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Btbd7 BTB domain containing 7 [ Mus musculus (house mouse) ]

Gene ID: 238386, updated on 2-Nov-2024

Summary

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Official Symbol
Btbd7provided by MGI
Official Full Name
BTB domain containing 7provided by MGI
Primary source
MGI:MGI:1917858
See related
Ensembl:ENSMUSG00000041702 AllianceGenome:MGI:1917858
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FUP1; mKIAA1525; 8030448M07; 5730507E09Rik; E130118E17Rik
Summary
Acts upstream of or within regulation of branching involved in salivary gland morphogenesis. Located in nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; and submandibular gland primordium. Orthologous to human BTBD7 (BTB domain containing 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in limb E14.5 (RPKM 6.7), bladder adult (RPKM 6.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Btbd7 in Genome Data Viewer
Location:
12 E; 12 52.25 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (102747056..102844733, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (102780797..102878471, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_33118 Neighboring gene predicted gene 20604 Neighboring gene STARR-seq mESC enhancer starr_33119 Neighboring gene GON7 subunit of KEOPS complex Neighboring gene ubiquitin protein ligase E3 component n-recognin 7 (putative) Neighboring gene cytochrome c oxidase subunit 7C, mitochondrial pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E8503 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene cytochrome c oxidase subunit 8C Neighboring gene unc-79 homolog Neighboring gene STARR-seq mESC enhancer starr_33121

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. FUP1, a gene associated with hepatocellular carcinoma, stimulates NIH3T3 cell proliferation and tumor formation in nude mice. Pan W, et al. Biochem Biophys Res Commun, 2001 Sep 7. PMID 11527404
  2. Involvement of the T-box transcription factor Brachyury in early-stage embryonic mouse salivary gland. Hayashi K, et al. Biochem Biophys Res Commun, 2016 Sep 2. PMID 27369076
  3. Btbd7 regulates epithelial cell dynamics and branching morphogenesis. Onodera T, et al. Science, 2010 Jul 30. PMID 20671187, Free PMC Article
  4. Adamts18 Deficiency Causes Spontaneous SMG Fibrogenesis in Adult Mice. Yang N, et al. J Dent Res, 2022 Feb. PMID 34323105
  5. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

General gene information

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Markers

Homology

Clone Names

  • MGC49574

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in morphogenesis of a branching epithelium IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of branching involved in salivary gland morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of branching involved in salivary gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
BTB/POZ domain-containing protein 7
Names
BTB (POZ) domain containing 7
function-unkown protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001377026.1 → NP_001363955.1  BTB/POZ domain-containing protein 7

    Status: VALIDATED

    Source sequence(s)
    AC122367, AC132315
    UniProtKB/Swiss-Prot
    Q80TC3, Q8BZY9, Q8CFE5
    Related
    ENSMUSP00000046951.7, ENSMUST00000045652.8
    Conserved Domains (3) summary
    cd18283
    Location:140 → 231
    BTB1_POZ_BTBD7; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7)
    cd18284
    Location:245 → 392
    BTB2_POZ_BTBD7; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7)
    cd18489
    Location:397 → 494
    BACK_BTBD7; BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 7 (BTBD7)

  2. NM_172806.3 → NP_766394.2  BTB/POZ domain-containing protein 7

    See identical proteins and their annotated locations for NP_766394.2

    Status: VALIDATED

    Source sequence(s)
    AC122367, AC132315
    Consensus CDS
    CCDS26125.1
    UniProtKB/Swiss-Prot
    Q80TC3, Q8BZY9, Q8CFE5
    Related
    ENSMUSP00000152426.2, ENSMUST00000223554.2
    Conserved Domains (3) summary
    cd18283
    Location:140 → 231
    BTB1_POZ_BTBD7; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7)
    cd18284
    Location:245 → 392
    BTB2_POZ_BTBD7; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7)
    cd18489
    Location:397 → 494
    BACK_BTBD7; BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 7 (BTBD7)

RNA

  1. NR_165048.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC122367, AC132315

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    102747056..102844733 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157405.1 → XP_036013298.1  BTB/POZ domain-containing protein 7 isoform X1

  2. XM_036157406.1 → XP_036013299.1  BTB/POZ domain-containing protein 7 isoform X2

    Conserved Domains (2) summary
    cd18283
    Location:140 → 231
    BTB1_POZ_BTBD7; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7)
    cd18284
    Location:245 → 388
    BTB2_POZ_BTBD7; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7)

RNA

  1. XR_004937501.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CFE5.1 GenPept UniProtKB/Swiss-Prot:Q8CFE5

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