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Abcc4 ATP-binding cassette, sub-family C member 4 [ Mus musculus (house mouse) ]

Gene ID: 239273, updated on 28-Oct-2024

Summary

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Official Symbol
Abcc4provided by MGI
Official Full Name
ATP-binding cassette, sub-family C member 4provided by MGI
Primary source
MGI:MGI:2443111
See related
Ensembl:ENSMUSG00000032849 AllianceGenome:MGI:2443111
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MRP4; MOATB; ABCC4-N1; D630049P08Rik
Summary
Predicted to enable several functions, including ABC-type transporter activity; glutathione transmembrane transporter activity; and prostaglandin transmembrane transporter activity. Predicted to be involved in several processes, including cAMP transport; carboxylic acid transport; and urate transport. Predicted to act upstream of or within several processes, including cilium assembly; fatty acid derivative transport; and prostaglandin secretion. Located in apical plasma membrane and basolateral plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human ABCC4 (ATP binding cassette subfamily C member 4 (PEL blood group)). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Broad expression in kidney adult (RPKM 9.2), bladder adult (RPKM 8.4) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Abcc4 in Genome Data Viewer
Location:
14 E4; 14 62.24 cM
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (118720104..118945475, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (118482692..118707856, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32093 Neighboring gene RIKEN cDNA 1700044C05 gene Neighboring gene STARR-seq mESC enhancer starr_37641 Neighboring gene crystallin, zeta pseudogene Neighboring gene STARR-seq mESC enhancer starr_37645 Neighboring gene STARR-seq mESC enhancer starr_37648 Neighboring gene STARR-seq mESC enhancer starr_37651 Neighboring gene predicted gene, 23302 Neighboring gene microRNA 6391 Neighboring gene STARR-seq mESC enhancer starr_37652 Neighboring gene predicted gene, 52104 Neighboring gene STARR-seq mESC enhancer starr_37657 Neighboring gene STARR-seq mESC enhancer starr_37658 Neighboring gene predicted gene, 41247 Neighboring gene STARR-seq mESC enhancer starr_37659 Neighboring gene STARR-seq mESC enhancer starr_37660 Neighboring gene predicted gene 27198 Neighboring gene predicted gene, 46484

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Acquired resistance to acetaminophen hepatotoxicity is associated with induction of multidrug resistance-associated protein 4 (Mrp4) in proliferating hepatocytes. Aleksunes LM, et al. Toxicol Sci, 2008 Aug. PMID 18468992, Free PMC Article
  2. Multi-drug resistance protein 4 (MRP4)-mediated regulation of fibroblast cell migration reflects a dichotomous role of intracellular cyclic nucleotides. Sinha C, et al. J Biol Chem, 2013 Feb 8. PMID 23264633, Free PMC Article
  3. The absence of mrp4 has no effect on the recruitment of neutrophils and eosinophils into the lung after LPS, cigarette smoke or allergen challenge. Schymeinsky J, et al. PLoS One, 2013. PMID 23613808, Free PMC Article
  4. Forskolin modifies retinal vascular development in Mrp4-knockout mice. Matsumiya W, et al. Invest Ophthalmol Vis Sci, 2012 Dec 7. PMID 23154460, Free PMC Article
  5. Deregulated hepatic metabolism exacerbates impaired testosterone production in Mrp4-deficient mice. Morgan JA, et al. J Biol Chem, 2012 Apr 27. PMID 22375007, Free PMC Article

See all (79) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ABCC4 impacts megakaryopoiesis and protects megakaryocytes against 6-mercaptopurine induced cytotoxicity.
    Title: ABCC4 impacts megakaryopoiesis and protects megakaryocytes against 6-mercaptopurine induced cytotoxicity.
  2. ABCC4 is a PGE2 efflux transporter in the ovarian follicle: A mediator of ovulation and a potential non-hormonal contraceptive target.
    Title: ABCC4 is a PGE2 efflux transporter in the ovarian follicle: A mediator of ovulation and a potential non-hormonal contraceptive target.
  3. Role of Membrane Lipid Rafts in MRP4 (ABCC4) Dependent Regulation of the cAMP Pathway in Blood Platelets.
    Title: Role of Membrane Lipid Rafts in MRP4 (ABCC4) Dependent Regulation of the cAMP Pathway in Blood Platelets.
  4. Transporter Activity Changes in Nonalcoholic Steatohepatitis: Assessment with Plasma Coproporphyrin I and III.
    Title: Transporter Activity Changes in Nonalcoholic Steatohepatitis: Assessment with Plasma Coproporphyrin I and III.
  5. An ABC Transporter Drives Medulloblastoma Pathogenesis by Regulating Sonic Hedgehog Signaling.
    Title: An ABC Transporter Drives Medulloblastoma Pathogenesis by Regulating Sonic Hedgehog Signaling.
  6. cyclic AMP efflux via MRP4 plays an essential role in mouse sperm capacitation.
    Title: MRP4-mediated cAMP efflux is essential for mouse spermatozoa capacitation.
  7. TNFalpha induces hepatic MRP4 expression through activation of the p38-E2F1-Nrf2 signaling pathway.
    Title: TNFα Induces Multidrug Resistance-Associated Protein 4 Expression through p38-E2F1-Nrf2 Signaling in Obstructive Cholestasis.
  8. The diversity at N-termini in these protein isoforms explains the diverse function of ABCC4 in mouse.
    Title: A novel exon generates ubiquitously expressed alternatively spliced new transcript of mouse Abcc4 gene.
  9. ABCC4 plays a protective role against cytarabine-mediated insults in leukemic and host myeloid cells.
    Title: ABCC4 Is a Determinant of Cytarabine-Induced Cytotoxicity and Myelosuppression.
  10. P-gp, Bcrp, Mrp1 and Mrp4 are differentially expressed at the outer and inner blood retinal barrier, resulting in an altered ability to limit substrate distribution at the retina as compared with the blood brain barrier
    Title: Blood-brain and retinal barriers show dissimilar ABC transporter impacts and concealed effect of P-glycoprotein on a novel verapamil influx carrier.
Submit: New GeneRIF Correction See all GeneRIFs (40)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ABC-type bile acid transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables ABC-type bile acid transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ABC-type glutathione S-conjugate transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables ABC-type glutathione S-conjugate transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ABC-type xenobiotic transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATPase-coupled transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables ATPase-coupled transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables alcohol transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables efflux transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables efflux transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables glutathione transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables glutathione transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables guanine nucleotide transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables guanine nucleotide transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables prostaglandin transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables prostaglandin transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables purine nucleotide transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables urate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables urate transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables xenobiotic transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables xenobiotic transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in bile acid and bile salt transport ISO
Inferred from Sequence Orthology
more info
  
