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Kcns3 potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3 [ Mus musculus (house mouse) ]

Gene ID: 238076, updated on 28-Oct-2024

Summary

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Official Symbol
Kcns3provided by MGI
Official Full Name
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3provided by MGI
Primary source
MGI:MGI:1098804
See related
Ensembl:ENSMUSG00000043673 AllianceGenome:MGI:1098804
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable potassium channel regulator activity. Predicted to be involved in action potential and potassium ion transmembrane transport. Predicted to be located in Golgi apparatus; cytosol; and plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in membrane. Is expressed in dentate gyrus subgranular zone. Orthologous to human KCNS3 (potassium voltage-gated channel modifier subfamily S member 3). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Broad expression in subcutaneous fat pad adult (RPKM 2.9), genital fat pad adult (RPKM 2.7) and 16 other tissues See more
Orthologs
human all
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Genomic context

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See Kcns3 in Genome Data Viewer
Location:
12 A1.1; 12 5.58 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (11140738..11201186, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (11090202..11151168, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene phosphoglycerate kinase-1, related sequence-7 Neighboring gene RIKEN cDNA 7420701I03 gene Neighboring gene STARR-seq mESC enhancer starr_31535 Neighboring gene STARR-seq mESC enhancer starr_31536 Neighboring gene RIKEN cDNA 9530020I12 gene Neighboring gene STARR-seq mESC enhancer starr_31537 Neighboring gene STARR-seq mESC enhancer starr_31538 Neighboring gene mesogenin 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Kcns3 deficiency disrupts Parvalbumin neuron physiology in mouse prefrontal cortex: Implications for the pathophysiology of schizophrenia. Miyamae T, et al. Neurobiol Dis, 2021 Jul. PMID 33940180, Free PMC Article
  2. Sensory Neuron Diversity in the Inner Ear Is Shaped by Activity. Shrestha BR, et al. Cell, 2018 Aug 23. PMID 30078709, Free PMC Article
  3. Fine mapping of Ath6, a quantitative trait locus for atherosclerosis in mice. Purcell MK, et al. Mamm Genome, 2001 Jul. PMID 11420610
  4. Regulation of otocyst patterning by Tbx2 and Tbx3 is required for inner ear morphogenesis in the mouse. Kaiser M, et al. Development, 2021 Apr 15. PMID 33795231
  5. Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development. Harrell MD, et al. Physiol Genomics, 2007 Feb 12. PMID 16985003

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Kcns3 deficiency disrupts Parvalbumin neuron physiology in mouse prefrontal cortex: Implications for the pathophysiology of schizophrenia.
    Title: Kcns3 deficiency disrupts Parvalbumin neuron physiology in mouse prefrontal cortex: Implications for the pathophysiology of schizophrenia.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 

General gene information

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Markers

Homology

Clone Names

  • D12Ertd137e

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables potassium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables voltage-gated potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in action potential IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein homooligomerization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of voltage-gated potassium channel complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
potassium voltage-gated channel subfamily S member 3
Names
voltage-gated potassium channel subunit Kv9.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168564.2 → NP_001162036.1  potassium voltage-gated channel subfamily S member 3

    See identical proteins and their annotated locations for NP_001162036.1

    Status: VALIDATED

    Source sequence(s)
    AC120406
    Consensus CDS
    CCDS25813.1
    UniProtKB/Swiss-Prot
    Q8BQZ8
    Related
    ENSMUSP00000129412.2, ENSMUST00000164495.9
    Conserved Domains (2) summary
    cd18428
    Location:15 → 122
    BTB_POZ_KCNS3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 3 (KCNS3)
    pfam00520
    Location:184 → 417
    Ion_trans; Ion transport protein

  2. NM_001413254.1 → NP_001400183.1  potassium voltage-gated channel subfamily S member 3

    Status: VALIDATED

    Source sequence(s)
    AC120406
    UniProtKB/Swiss-Prot
    Q8BQZ8

  3. NM_001413255.1 → NP_001400184.1  potassium voltage-gated channel subfamily S member 3

    Status: VALIDATED

    Source sequence(s)
    AC120406
    UniProtKB/Swiss-Prot
    Q8BQZ8

  4. NM_001413256.1 → NP_001400185.1  potassium voltage-gated channel subfamily S member 3

    Status: VALIDATED

    Source sequence(s)
    AC120406
    UniProtKB/Swiss-Prot
    Q8BQZ8
    Related
    ENSMUSP00000152026.2, ENSMUST00000217974.2

  5. NM_001413257.1 → NP_001400186.1  potassium voltage-gated channel subfamily S member 3

    Status: VALIDATED

    Source sequence(s)
    AC120406
    UniProtKB/Swiss-Prot
    Q8BQZ8

  6. NM_001413258.1 → NP_001400187.1  potassium voltage-gated channel subfamily S member 3

    Status: VALIDATED

    Source sequence(s)
    AC120406
    UniProtKB/Swiss-Prot
    Q8BQZ8

  7. NM_001413259.1 → NP_001400188.1  potassium voltage-gated channel subfamily S member 3

    Status: VALIDATED

    Source sequence(s)
    AC120406
    UniProtKB/Swiss-Prot
    Q8BQZ8

  8. NM_173417.4 → NP_775593.1  potassium voltage-gated channel subfamily S member 3

    See identical proteins and their annotated locations for NP_775593.1

    Status: VALIDATED

    Source sequence(s)
    AC120406
    Consensus CDS
    CCDS25813.1
    UniProtKB/Swiss-Prot
    Q8BQZ8
    Related
    ENSMUSP00000060706.2, ENSMUST00000055673.2
    Conserved Domains (2) summary
    cd18428
    Location:15 → 122
    BTB_POZ_KCNS3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 3 (KCNS3)
    pfam00520
    Location:184 → 417
    Ion_trans; Ion transport protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    11140738..11201186 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011243867.1 → XP_011242169.1  potassium voltage-gated channel subfamily S member 3 isoform X2

    See identical proteins and their annotated locations for XP_011242169.1

    Conserved Domains (2) summary
    cl38908
    Location:4 → 40
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    pfam00520
    Location:102 → 335
    Ion_trans; Ion transport protein

  2. XM_011243866.3 → XP_011242168.1  potassium voltage-gated channel subfamily S member 3 isoform X1

    See identical proteins and their annotated locations for XP_011242168.1

    UniProtKB/Swiss-Prot
    Q8BQZ8
    Conserved Domains (2) summary
    cd18428
    Location:15 → 122
    BTB_POZ_KCNS3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 3 (KCNS3)
    pfam00520
    Location:184 → 417
    Ion_trans; Ion transport protein

  3. XM_006515080.4 → XP_006515143.1  potassium voltage-gated channel subfamily S member 3 isoform X1

    See identical proteins and their annotated locations for XP_006515143.1

    UniProtKB/Swiss-Prot
    Q8BQZ8
    Conserved Domains (2) summary
    cd18428
    Location:15 → 122
    BTB_POZ_KCNS3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 3 (KCNS3)
    pfam00520
    Location:184 → 417
    Ion_trans; Ion transport protein

  4. XM_006515082.4 → XP_006515145.1  potassium voltage-gated channel subfamily S member 3 isoform X2

    See identical proteins and their annotated locations for XP_006515145.1

    Conserved Domains (2) summary
    cl38908
    Location:4 → 40
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    pfam00520
    Location:102 → 335
    Ion_trans; Ion transport protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BQZ8.1 GenPept UniProtKB/Swiss-Prot:Q8BQZ8

Gene LinkOut

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