Gpr135 G protein-coupled receptor 135 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gpr135provided by MGI
Official Full Name: G protein-coupled receptor 135provided by MGI
Primary source: MGI:MGI:2676315
See related: Ensembl:ENSMUSG00000043398 AllianceGenome:MGI:2676315
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PAFR
Summary: Predicted to enable G protein-coupled receptor activity and arrestin family protein binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in endosome membrane. Predicted to be active in endosome and plasma membrane. Orthologous to human GPR135 (G protein-coupled receptor 135). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs: human all
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Genomic context

Location:: 12 C3; 12 30.2 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (72114748..72117875, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (72067974..72071101, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:493300

NoName (e-PCR)
- UniSTS:490751

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables arrestin family protein binding	IEA Inferred from Electronic Annotation more info
enables arrestin family protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: G-protein coupled receptor 135

Names: probable G-protein coupled receptor 135

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_181752.2 → NP_861417.1 G-protein coupled receptor 135

See identical proteins and their annotated locations for NP_861417.1

Status: VALIDATED

Source sequence(s)

BC062104, CR974486

Consensus CDS

CCDS25965.1

UniProtKB/Swiss-Prot

Q7TQP2

UniProtKB/TrEMBL

A3KMD9, A7E1Z8, Q1LZL6

Related

ENSMUSP00000058762.5, ENSMUST00000050649.6

Conserved Domains (2) summary

pfam00001
Location:89 → 350

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl10012
Location:251 → 282

DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily