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Cdc20b cell division cycle 20B [ Mus musculus (house mouse) ]

Gene ID: 238896, updated on 28-Oct-2024

Summary

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Official Symbol
Cdc20bprovided by MGI
Official Full Name
cell division cycle 20Bprovided by MGI
Primary source
MGI:MGI:3644472
See related
Ensembl:ENSMUSG00000078926 AllianceGenome:MGI:3644472
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EG238896; EG622422
Summary
Predicted to enable anaphase-promoting complex binding activity and ubiquitin ligase activator activity. Involved in de novo centriole assembly. Located in deuterosome. Orthologous to human CDC20B (cell division cycle 20B). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in testis adult (RPKM 2.0), CNS E14 (RPKM 0.2) and 3 other tissues See more
Orthologs
human all
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Genomic context

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See Cdc20b in Genome Data Viewer
Location:
13 D2.2; 13 63.93 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (113171514..113257553)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (113034975..113121019)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene cyclin O Neighboring gene multiciliate differentiation and DNA synthesis associated cell cycle protein Neighboring gene STARR-positive B cell enhancer ABC_E5420 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:113814136-113814301 Neighboring gene microRNA 449c Neighboring gene microRNA 449b Neighboring gene microRNA 449a Neighboring gene glutathione peroxidase 8 (putative) Neighboring gene granzyme A Neighboring gene RIKEN cDNA 1700084D21 gene Neighboring gene granzyme K

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CDC20B is required for deuterosome-mediated centriole production in multiciliated cells. Revinski DR, et al. Nat Commun, 2018 Nov 7. PMID 30405130, Free PMC Article
  2. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CDC20B protein associates to deuterosomes and is required for centriole release and subsequent cilia production.
    Title: CDC20B is required for deuterosome-mediated centriole production in multiciliated cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables anaphase-promoting complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables anaphase-promoting complex binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin ligase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in anaphase-promoting complex-dependent catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in de novo centriole assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in de novo centriole assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of anaphase-promoting complex-dependent catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of anaphase-promoting complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in deuterosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in deuterosome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cell division cycle protein 20 homolog B
Names
cell division cycle 20 homolog B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001281487.1 → NP_001268416.1  cell division cycle protein 20 homolog B

    Status: VALIDATED

    Source sequence(s)
    AC159207, AC165265
    Consensus CDS
    CCDS59591.1
    UniProtKB/Swiss-Prot
    D3Z3I0
    UniProtKB/TrEMBL
    M0QWN1
    Related
    ENSMUSP00000104867.2, ENSMUST00000109244.9
    Conserved Domains (3) summary
    COG2319
    Location:230 → 518
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:236 → 273
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:237 → 517
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    113171514..113257553
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247263.2 → XP_030103123.1  cell division cycle protein 20 homolog B isoform X8

    UniProtKB/TrEMBL
    M0QWN1
    Conserved Domains (2) summary
    COG2319
    Location:184 → 510
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:208 → 245
    7WD40; WD40 repeat [structural motif]

  2. XM_011244659.3 → XP_011242961.1  cell division cycle protein 20 homolog B isoform X1

    UniProtKB/TrEMBL
    M0QWN1
    Conserved Domains (2) summary
    COG2319
    Location:212 → 538
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:236 → 273
    7WD40; WD40 repeat [structural motif]

  3. XM_011244662.3 → XP_011242964.1  cell division cycle protein 20 homolog B isoform X5

    UniProtKB/TrEMBL
    M0QWN1
    Conserved Domains (2) summary
    COG2319
    Location:212 → 478
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:236 → 273
    7WD40; WD40 repeat [structural motif]

  4. XM_011244660.3 → XP_011242962.1  cell division cycle protein 20 homolog B isoform X2

    UniProtKB/TrEMBL
    M0QWN1
    Conserved Domains (2) summary
    COG2319
    Location:212 → 495
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:236 → 273
    7WD40; WD40 repeat [structural motif]

  5. XM_011244661.3 → XP_011242963.1  cell division cycle protein 20 homolog B isoform X4

    UniProtKB/TrEMBL
    M0QWN1
    Conserved Domains (2) summary
    COG2319
    Location:212 → 495
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:236 → 273
    7WD40; WD40 repeat [structural motif]

  6. XM_036158047.1 → XP_036013940.1  cell division cycle protein 20 homolog B isoform X6

    UniProtKB/TrEMBL
    M0QWN1
    Conserved Domains (2) summary
    COG2319
    Location:212 → 495
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:236 → 273
    7WD40; WD40 repeat [structural motif]

  7. XM_006517655.4 → XP_006517718.1  cell division cycle protein 20 homolog B isoform X7

    UniProtKB/TrEMBL
    M0QWN1
    Conserved Domains (2) summary
    COG2319
    Location:212 → 495
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:236 → 273
    7WD40; WD40 repeat [structural motif]

  8. XM_006517653.4 → XP_006517716.1  cell division cycle protein 20 homolog B isoform X3

    UniProtKB/TrEMBL
    M0QWN1
    Conserved Domains (2) summary
    COG2319
    Location:230 → 535
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:236 → 273
    7WD40; WD40 repeat [structural motif]

RNA

  1. XR_873755.3 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D3Z3I0.1 GenPept UniProtKB/Swiss-Prot:D3Z3I0

Gene LinkOut

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