Adam6a a disintegrin and metallopeptidase domain 6A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adam6aprovided by MGI
Official Full Name: a disintegrin and metallopeptidase domain 6Aprovided by MGI
Primary source: MGI:MGI:2676316
See related: Ensembl:ENSMUSG00000043945 AllianceGenome:MGI:2676316
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Adam6; tMDCIV
Summary: Predicted to enable metalloendopeptidase activity. Predicted to be involved in male gonad development and proteolysis. Located in external side of plasma membrane and sperm head plasma membrane. Part of protein-containing complex. Orthologous to human ADAM6 (ADAM metallopeptidase domain 6 (pseudogene)). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: 12 F1; 12 62.12 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (113507528..113510034)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (113543908..113546414)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lack of tyrosylprotein sulfotransferase-2 activity results in altered sperm-egg interactions and loss of ADAM3 and ADAM6 in epididymal sperm.
Title: Lack of tyrosylprotein sulfotransferase-2 activity results in altered sperm-egg interactions and loss of ADAM3 and ADAM6 in epididymal sperm.
The levels of ADAM4 and ADAM6 are dramatically reduced in Adam2 and Adam3 knockout sperm defective in various fertilization processes.
Title: Comprehensive analysis of reproductive ADAMs: relationship of ADAM4 and ADAM6 with an ADAM complex required for fertilization in mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in male gonad development	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in sperm head plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in sperm head plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: a disintegrin and metalloprotease domain 6

Names: a disintegrin and metallopeptidase domain 6; disintegrin and metalloproteinase domain 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_005838.1

Range

296312..298818

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_174885.3 → NP_777479.2 a disintegrin and metalloprotease domain 6

See identical proteins and their annotated locations for NP_777479.2

Status: VALIDATED

Source sequence(s)

AC073553

Consensus CDS

CCDS26208.1

UniProtKB/TrEMBL

B2RSY5, Q8CGQ1

Related

ENSMUSP00000059315.2, ENSMUST00000053086.3

Conserved Domains (4) summary

smart00608
Location:503 → 638

ACR; ADAM Cysteine-Rich Domain

cd04269
Location:217 → 406

ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

pfam00200
Location:427 → 500

Disintegrin; Disintegrin

pfam01562
Location:69 → 166

Pep_M12B_propep; Reprolysin family propeptide