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Phf20l1 PHD finger protein 20-like 1 [ Mus musculus (house mouse) ]

Gene ID: 239510, updated on 28-Oct-2024

Summary

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Official Symbol
Phf20l1provided by MGI
Official Full Name
PHD finger protein 20-like 1provided by MGI
Primary source
MGI:MGI:2444412
See related
Ensembl:ENSMUSG00000072501 AllianceGenome:MGI:2444412
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CGI-72; E130113K22Rik
Summary
Predicted to enable methylation-dependent protein binding activity. Predicted to be involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of NSL complex. Is expressed in cortical plate; early conceptus; inner cell mass; and oocyte. Orthologous to human PHF20L1 (PHD finger protein 20 like 1). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Broad expression in CNS E18 (RPKM 6.6), CNS E14 (RPKM 6.2) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Phf20l1 in Genome Data Viewer
Location:
15 D1- D2; 15 29.3 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (66449354..66519821)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (66577500..66647043)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene dynein axonemal assembly factor 11 Neighboring gene STARR-seq mESC enhancer starr_38888 Neighboring gene predicted gene, 31006 Neighboring gene STARR-positive B cell enhancer mm9_chr15:66392494-66392795 Neighboring gene transmembrane protein 71 Neighboring gene STARR-positive B cell enhancer mm9_chr15:66511565-66511866 Neighboring gene thyroglobulin Neighboring gene STARR-positive B cell enhancer mm9_chr15:66616909-66617209 Neighboring gene STARR-positive B cell enhancer ABC_E5484 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:66650248-66650357 Neighboring gene VISTA enhancer mm104 Neighboring gene src-like adaptor Neighboring gene STARR-positive B cell enhancer ABC_E5485 Neighboring gene predicted gene, 46514

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Sf3b4 regulates chromatin remodeler splicing and Hox expression. Kumar S, et al. Differentiation, 2023 May-Jun. PMID 37167859
  2. Jade-1S phosphorylation induced by CK1α contributes to cell cycle progression. Borgal L, et al. Cell Cycle, 2016. PMID 26919559, Free PMC Article
  3. 140 mouse brain proteins identified by Ca2+-calmodulin affinity chromatography and tandem mass spectrometry. Berggård T, et al. J Proteome Res, 2006 Mar. PMID 16512683
  4. Telencephalic embryonic subtractive sequences: a unique collection of neurodevelopmental genes. Bulfone A, et al. J Neurosci, 2005 Aug 17. PMID 16107646, Free PMC Article
  5. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methylation-dependent protein binding IEA
Inferred from Electronic Annotation
more info
  
enables methylation-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of NSL complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
PHD finger protein 20-like protein 1
Names
tudor domain-containing protein PHF20L1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081409.2 → NP_001074878.1  PHD finger protein 20-like protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001074878.1

    Status: VALIDATED

    Source sequence(s)
    AC163443
    Consensus CDS
    CCDS49621.1
    UniProtKB/Swiss-Prot
    A6H5Y9, Q80UN6, Q8BPP8, Q8BQQ6, Q8BS11, Q8C8H9, Q8CCJ9
    Related
    ENSMUSP00000155487.2, ENSMUST00000229160.2
    Conserved Domains (5) summary
    cd04508
    Location:90 → 135
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    PTZ00449
    Location:315 → 506
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cd15633
    Location:683 → 728
    PHD_PHF20L1; PHD finger found in PHD finger protein 20-like protein 1 (P20L1)
    pfam16660
    Location:318 → 383
    PHD20L1_u1; PHD finger protein 20-like protein 1
    cl17705
    Location:3 → 68
    MBT; mbt repeat

  2. NM_001418886.1 → NP_001405815.1  PHD finger protein 20-like protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC163443

  3. NM_001418887.1 → NP_001405816.1  PHD finger protein 20-like protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC163443

  4. NM_001418888.1 → NP_001405817.1  PHD finger protein 20-like protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC163443

