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TRIM29 tripartite motif containing 29 [ Homo sapiens (human) ]

Gene ID: 23650, updated on 7-Apr-2024

Summary

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Official Symbol
TRIM29provided by HGNC
Official Full Name
tripartite motif containing 29provided by HGNC
Primary source
HGNC:HGNC:17274
See related
Ensembl:ENSG00000137699 MIM:610658; AllianceGenome:HGNC:17274
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ATDC
Summary
The protein encoded by this gene belongs to the TRIM protein family. It has multiple zinc finger motifs and a leucine zipper motif. It has been proposed to form homo- or heterodimers which are involved in nucleic acid binding. Thus, it may act as a transcriptional regulatory factor involved in carcinogenesis and/or differentiation. It may also function in the suppression of radiosensitivity since it is associated with ataxia telangiectasia phenotype. [provided by RefSeq, Jul 2008]
Expression
Biased expression in esophagus (RPKM 274.4), skin (RPKM 264.0) and 4 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
11q23.3
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (120111286..120138113, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (120134138..120160951, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (119981994..120008821, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369527 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_19353 Neighboring gene NANOG hESC enhancer GRCh37_chr11:119926297-119926798 Neighboring gene MPRA-validated peak1494 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:119932166-119933158 Neighboring gene uncharacterized LOC105378956 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:119952219-119953418 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:119967440-119968306 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5635 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:119994383-119994890 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:119995312-119996511 Neighboring gene uncharacterized LOC105369529 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_19417 Neighboring gene uncharacterized LOC107984399 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3985 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5636 Neighboring gene uncharacterized LOC124902773

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. E3 ubiquitin ligase TRIM29 promotes pancreatic cancer growth and progression via stabilizing Yes-associated protein 1. Deng X, et al. J Transl Med, 2021 Aug 5. PMID 34353343, Free PMC Article
  2. TRIM29 Reverses Oxaliplatin Resistance of P53 Mutant Colon Cancer Cell. Lei G, et al. Can J Gastroenterol Hepatol, 2021. PMID 33824865, Free PMC Article
  3. Terminal keratinocyte differentiation in vitro is associated with a stable DNA methylome. Smits JPH, et al. Exp Dermatol, 2021 Aug. PMID 32681572, Free PMC Article
  4. TRIM29 prevents hepatocellular carcinoma progression by inhibiting Wnt/β-catenin signaling pathway. Xu M, et al. Acta Biochim Biophys Sin (Shanghai), 2019 Jan 1. PMID 30566565
  5. Loss of TRIM29 Alters Keratin Distribution to Promote Cell Invasion in Squamous Cell Carcinoma. Yanagi T, et al. Cancer Res, 2018 Dec 15. PMID 30389700

See all (102) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TRIM29 modulates proteins involved in PTEN/AKT/mTOR and JAK2/STAT3 signaling pathway and suppresses the progression of hepatocellular carcinoma.
    Title: TRIM29 modulates proteins involved in PTEN/AKT/mTOR and JAK2/STAT3 signaling pathway and suppresses the progression of hepatocellular carcinoma.
  2. TRIM29 promotes the progression of colorectal cancer by suppressing EZH2 degradation.
    Title: TRIM29 promotes the progression of colorectal cancer by suppressing EZH2 degradation.
  3. TRIM29 promotes antitumor immunity through enhancing IGF2BP1 ubiquitination and subsequent PD-L1 downregulation in gastric cancer.
    Title: TRIM29 promotes antitumor immunity through enhancing IGF2BP1 ubiquitination and subsequent PD-L1 downregulation in gastric cancer.
  4. NAP1L5 facilitates pancreatic ductal adenocarcinoma progression via TRIM29-mediated ubiquitination of PHLPP1.
    Title: NAP1L5 facilitates pancreatic ductal adenocarcinoma progression via TRIM29-mediated ubiquitination of PHLPP1.
  5. lncRNA ELFN1-AS1 upregulates TRIM29 by suppressing miR-211-3p to promote gastric cancer progression.
    Title: lncRNA ELFN1-AS1 upregulates TRIM29 by suppressing miR-211-3p to promote gastric cancer progression.
  6. Classification of early age facial growth pattern and identification of the genetic basis in two Korean populations.
    Title: Classification of early age facial growth pattern and identification of the genetic basis in two Korean populations.
  7. Terminal keratinocyte differentiation in vitro is associated with a stable DNA methylome.
    Title: Terminal keratinocyte differentiation in vitro is associated with a stable DNA methylome.
  8. TRIM29 regulates the SETBP1/SET/PP2A axis via transcription factor VEZF1 to promote progression of ovarian cancer.
    Title: TRIM29 regulates the SETBP1/SET/PP2A axis via transcription factor VEZF1 to promote progression of ovarian cancer.
  9. TRIM29 is required for efficient recruitment of 53BP1 in response to DNA double-strand breaks in vertebrate cells.
    Title: TRIM29 is required for efficient recruitment of 53BP1 in response to DNA double-strand breaks in vertebrate cells.
  10. E3 ubiquitin ligase TRIM29 promotes pancreatic cancer growth and progression via stabilizing Yes-associated protein 1.
    Title: E3 ubiquitin ligase TRIM29 promotes pancreatic cancer growth and progression via stabilizing Yes-associated protein 1.
Submit: New GeneRIF Correction See all GeneRIFs (55)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study identifies a gene network of ADAMTS genes in the predisposition to pediatric stroke.
EBI GWAS Catalog
Genetic variants near PDGFRA are associated with corneal curvature in Australians.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of tripartite motif containing 29 (TRIM29) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ36085

