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HSPBP1 HSPA (Hsp70) binding protein 1 [ Homo sapiens (human) ]

Gene ID: 23640, updated on 3-Nov-2024

Summary

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Official Symbol
HSPBP1provided by HGNC
Official Full Name
HSPA (Hsp70) binding protein 1provided by HGNC
Primary source
HGNC:HGNC:24989
See related
Ensembl:ENSG00000133265 MIM:612939; AllianceGenome:HGNC:24989
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FES1
Summary
Enables molecular sequestering activity and ubiquitin protein ligase binding activity. Involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process and positive regulation of protein ubiquitination. Is active in extracellular space. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in brain (RPKM 7.8), kidney (RPKM 7.4) and 25 other tissues See more
Orthologs
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Genomic context

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See HSPBP1 in Genome Data Viewer
Location:
19q13.42
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (55262223..55280383, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (58356168..58375917, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (55773591..55791751, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene protein phosphatase 6 regulatory subunit 1 Neighboring gene microRNA 6802 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15079 Neighboring gene microRNA 6803 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15080 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15081 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15082 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15083 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15084 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:55768465-55768658 Neighboring gene Sharpr-MPRA regulatory region 13763 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15086 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15087 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:55781781-55782280 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15088 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:55789069-55789569 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15089 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11021 Neighboring gene BR serine/threonine kinase 1 Neighboring gene Sharpr-MPRA regulatory region 11129 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:55824387-55824912 Neighboring gene transmembrane protein 150B Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:55849388-55850162 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:55850163-55850936 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15090 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11022 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11023 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:55855204-55856008 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:55856009-55856814 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:55858005-55858699 Neighboring gene lysine methyltransferase 5C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. HspBP1 and anti-HspBP1 levels in the serum of HIV-infected individuals are associated to the disease progression. Ceccin ADF, et al. J Appl Microbiol, 2019 Aug. PMID 30786116
  2. HSP70 interacting protein prevents the accumulation of inclusions in polyglutamine disease. Howarth JL, et al. J Neurochem, 2009 Feb. PMID 19183265, Free PMC Article
  3. HspBP1 levels are elevated in breast tumor tissue and inversely related to tumor aggressiveness. Souza AP, et al. Cell Stress Chaperones, 2009 May. PMID 18987994, Free PMC Article
  4. Anticancer drugs up-regulate HspBP1 and thereby antagonize the prosurvival function of Hsp70 in tumor cells. Tanimura S, et al. J Biol Chem, 2007 Dec 7. PMID 17855353
  5. Hsp70 protects against UVB induced apoptosis by preventing release of cathepsins and cytochrome c in human melanocytes. Bivik C, et al. Carcinogenesis, 2007 Mar. PMID 16950797

See all (118) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HspBP1 is a dual function regulatory protein that controls both DNA repair and apoptosis in breast cancer cells.
    Title: HspBP1 is a dual function regulatory protein that controls both DNA repair and apoptosis in breast cancer cells.
  2. HSPBP1 facilitates cellular RLR-mediated antiviral response by inhibiting the K48-linked ubiquitination of RIG-I.
    Title: HSPBP1 facilitates cellular RLR-mediated antiviral response by inhibiting the K48-linked ubiquitination of RIG-I.
  3. The Co-Chaperone HspBP1 Is a Novel Component of Stress Granules that Regulates Their Formation.
    Title: The Co-Chaperone HspBP1 Is a Novel Component of Stress Granules that Regulates Their Formation.
  4. Circulating HspBp1 is associated with progression of HIV infection and can be used as a new marker to predict the prognosis and management of HIV infection
    Title: HspBP1 and anti-HspBP1 levels in the serum of HIV-infected individuals are associated to the disease progression.
  5. Findings indicate a critical role of HspBP1 in differential CHIP/Hsp70 activities in neuronal and glial cells and the greater neuronal vulnerability to misfolded proteins in neurodegenerative diseases.
    Title: Differential HspBP1 expression accounts for the greater vulnerability of neurons than astrocytes to misfolded proteins.
  6. downregulation of Hsp70 and HspBP1 represents a unique feature of patients with preterm prelabor rupture of membranes
    Title: Expression profile of heat shock proteins in placental tissues of patients with preterm prelabor rupture of membranes and spontaneous preterm labor with intact membranes.
  7. our results clearly show that HspBP1 acts as an endogenous negative regulator of HIV-1 gene-expression and replication by suppressing NF-kappaB-mediated activation of viral transcription.
    Title: HSP70 binding protein 1 (HspBP1) suppresses HIV-1 replication by inhibiting NF-κB mediated activation of viral gene expression.
  8. Oxidative stress, inducing formation of disulfide bond, can affect stability and conformational mobility of human HspB1.
    Title: Effect of disulfide crosslinking on thermal transitions and chaperone-like activity of human small heat shock protein HspB1.
  9. BAG-1M and HspBP1 had differential impacts on the dynamic composition of steroid receptor folding complexes
    Title: Hsp70 cochaperones HspBP1 and BAG-1M differentially regulate steroid hormone receptor function.
  10. shown that HspBP1 binds Tag7 in the conditioned medium of tumor CSML0 cells, thereby preventing formation of the cytotoxic Tag7-Hsp70 complex
    Title: Extracellular HspBP1 inhibits formation of a cytotoxic Tag7-Hsp70 complex in vitro and in human serum.
Submit: New GeneRIF Correction See all GeneRIFs (25)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables adenyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables enzyme inhibitor activity TAS
Traceable Author Statement
more info
 PubMed 
enables molecular sequestering activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of protein ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein folding TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
hsp70-binding protein 1
Names
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
heat shock protein-binding protein 1
hsp70 interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130106.2 → NP_001123578.1  hsp70-binding protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001123578.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 3. Variants 1 and 2 encode the same isoform (2), which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AB020592, AF217996, BM853303, BU630679
    Consensus CDS
    CCDS33111.1
    UniProtKB/Swiss-Prot
    B3KQP0, B4DG11, O95351, Q6ZNU5, Q9NZL4
    Related
    ENSP00000255631.4, ENST00000255631.9
    Conserved Domains (2) summary
    sd00043
    Location:88 → 130
    ARM; armadillo repeat [structural motif]
    pfam08609
    Location:45 → 139
    Fes1; Nucleotide exchange factor Fes1

  2. NM_001297600.2 → NP_001284529.1  hsp70-binding protein 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes the longer isoform (1).
    Source sequence(s)
    AB020592, AF217996, AI859141, AK294358, DB500673
    UniProtKB/Swiss-Prot
    Q9NZL4
    Related
    ENSP00000467574.1, ENST00000587922.5
    Conserved Domains (3) summary
    cd00020
    Location:248 → 347
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam08609
    Location:91 → 185
    Fes1; Nucleotide exchange factor Fes1
    sd00043
    Location:134 → 176
    ARM; armadillo repeat [structural motif]

  3. NM_012267.5 → NP_036399.3  hsp70-binding protein 1 isoform 2

    See identical proteins and their annotated locations for NP_036399.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 3. Variants 1 and 2 encode the same isoform (2), which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AB020592, BM853303, BU630679
    Consensus CDS
    CCDS33111.1
    UniProtKB/Swiss-Prot
    B3KQP0, B4DG11, O95351, Q6ZNU5, Q9NZL4
    Related
    ENSP00000398244.1, ENST00000433386.7
    Conserved Domains (2) summary
    sd00043
    Location:88 → 130
    ARM; armadillo repeat [structural motif]
    pfam08609
    Location:45 → 139
    Fes1; Nucleotide exchange factor Fes1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    55262223..55280383 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526691.2 → XP_011524993.1  hsp70-binding protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011524993.1

    Conserved Domains (2) summary
    sd00043
    Location:88 → 130
    ARM; armadillo repeat [structural motif]
    pfam08609
    Location:45 → 139
    Fes1; Nucleotide exchange factor Fes1

  2. XM_024451436.2 → XP_024307204.1  hsp70-binding protein 1 isoform X1

    Conserved Domains (2) summary
    sd00043
    Location:88 → 130
    ARM; armadillo repeat [structural motif]
    pfam08609
    Location:45 → 139
    Fes1; Nucleotide exchange factor Fes1

  3. XM_017026544.3 → XP_016882033.1  hsp70-binding protein 1 isoform X2

    UniProtKB/Swiss-Prot
    B3KQP0, B4DG11, O95351, Q6ZNU5, Q9NZL4
    Conserved Domains (2) summary
    sd00043
    Location:88 → 130
    ARM; armadillo repeat [structural motif]
    pfam08609
    Location:45 → 139
    Fes1; Nucleotide exchange factor Fes1

  4. XM_005258701.4 → XP_005258758.1  hsp70-binding protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005258758.1

    Conserved Domains (2) summary
    sd00043
    Location:88 → 130
    ARM; armadillo repeat [structural motif]
    pfam08609
    Location:45 → 139
    Fes1; Nucleotide exchange factor Fes1

  5. XM_024451437.2 → XP_024307205.1  hsp70-binding protein 1 isoform X2

    UniProtKB/Swiss-Prot
    B3KQP0, B4DG11, O95351, Q6ZNU5, Q9NZL4
    Conserved Domains (2) summary
    sd00043
    Location:88 → 130
    ARM; armadillo repeat [structural motif]
    pfam08609
    Location:45 → 139
    Fes1; Nucleotide exchange factor Fes1

  6. XM_017026545.2 → XP_016882034.1  hsp70-binding protein 1 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    58356168..58375917 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320424.1 → XP_054176399.1  hsp70-binding protein 1 isoform X1

  2. XM_054320426.1 → XP_054176401.1  hsp70-binding protein 1 isoform X1

  3. XM_054320428.1 → XP_054176403.1  hsp70-binding protein 1 isoform X2

    UniProtKB/Swiss-Prot
    B3KQP0, B4DG11, O95351, Q6ZNU5, Q9NZL4

  4. XM_054320425.1 → XP_054176400.1  hsp70-binding protein 1 isoform X1

  5. XM_054320427.1 → XP_054176402.1  hsp70-binding protein 1 isoform X2

    UniProtKB/Swiss-Prot
    B3KQP0, B4DG11, O95351, Q6ZNU5, Q9NZL4

  6. XM_054320429.1 → XP_054176404.1  hsp70-binding protein 1 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NZL4.2 GenPept UniProtKB/Swiss-Prot:Q9NZL4

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