  5. NM_001418889.1 → NP_001405818.1  PHD finger protein 20-like protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC163443
    UniProtKB/TrEMBL
    A0A2R8VHV1

  6. NM_001418890.1 → NP_001405819.1  PHD finger protein 20-like protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC163443
    UniProtKB/TrEMBL
    A0A2R8VHV1
    Related
    ENSMUSP00000155465.2, ENSMUST00000230948.2

  7. NM_001418891.1 → NP_001405820.1  PHD finger protein 20-like protein 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC163443

  8. NM_001418892.1 → NP_001405821.1  PHD finger protein 20-like protein 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC163443

  9. NM_001418893.1 → NP_001405822.1  PHD finger protein 20-like protein 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC163443

  10. NM_001418894.1 → NP_001405823.1  PHD finger protein 20-like protein 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC163443

  11. NM_001418896.1 → NP_001405825.1  PHD finger protein 20-like protein 1 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC163443

  12. NM_001418897.1 → NP_001405826.1  PHD finger protein 20-like protein 1 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC163443

  13. NM_001418898.1 → NP_001405827.1  PHD finger protein 20-like protein 1 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC163443

  14. NM_001418899.1 → NP_001405828.1  PHD finger protein 20-like protein 1 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC163443

  15. NM_001418900.1 → NP_001405829.1  PHD finger protein 20-like protein 1 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC163443

  16. NM_001418901.1 → NP_001405830.1  PHD finger protein 20-like protein 1 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC163443
    Related
    ENSMUSP00000155575.2, ENSMUST00000230882.2

  17. NM_001418902.1 → NP_001405831.1  PHD finger protein 20-like protein 1 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC163443

  18. NM_001418903.1 → NP_001405832.1  PHD finger protein 20-like protein 1 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC163443

  19. NM_001418904.1 → NP_001405833.1  PHD finger protein 20-like protein 1 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC163443

  20. NM_001418905.1 → NP_001405834.1  PHD finger protein 20-like protein 1 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC163443

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    66449354..66519821
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520918.4 → XP_006520981.1  PHD finger protein 20-like protein 1 isoform X2

    Conserved Domains (5) summary
    cd04508
    Location:90 → 135
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    PTZ00449
    Location:319 → 510
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cd15633
    Location:687 → 732
    PHD_PHF20L1; PHD finger found in PHD finger protein 20-like protein 1 (P20L1)
    pfam16660
    Location:322 → 387
    PHD20L1_u1; PHD finger protein 20-like protein 1
    cl17705
    Location:3 → 68
    MBT; mbt repeat

  2. XM_030248546.2 → XP_030104406.1  PHD finger protein 20-like protein 1 isoform X5

    Conserved Domains (5) summary
    cd04508
    Location:90 → 135
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    PTZ00449
    Location:290 → 481
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cd15633
    Location:658 → 703
    PHD_PHF20L1; PHD finger found in PHD finger protein 20-like protein 1 (P20L1)
    pfam16660
    Location:293 → 358
    PHD20L1_u1; PHD finger protein 20-like protein 1
    cl17705
    Location:3 → 68
    MBT; mbt repeat

  3. XM_030248545.2 → XP_030104405.1  PHD finger protein 20-like protein 1 isoform X4

    UniProtKB/Swiss-Prot
    A6H5Y9, Q80UN6, Q8BPP8, Q8BQQ6, Q8BS11, Q8C8H9, Q8CCJ9
    Conserved Domains (5) summary
    cd04508
    Location:90 → 135
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    PTZ00449
    Location:315 → 506
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cd15633
    Location:683 → 728
    PHD_PHF20L1; PHD finger found in PHD finger protein 20-like protein 1 (P20L1)
    pfam16660
    Location:318 → 383
    PHD20L1_u1; PHD finger protein 20-like protein 1
    cl17705
    Location:3 → 68
    MBT; mbt repeat