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cadherin binding involved in cell-cell adhesion HDA PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables p53 binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of protein localization to nucleus IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in adherens junction HDA PubMed 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tripartite motif-containing protein 29
Names
ataxia-telangiectasia group D-associated protein
tripartite motif protein TRIM29

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330382.2 → NP_001317311.1  tripartite motif-containing protein 29 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AK299459, AP001360, BM996078, CU450129, DC420658
    Consensus CDS
    CCDS81637.1
    UniProtKB/TrEMBL
    B7Z5V5, E9PRL4
    Related
    ENSP00000436015.1, ENST00000529044.5

  2. NM_012101.4 → NP_036233.2  tripartite motif-containing protein 29 isoform 1

    See identical proteins and their annotated locations for NP_036233.2

    Status: REVIEWED

    Source sequence(s)
    AP000679, BC017352
    Consensus CDS
    CCDS8428.1
    UniProtKB/Swiss-Prot
    Q14134, Q96AA9, Q9BZY7
    UniProtKB/TrEMBL
    Q53G41
    Related
    ENSP00000343129.5, ENST00000341846.10
    Conserved Domains (2) summary
    smart00336
    Location:220 → 260
    BBOX; B-Box-type zinc finger
    cl27218
    Location:273 → 355
    OmpH; Outer membrane protein (OmpH-like)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    120111286..120138113 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047426689.1 → XP_047282645.1  tripartite motif-containing protein 29 isoform X1

  2. XM_047426688.1 → XP_047282644.1  tripartite motif-containing protein 29 isoform X5

  3. XM_005271490.2 → XP_005271547.1  tripartite motif-containing protein 29 isoform X4

    See identical proteins and their annotated locations for XP_005271547.1

    UniProtKB/TrEMBL
    B7Z5V5, B7Z8U9
    Conserved Domains (1) summary
    pfam01442
    Location:1 → 107
    Apolipoprotein; Apolipoprotein A1/A4/E domain

  4. XM_011542733.2 → XP_011541035.1  tripartite motif-containing protein 29 isoform X3

    UniProtKB/TrEMBL
    B7Z5V5
    Conserved Domains (1) summary
    cl02488
    Location:20 → 99
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  5. XM_017017453.2 → XP_016872942.1  tripartite motif-containing protein 29 isoform X2

    UniProtKB/TrEMBL
    B7Z5V5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    120134138..120160951 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054368258.1 → XP_054224233.1  tripartite motif-containing protein 29 isoform X1

  2. XM_054368261.1 → XP_054224236.1  tripartite motif-containing protein 29 isoform X4

    UniProtKB/TrEMBL
    B7Z8U9

  3. XM_054368260.1 → XP_054224235.1  tripartite motif-containing protein 29 isoform X3

  4. XM_054368259.1 → XP_054224234.1  tripartite motif-containing protein 29 isoform X2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_058193.1: Suppressed sequence

    Description
    NM_058193.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14134.2 GenPept UniProtKB/Swiss-Prot:Q14134

Gene LinkOut

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