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DAPK2 death associated protein kinase 2 [ Homo sapiens (human) ]

Gene ID: 23604, updated on 5-Mar-2024

Summary

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Official Symbol
DAPK2provided by HGNC
Official Full Name
death associated protein kinase 2provided by HGNC
Primary source
HGNC:HGNC:2675
See related
Ensembl:ENSG00000035664 MIM:616567; AllianceGenome:HGNC:2675
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DRP1; DRP-1
Summary
This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Overexpression of this gene was shown to induce cell apoptosis. It uses multiple polyadenylation sites. [provided by RefSeq, Jul 2008]
Expression
Broad expression in thyroid (RPKM 7.0), lung (RPKM 4.4) and 18 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
15q22.31
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (63907036..64046485, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (61714186..61853651, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (64199235..64338684, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:63958187-63958357 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:64006953-64007452 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:64006451-64006952 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:64014173-64014349 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:64057331-64058088 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:64058904-64059404 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6522 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:64107893-64108654 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:64114122-64114622 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:64125303-64126168 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:64126169-64127032 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9542 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:64171093-64171988 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9543 Neighboring gene Sharpr-MPRA regulatory region 4498 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:64186155-64186656 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9545 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9546 Neighboring gene microRNA 422a Neighboring gene uncharacterized LOC101928988 Neighboring gene Sharpr-MPRA regulatory region 12240 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:64264631-64265378 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:64277639-64278140 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:64290279-64290780 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6524 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9547 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9548 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:64318331-64318496 Neighboring gene NANOG hESC enhancer GRCh37_chr15:64330918-64331419 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9549 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9550 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6527 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6526 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6525 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:64342658-64343204 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9551 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9552 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:64385112-64385674 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9554 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9555 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9556 Neighboring gene Sharpr-MPRA regulatory region 7733 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9557 Neighboring gene cytosolic iron-sulfur assembly component 2A Neighboring gene sorting nexin 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Exosomal miR-133a-3p Derived from BMSCs Alleviates Cerebral Ischemia-Reperfusion Injury via Targeting DAPK2. Yang X, et al. Int J Nanomedicine, 2023. PMID 36636640, Free PMC Article
  2. Cigarette smoking induces aberrant N(6)-methyladenosine of DAPK2 to promote non-small cell lung cancer progression by activating NF-κB pathway. Jin M, et al. Cancer Lett, 2021 Oct 10. PMID 34298122
  3. miR-1285-3p Controls Colorectal Cancer Proliferation and Escape from Apoptosis through DAPK2. Villanova L, et al. Int J Mol Sci, 2020 Mar 31. PMID 32244500, Free PMC Article
  4. Upregulation of DAPK2 ameliorates oxidative damage and apoptosis of placental cells in hypertensive disorder complicating pregnancy by suppressing human placental microvascular endothelial cell autophagy through the mTOR signaling pathway. Wang Y, et al. Int J Biol Macromol, 2019 Jan. PMID 30243997
  5. Non-canonical activation of DAPK2 by AMPK constitutes a new pathway linking metabolic stress to autophagy. Shiloh R, et al. Nat Commun, 2018 May 1. PMID 29717115, Free PMC Article

