U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Nek4 NIMA (never in mitosis gene a)-related expressed kinase 4 [ Mus musculus (house mouse) ]

Gene ID: 23955, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Nek4provided by MGI
Official Full Name
NIMA (never in mitosis gene a)-related expressed kinase 4provided by MGI
Primary source
MGI:MGI:1344404
See related
Ensembl:ENSMUSG00000021918 AllianceGenome:MGI:1344404
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Stk2
Summary
Enables manganese ion binding activity and protein serine/threonine kinase activity. Involved in protein phosphorylation. Located in cytoplasm. Is expressed in seminiferous tubule; spermatid; spermatocyte; and testis. Orthologous to human NEK4 (NIMA related kinase 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 7.7), CNS E11.5 (RPKM 2.9) and 24 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Nek4 in Genome Data Viewer
Location:
14 B; 14 19.09 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (30673334..30710778)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (30951377..30988821)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene inter-alpha trypsin inhibitor, heavy chain 1 Neighboring gene STARR-positive B cell enhancer ABC_E3106 Neighboring gene predicted gene, 41121 Neighboring gene STARR-seq mESC enhancer starr_36312 Neighboring gene signal peptidase complex subunit 1 homolog (S. cerevisiae) Neighboring gene glycosyltransferase 8 domain containing 1 Neighboring gene small nucleolar RNA, C/D box 69 Neighboring gene guanine nucleotide binding protein nucleolar 3

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. NEK4 modulates circadian fluctuations of emotional behaviors and synaptogenesis in male mice. Yang ZH, et al. Nat Commun, 2024 Oct 24. PMID 39448584, Free PMC Article
  2. Nek4 status differentially alters sensitivity to distinct microtubule poisons. Doles J, et al. Cancer Res, 2010 Feb 1. PMID 20103636, Free PMC Article
  3. Activity and substrate specificity of the murine STK2 Serine/Threonine kinase that is structurally related to the mitotic regulator protein NIMA of Aspergillus nidulans. Hayashi K, et al. Biochem Biophys Res Commun, 1999 Oct 22. PMID 10529384
  4. Exploration of the cell-cycle genes found within the RIKEN FANTOM2 data set. Forrest AR, et al. Genome Res, 2003 Jun. PMID 12819135, Free PMC Article
  5. NIMA-related kinases: isolation and characterization of murine nek3 and nek4 cDNAs, and chromosomal localization of nek1, nek2 and nek3. Chen A, et al. Gene, 1999 Jun 24. PMID 10393247

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NEK4 modulates circadian fluctuations of emotional behaviors and synaptogenesis in male mice.
    Title: NEK4 modulates circadian fluctuations of emotional behaviors and synaptogenesis in male mice.
  2. Data show that after Taxol treatment, Nek4 promoted microtubule outgrowth, whereas Nek4 deficiency impaired G(2)-M arrest and decreased formation of mitotic-like asters.
    Title: Nek4 status differentially alters sensitivity to distinct microtubule poisons.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables manganese ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA damage response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cellular senescence ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cellular senescence ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary plasm ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary rootlet ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary transition zone ISO
Inferred from Sequence Orthology
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
serine/threonine-protein kinase Nek4
Names
serine/threonine-protein kinase 2
NP_001295257.1
NP_035979.1
XP_011243370.1
XP_011243371.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308328.1 → NP_001295257.1  serine/threonine-protein kinase Nek4 isoform 2

    See identical proteins and their annotated locations for NP_001295257.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK078809, AK149584, BP762751
    Consensus CDS
    CCDS88612.1
    UniProtKB/Swiss-Prot
    O35673, Q9R1J1, Q9Z1J2
    UniProtKB/TrEMBL
    Q3UED6
    Related
    ENSMUSP00000154678.2, ENSMUST00000226551.2
    Conserved Domains (2) summary
    smart00220
    Location:6 → 261
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08223
    Location:5 → 261
    STKc_Nek4; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 4

  2. NM_011849.3 → NP_035979.1  serine/threonine-protein kinase Nek4 isoform 1

    See identical proteins and their annotated locations for NP_035979.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK078809, AK149584, BP762751, CN526970
    Consensus CDS
    CCDS26902.1
    UniProtKB/Swiss-Prot
    O35673, Q9R1J1, Q9Z1J2
    UniProtKB/TrEMBL
    Q6GTE9
    Related
    ENSMUSP00000154090.2, ENSMUST00000228328.2
    Conserved Domains (2) summary
    smart00220
    Location:6 → 261
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08223
    Location:5 → 261
    STKc_Nek4; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 4

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    30673334..30710778
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011245069.4 → XP_011243371.1  serine/threonine-protein kinase Nek4 isoform X2

    UniProtKB/Swiss-Prot
    O35673, Q9R1J1, Q9Z1J2
    Related
    ENSMUSP00000153710.2, ENSMUST00000226146.2
    Conserved Domains (1) summary
    cl21453
    Location:1 → 179
    PKc_like; Protein Kinases, catalytic domain

  2. XM_011245068.4 → XP_011243370.1  serine/threonine-protein kinase Nek4 isoform X1

    UniProtKB/TrEMBL
    F8WGA9
    Conserved Domains (1) summary
    cl21453
    Location:25 → 254
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z1J2.1 GenPept UniProtKB/Swiss-Prot:Q9Z1J2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools