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Ttll8 tubulin tyrosine ligase-like family, member 8 [ Mus musculus (house mouse) ]

Gene ID: 239591, updated on 2-Nov-2024

Summary

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Official Symbol
Ttll8provided by MGI
Official Full Name
tubulin tyrosine ligase-like family, member 8provided by MGI
Primary source
MGI:MGI:1922902
See related
Ensembl:ENSMUSG00000022388 AllianceGenome:MGI:1922902
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4933401B17; 1700019P01Rik
Summary
Enables protein-glycine ligase activity, initiating. Involved in flagellated sperm motility and protein polyglycylation. Acts upstream of or within cilium assembly. Located in axoneme; microtubule cytoskeleton; and sperm flagellum. Orthologous to human TTLL8 (tubulin tyrosine ligase like 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward testis adult (RPKM 37.7) See more
Orthologs
human all
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Genomic context

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See Ttll8 in Genome Data Viewer
Location:
15 E3; 15 44.39 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (88773981..88839258, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (88889778..88955051, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 23144 Neighboring gene STARR-positive B cell enhancer ABC_E4145 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:88692779-88692962 Neighboring gene predicted gene, 33049 Neighboring gene STARR-seq mESC enhancer starr_39448 Neighboring gene proviral integration site 3 Neighboring gene predicted gene, 38643 Neighboring gene STARR-seq mESC enhancer starr_39454 Neighboring gene megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human) Neighboring gene proteasome maturation protein pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Tubulin glycylation controls axonemal dynein activity, flagellar beat, and male fertility. Gadadhar S, et al. Science, 2021 Jan 8. PMID 33414192, Free PMC Article
  2. Tubulin glycylases are required for primary cilia, control of cell proliferation and tumor development in colon. Rocha C, et al. EMBO J, 2014 Oct 1. PMID 25180231, Free PMC Article
  3. TTLL10 can perform tubulin glycylation when co-expressed with TTLL8. Ikegami K, et al. FEBS Lett, 2009 Jun 18. PMID 19427864
  4. Crystal structure of tubulin tyrosine ligase-like 3 reveals essential architectural elements unique to tubulin monoglycylases. Garnham CP, et al. Proc Natl Acad Sci U S A, 2017 Jun 20. PMID 28576883, Free PMC Article
  5. Tubulin glycylases and glutamylases have distinct functions in stabilization and motility of ependymal cilia. Bosch Grau M, et al. J Cell Biol, 2013 Aug 5. PMID 23897886, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (5)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-glycine ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-glycine ligase activity, initiating IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-glycine ligase activity, initiating IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-glycine ligase activity, initiating IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in axoneme assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cilium assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in flagellated sperm motility IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in flagellated sperm motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein polyglycylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein polyglycylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in axoneme IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in axoneme IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in sperm flagellum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sperm flagellum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protein monoglycylase TTLL8
Names
TTL domain protein
tubulin--tyrosine ligase-like protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357736.2 → NP_001344665.1  protein monoglycylase TTLL8 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC119959
    Conserved Domains (1) summary
    pfam03133
    Location:193 → 415
    TTL; Tubulin-tyrosine ligase family

  2. NM_001428803.1 → NP_001415732.1  protein monoglycylase TTLL8 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC117700, AC119959

  3. NM_001428811.1 → NP_001415740.1  protein monoglycylase TTLL8 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC117700, AC119959

  4. NM_172818.4 → NP_766406.3  protein monoglycylase TTLL8 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC119959
    Consensus CDS
    CCDS27735.2
    Related
    ENSMUSP00000104996.2, ENSMUST00000109371.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    88773981..88839258 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159403.1 → XP_036015296.1  protein monoglycylase TTLL8 isoform X3

  2. XM_011245621.3 → XP_011243923.1  protein monoglycylase TTLL8 isoform X2

    UniProtKB/Swiss-Prot
    A4Q9F1, Q14B76, Q8C0N7
    Conserved Domains (1) summary
    pfam03133
    Location:487 → 709
    TTL; Tubulin-tyrosine ligase family

  3. XM_006520959.5 → XP_006521022.1  protein monoglycylase TTLL8 isoform X4

    See identical proteins and their annotated locations for XP_006521022.1

    UniProtKB/TrEMBL
    Q8C0V2
    Conserved Domains (1) summary
    pfam03133
    Location:193 → 415
    TTL; Tubulin-tyrosine ligase family

  4. XM_006520955.4 → XP_006521018.1  protein monoglycylase TTLL8 isoform X1

    UniProtKB/Swiss-Prot
    A4Q9F1, Q14B76, Q8C0N7
    Conserved Domains (1) summary
    pfam03133
    Location:487 → 709
    TTL; Tubulin-tyrosine ligase family

  5. XM_011245623.4 → XP_011243925.1  protein monoglycylase TTLL8 isoform X6

  6. XM_011245622.4 → XP_011243924.1  protein monoglycylase TTLL8 isoform X5

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A4Q9F1.1 GenPept UniProtKB/Swiss-Prot:A4Q9F1

Gene LinkOut

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