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Exosomal miR-133a-3p Derived from BMSCs Alleviates Cerebral Ischemia-Reperfusion Injury via Targeting DAPK2.
    Title: Exosomal miR-133a-3p Derived from BMSCs Alleviates Cerebral Ischemia-Reperfusion Injury via Targeting DAPK2.
  2. Cigarette smoking induces aberrant N(6)-methyladenosine of DAPK2 to promote non-small cell lung cancer progression by activating NF-kappaB pathway.
    Title: Cigarette smoking induces aberrant N(6)-methyladenosine of DAPK2 to promote non-small cell lung cancer progression by activating NF-κB pathway.
  3. 14-3-3 proteins inactivate DAPK2 by promoting its dimerization and protecting key regulatory phosphosites.
    Title: 14-3-3 proteins inactivate DAPK2 by promoting its dimerization and protecting key regulatory phosphosites.
  4. miR-1285-3p Controls Colorectal Cancer Proliferation and Escape from Apoptosis through DAPK2.
    Title: miR-1285-3p Controls Colorectal Cancer Proliferation and Escape from Apoptosis through DAPK2.
  5. The intracellular signaling pathways that lead to Ser289 phosphorylation are mutually-exclusive and different for each kinase. In addition, Ser289 phosphorylation in fact enhances DAPK1 catalytic activity, similar to the effect on DAPK2. Thus, Ser289 phosphorylation activates both DAPK1 and DAPK2, but in response to different intracellular signaling pathways.
    Title: Ser289 phosphorylation activates both DAPK1 and DAPK2 but in response to different intracellular signaling pathways.
  6. remission effect of DAPK2 on placental cell oxidative damage and apoptosis in HDCP via mTOR activation
    Title: Upregulation of DAPK2 ameliorates oxidative damage and apoptosis of placental cells in hypertensive disorder complicating pregnancy by suppressing human placental microvascular endothelial cell autophagy through the mTOR signaling pathway.
  7. study reveals a unique calmodulin-independent mechanism for DAPK2 activation, critical to its function as a novel downstream effector of AMPK in autophagy
    Title: Non-canonical activation of DAPK2 by AMPK constitutes a new pathway linking metabolic stress to autophagy.
  8. This study suggests that miR-520g contributes to tumor progression and drug resistance by post-transcriptionally downregulating DAPK2 in patients with epithelial ovarian cancer
    Title: MicroRNA-520g promotes epithelial ovarian cancer progression and chemoresistance via DAPK2 repression.
  9. Thyroid hormone promotes selective autophagy via induction of DAPK2-SQSTM1 cascade, which in turn protects hepatocytes from diethylnitrosamine-induced hepatotoxicity or carcinogenesis.
    Title: Thyroid hormone suppresses hepatocarcinogenesis via DAPK2 and SQSTM1-dependent selective autophagy.
  10. miR-520h suppresses Death-associated protein kinase 2 (DAPK2) expression, as restoring DAPK2 abolished miR-520h-promoted drug resistance, and knockdown of DAPK2 mitigated cell death caused by the depletion of miR-520h.
    Title: miR-520h is crucial for DAPK2 regulation and breast cancer progression.
Submit: New GeneRIF Correction See all GeneRIFs (27)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of death-associated protein kinase 2 (DAPK2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC119312

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables calmodulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in anoikis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in apoptotic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of eosinophil chemotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of neutrophil chemotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein autophosphorylation TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of apoptotic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of autophagy TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of intrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
  
located_in autophagosome lumen IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
death-associated protein kinase 2
Names
DAP kinase 2
NP_001350659.1
NP_001371926.1
NP_001371927.1
NP_001371928.1
NP_001371929.1
NP_001382208.1
NP_001382210.1
NP_001382211.1
NP_001382212.1
NP_001382213.1
NP_001382214.1
NP_001382215.1
NP_001382216.1
NP_001382217.1
NP_001382218.1
NP_001382219.1
NP_001382220.1
NP_001382221.1
NP_001382222.1
NP_055141.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363730.2 → NP_001350659.1  death-associated protein kinase 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC015914, AC021541, GU056176
    Consensus CDS
    CCDS86463.1
    Related
    ENSP00000484390.1, ENST00000612884.4
    Conserved Domains (1) summary
    cd14196
    Location:17 → 285
    STKc_DAPK2; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2

  2. NM_001384997.1 → NP_001371926.1  death-associated protein kinase 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC015914, AC021541
    Conserved Domains (1) summary
    cd14196
    Location:17 → 285
    STKc_DAPK2; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2

  3. NM_001384998.1 → NP_001371927.1  death-associated protein kinase 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC015914, AC021541
    Conserved Domains (1) summary
    cl21453
    Location:17 → 279
    PKc_like; Protein Kinases, catalytic domain

  4. NM_001384999.1 → NP_001371928.1  death-associated protein kinase 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC015914, AC021541
    Conserved Domains (1) summary
    cl21453
    Location:17 → 220
    PKc_like; Protein Kinases, catalytic domain

  5. NM_001385000.1 → NP_001371929.1  death-associated protein kinase 2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC015914, AC021541
    Conserved Domains (1) summary
    cl21453
    Location:1 → 130
    PKc_like; Protein Kinases, catalytic domain

  6. NM_001395279.1 → NP_001382208.1  death-associated protein kinase 2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC015914, AC021541
    Conserved Domains (1) summary
    cd14196
    Location:17 → 285
    STKc_DAPK2; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2