involved_in bile acid and bile salt transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cAMP transport ISO
Inferred from Sequence Orthology
more info
  
involved_in cAMP transport ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within cilium assembly ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in export across plasma membrane IEA
Inferred from Electronic Annotation
more info
  
involved_in export across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within fatty acid derivative transport ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in glutathione transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in guanine nucleotide transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in leukotriene transport ISO
Inferred from Sequence Orthology
more info
  
involved_in leukotriene transport ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within organic hydroxy compound transport ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within prostaglandin secretion ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in prostaglandin transport ISO
Inferred from Sequence Orthology
more info
  
involved_in prostaglandin transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in urate transport ISO
Inferred from Sequence Orthology
more info
  
involved_in urate transport ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within xenobiotic transmembrane transport TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
NOT located_in cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in external side of apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in platelet dense granule membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ATP-binding cassette sub-family C member 4
Names
ATP-binding cassette, sub-family C (CFTR/MRP), member 4
multidrug resistance-associated protein 4
NP_001028508.2
NP_001157147.1
NP_001157148.1
XP_006519073.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033336.3 → NP_001028508.2  ATP-binding cassette sub-family C member 4 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC154419, AC167668, AK157723, CT025694
    Consensus CDS
    CCDS27335.1
    UniProtKB/Swiss-Prot
    A0A1C9IC75, B7ZWC5, E9Q236, Q3TZN9
    UniProtKB/TrEMBL
    B9EKC2
    Related
    ENSMUSP00000042186.7, ENSMUST00000036554.14
    Conserved Domains (1) summary
    PLN03130
    Location:12 → 1284
    PLN03130; ABC transporter C family member; Provisional

  2. NM_001163675.1 → NP_001157147.1  ATP-binding cassette sub-family C member 4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC154419, AC167668, AK032802, AK052778, AK157723
    UniProtKB/TrEMBL
    B9EKC2
    Related
    ENSMUST00000226703.2
    Conserved Domains (5) summary
    cd03244
    Location:996 → 1215
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:367 → 567
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    TIGR01271
    Location:8 → 1226
    CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
    pfam00664
    Location:675 → 948
    ABC_membrane; ABC transporter transmembrane region
    cl00549
    Location:53 → 322
    ABC_membrane; ABC transporter transmembrane region

  3. NM_001163676.1 → NP_001157148.1  ATP-binding cassette sub-family C member 4 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AC154419, AC167668, CT025694
    Consensus CDS
    CCDS49565.1
    UniProtKB/TrEMBL
    B9EKC2, E9Q467
    Related
    ENSMUSP00000129677.2, ENSMUST00000166646.2
    Conserved Domains (5) summary
    cd03244
    Location:964 → 1183
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:335 → 535
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    TIGR01271
    Location:11 → 1194
    CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
    pfam00664
    Location:643 → 916
    ABC_membrane; ABC transporter transmembrane region
    cl00549
    Location:104 → 290
    ABC_membrane; ABC transporter transmembrane region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    118720104..118945475 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006519010.5 → XP_006519073.1  ATP-binding cassette sub-family C member 4 isoform X1

    Conserved Domains (2) summary
    PLN03130
    Location:12 → 818
    PLN03130; ABC transporter C family member; Provisional
    cd18593
    Location:94 → 386
    ABC_6TM_MRP4_D1_like; Six-transmembrane helical domain 1 (TMD1) of multidrug resistance-associated protein 4 (MRP4) and similar proteins

RNA

  1. XR_004938400.1 RNA Sequence

  2. XR_874344.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E9Q236.1 GenPept UniProtKB/Swiss-Prot:E9Q236

Gene LinkOut

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