)
    AC125374
    Consensus CDS
    CCDS23648.1
    UniProtKB/Swiss-Prot
    A4FTX7, Q8K216, Q8R2V3
    UniProtKB/TrEMBL
    Q499F8
    Related
    ENSMUSP00000151198.2, ENSMUST00000216063.2
    Conserved Domains (4) summary
    smart00431
    Location:48 → 160
    SCAN; leucine rich region
    smart00349
    Location:219 → 277
    KRAB; krueppel associated box
    COG5048
    Location:554 → 983
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:636 → 656
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    122677988..122715916 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512121.3 → XP_006512184.1  zinc finger protein 445 isoform X1

    See identical proteins and their annotated locations for XP_006512184.1

    UniProtKB/TrEMBL
    Q499F8
    Conserved Domains (4) summary
    smart00431
    Location:48 → 160
    SCAN; leucine rich region
    smart00349
    Location:231 → 289
    KRAB; krueppel associated box
    COG5048
    Location:566 → 995
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:648 → 668
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_036154922.1 → XP_036010815.1  zinc finger protein 445 isoform X2

    UniProtKB/Swiss-Prot
    A4FTX7, Q8K216, Q8R2V3
    UniProtKB/TrEMBL
    Q499F8
    Conserved Domains (4) summary
    smart00431
    Location:48 → 160
    SCAN; leucine rich region
    smart00349
    Location:219 → 277
    KRAB; krueppel associated box
    COG5048
    Location:554 → 983
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:636 → 656
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. XM_006512119.4 → XP_006512182.1  zinc finger protein 445 isoform X1

    See identical proteins and their annotated locations for XP_006512182.1

    UniProtKB/TrEMBL
    Q499F8
    Conserved Domains (4) summary
    smart00431
    Location:48 → 160
    SCAN; leucine rich region
    smart00349
    Location:231 → 289
    KRAB; krueppel associated box
    COG5048
    Location:566 → 995
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:648 → 668
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. XM_006512118.3 → XP_006512181.1  zinc finger protein 445 isoform X1

    See identical proteins and their annotated locations for XP_006512181.1

    UniProtKB/TrEMBL
    Q499F8
    Conserved Domains (4) summary
    smart00431
    Location:48 → 160
    SCAN; leucine rich region
    smart00349
    Location:231 → 289
    KRAB; krueppel associated box
    COG5048
    Location:566 → 995
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:648 → 668
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. XM_011242971.1 → XP_011241273.1  zinc finger protein 445 isoform X1

    See identical proteins and their annotated locations for XP_011241273.1

    UniProtKB/TrEMBL
    Q499F8
    Conserved Domains (4) summary
    smart00431
    Location:48 → 160
    SCAN; leucine rich region
    smart00349
    Location:231 → 289
    KRAB; krueppel associated box
    COG5048
    Location:566 → 995
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:648 → 668
    ZF_C2H2; C2H2 Zn finger [structural motif]

  6. XM_006512122.3 → XP_006512185.1  zinc finger protein 445 isoform X1

    See identical proteins and their annotated locations for XP_006512185.1

    UniProtKB/TrEMBL
    Q499F8
    Conserved Domains (4) summary
    smart00431
    Location:48 → 160
    SCAN; leucine rich region
    smart00349
    Location:231 → 289
    KRAB; krueppel associated box
    COG5048
    Location:566 → 995
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:648 → 668
    ZF_C2H2; C2H2 Zn finger [structural motif]

  7. XM_036154924.1 → XP_036010817.1  zinc finger protein 445 isoform X3

    Conserved Domains (2) summary
    COG5048
    Location:199 → 628
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:281 → 301
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R2V3.2 GenPept UniProtKB/Swiss-Prot:Q8R2V3

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