  7. NM_001395281.1 → NP_001382210.1  death-associated protein kinase 2 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC015914, AC021541
    Conserved Domains (1) summary
    cl21453
    Location:1 → 130
    PKc_like; Protein Kinases, catalytic domain

  8. NM_001395282.1 → NP_001382211.1  death-associated protein kinase 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC015914, AC021541
    Conserved Domains (1) summary
    cl21453
    Location:17 → 279
    PKc_like; Protein Kinases, catalytic domain

  9. NM_001395283.1 → NP_001382212.1  death-associated protein kinase 2 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC015914, AC021541
    Conserved Domains (1) summary
    cl21453
    Location:1 → 124
    PKc_like; Protein Kinases, catalytic domain

  10. NM_001395284.1 → NP_001382213.1  death-associated protein kinase 2 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC015914, AC021541
    Conserved Domains (1) summary
    cl21453
    Location:1 → 124
    PKc_like; Protein Kinases, catalytic domain

  11. NM_001395285.1 → NP_001382214.1  death-associated protein kinase 2 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC015914, AC021541
    Conserved Domains (1) summary
    cd14196
    Location:17 → 285
    STKc_DAPK2; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2

  12. NM_001395286.1 → NP_001382215.1  death-associated protein kinase 2 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC015914, AC021541
    UniProtKB/TrEMBL
    Q1RMF4
    Conserved Domains (1) summary
    cl21453
    Location:1 → 130
    PKc_like; Protein Kinases, catalytic domain

  13. NM_001395287.1 → NP_001382216.1  death-associated protein kinase 2 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC015914, AC021541
    UniProtKB/TrEMBL
    Q1RMF4
    Conserved Domains (1) summary
    cl21453
    Location:1 → 130
    PKc_like; Protein Kinases, catalytic domain

  14. NM_001395288.1 → NP_001382217.1  death-associated protein kinase 2 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC015914, AC021541
    Conserved Domains (1) summary
    cd14196
    Location:17 → 285
    STKc_DAPK2; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2

  15. NM_001395289.1 → NP_001382218.1  death-associated protein kinase 2 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC015914, AC021541
    Conserved Domains (1) summary
    cl21453
    Location:1 → 124
    PKc_like; Protein Kinases, catalytic domain

  16. NM_001395290.1 → NP_001382219.1  death-associated protein kinase 2 isoform 13 precursor

    Status: VALIDATED

    Source sequence(s)
    AC015914, AC021541
    Conserved Domains (1) summary
    cl21453
    Location:1 → 76
    PKc_like; Protein Kinases, catalytic domain

  17. NM_001395291.1 → NP_001382220.1  death-associated protein kinase 2 isoform 14

    Status: VALIDATED

    Source sequence(s)
    AC015914, AC021541
    Conserved Domains (1) summary
    cd14196
    Location:17 → 285
    STKc_DAPK2; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2

  18. NM_001395292.1 → NP_001382221.1  death-associated protein kinase 2 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC015914, AC021541
    Conserved Domains (1) summary
    cl21453
    Location:1 → 130
    PKc_like; Protein Kinases, catalytic domain

  19. NM_001395293.1 → NP_001382222.1  death-associated protein kinase 2 isoform 15

    Status: VALIDATED

    Source sequence(s)
    AC015914, AC021541
    Conserved Domains (1) summary
    cd14196
    Location:17 → 285
    STKc_DAPK2; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2

  20. NM_014326.5 → NP_055141.2  death-associated protein kinase 2 isoform 1

    See identical proteins and their annotated locations for NP_055141.2

    Status: VALIDATED

    Source sequence(s)
    AB018001, AC015914, AC021541, AF052941
    Consensus CDS
    CCDS10188.1
    UniProtKB/Swiss-Prot
    E9JGM7, O75892, Q24JS1, Q9UIK4
    Related
    ENSP00000408277.1, ENST00000457488.6
    Conserved Domains (1) summary
    cd14196
    Location:17 → 285
    STKc_DAPK2; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2

RNA

  1. NR_169522.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC015914, AC021541

  2. NR_169523.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC015914, AC021541

  3. NR_169524.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC015914, AC021541

  4. NR_172521.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC015914, AC021541

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    63907036..64046485 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    61714186..61853651 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UIK4.1 GenPept UniProtKB/Swiss-Prot:Q9UIK4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
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Tools
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