  4. XM_006520919.5 → XP_006520982.1  PHD finger protein 20-like protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A5S8DHC4
    Related
    ENSMUSP00000035682.10, ENSMUST00000048188.10
    Conserved Domains (5) summary
    cd04508
    Location:90 → 135
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    PTZ00449
    Location:316 → 507
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cd15633
    Location:684 → 729
    PHD_PHF20L1; PHD finger found in PHD finger protein 20-like protein 1 (P20L1)
    pfam16660
    Location:319 → 384
    PHD20L1_u1; PHD finger protein 20-like protein 1
    cl17705
    Location:3 → 68
    MBT; mbt repeat

  5. XM_030248548.2 → XP_030104408.1  PHD finger protein 20-like protein 1 isoform X7

    Conserved Domains (1) summary
    cd15633
    Location:262 → 307
    PHD_PHF20L1; PHD finger found in PHD finger protein 20-like protein 1 (P20L1)

  6. XM_006520917.5 → XP_006520980.1  PHD finger protein 20-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006520980.1

    Conserved Domains (5) summary
    cd04508
    Location:90 → 135
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    PTZ00449
    Location:320 → 511
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cd15633
    Location:688 → 733
    PHD_PHF20L1; PHD finger found in PHD finger protein 20-like protein 1 (P20L1)
    pfam16660
    Location:323 → 388
    PHD20L1_u1; PHD finger protein 20-like protein 1
    cl17705
    Location:3 → 68
    MBT; mbt repeat

  7. XM_030248544.2 → XP_030104404.1  PHD finger protein 20-like protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A5S8DHC4
    Conserved Domains (5) summary
    cd04508
    Location:90 → 135
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    PTZ00449
    Location:316 → 507
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cd15633
    Location:684 → 729
    PHD_PHF20L1; PHD finger found in PHD finger protein 20-like protein 1 (P20L1)
    pfam16660
    Location:319 → 384
    PHD20L1_u1; PHD finger protein 20-like protein 1
    cl17705
    Location:3 → 68
    MBT; mbt repeat

  8. XM_036159397.1 → XP_036015290.1  PHD finger protein 20-like protein 1 isoform X7

    Conserved Domains (1) summary
    cd15633
    Location:262 → 307
    PHD_PHF20L1; PHD finger found in PHD finger protein 20-like protein 1 (P20L1)

  9. XM_036159396.1 → XP_036015289.1  PHD finger protein 20-like protein 1 isoform X7

    Conserved Domains (1) summary
    cd15633
    Location:262 → 307
    PHD_PHF20L1; PHD finger found in PHD finger protein 20-like protein 1 (P20L1)

  10. XM_030248547.2 → XP_030104407.1  PHD finger protein 20-like protein 1 isoform X7

    Conserved Domains (1) summary
    cd15633
    Location:262 → 307
    PHD_PHF20L1; PHD finger found in PHD finger protein 20-like protein 1 (P20L1)

  11. XM_030248549.1 → XP_030104409.1  PHD finger protein 20-like protein 1 isoform X7

    Conserved Domains (1) summary
    cd15633
    Location:262 → 307
    PHD_PHF20L1; PHD finger found in PHD finger protein 20-like protein 1 (P20L1)

RNA

  1. XR_003951380.1 RNA Sequence

  2. XR_003951377.1 RNA Sequence

  3. XR_003951385.2 RNA Sequence

  4. XR_003951382.2 RNA Sequence

  5. XR_003951379.2 RNA Sequence

  6. XR_004938835.1 RNA Sequence

  7. XR_003951381.1 RNA Sequence

  8. XR_001781530.3 RNA Sequence

  9. XR_001781529.3 RNA Sequence

  10. XR_003951375.2 RNA Sequence

  11. XR_001781531.3 RNA Sequence

  12. XR_001781528.3 RNA Sequence

  13. XR_001781525.3 RNA Sequence

  14. XR_001781524.3 RNA Sequence

  15. XR_001781526.3 RNA Sequence

  16. XR_003951378.2 RNA Sequence

  17. XR_003951376.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_178718.2: Suppressed sequence

    Description
    NM_178718.2: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CCJ9.2 GenPept UniProtKB/Swiss-Prot:Q8CCJ9

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