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Oasl2 2'-5' oligoadenylate synthetase-like 2 [ Mus musculus (house mouse) ]

Gene ID: 23962, updated on 2-Nov-2024

Summary

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Official Symbol
Oasl2provided by MGI
Official Full Name
2'-5' oligoadenylate synthetase-like 2provided by MGI
Primary source
MGI:MGI:1344390
See related
Ensembl:ENSMUSG00000029561 AllianceGenome:MGI:1344390
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Oasl; M1204; Mmu-OASL
Summary
Enables 2'-5'-oligoadenylate synthetase activity and double-stranded RNA binding activity. Involved in interleukin-27-mediated signaling pathway and purine nucleotide biosynthetic process. Predicted to be active in cytosol; membrane; and nucleoplasm. Is expressed in central nervous system; retina; right atrium; and thymus primordium. Orthologous to human OASL2P (2'-5' oligoadenylate synthetase like 2, pseudogene). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in large intestine adult (RPKM 7.4), bladder adult (RPKM 5.9) and 25 other tissues See more
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Genomic context

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See Oasl2 in Genome Data Viewer
Location:
5 F; 5 55.99 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (115034995..115050306)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (114896926..114912245)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930519G04 gene Neighboring gene microRNA 6240 Neighboring gene predicted gene 9936 Neighboring gene STARR-positive B cell enhancer ABC_E6367 Neighboring gene STARR-seq mESC enhancer starr_14091 Neighboring gene predicted gene 13822 Neighboring gene 2'-5' oligoadenylate synthetase-like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. M1204, a novel 2',5' oligoadenylate synthetase with a ubiquitin-like extension, is induced during maturation of murine dendritic cells. Tiefenthaler M, et al. J Immunol, 1999 Jul 15. PMID 10395668
  2. Oligoadenylate-Synthetase-Family Protein OASL Inhibits Activity of the DNA Sensor cGAS during DNA Virus Infection to Limit Interferon Production. Ghosh A, et al. Immunity, 2019 Jan 15. PMID 30635239, Free PMC Article
  3. Antiviral activity of human OASL protein is mediated by enhancing signaling of the RIG-I RNA sensor. Zhu J, et al. Immunity, 2014 Jun 19. PMID 24931123, Free PMC Article
  4. Expansion and molecular evolution of the interferon-induced 2'-5' oligoadenylate synthetase gene family. Kumar S, et al. Mol Biol Evol, 2000 May. PMID 10779534
  5. Development of IFN-Stimulated Gene Expression from Embryogenesis through Adulthood, with and without Constitutive MDA5 Pathway Activation. Bankers L, et al. J Immunol, 2020 May 15. PMID 32277054, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. these resulta define distinct mechanisms by which OASL differentially regulates host IFN responses during RNA and DNA virus infection and identify OASL as a negative-feedback regulator of cGAS
    Title: Oligoadenylate-Synthetase-Family Protein OASL Inhibits Activity of the DNA Sensor cGAS during DNA Virus Infection to Limit Interferon Production.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 2'-5'-oligoadenylate synthetase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 2'-5'-oligoadenylate synthetase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables double-stranded RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in antiviral innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response to virus IEA
Inferred from Electronic Annotation
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in interleukin-27-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in interleukin-27-mediated signaling pathway IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in negative regulation of viral genome replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in purine nucleotide biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to virus TAS
Traceable Author Statement
more info
 PubMed 
involved_in type I interferon-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
2'-5'-oligoadenylate synthase-like protein 2
Names
54 kDa 2'-5'-oligoadenylate synthase-like protein 2
54 kDa 2'-5'-oligoadenylate synthetase-like protein 2
p54 OASL
NP_001346110.1
NP_035984.2
XP_006530377.1
XP_006530378.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359181.1 → NP_001346110.1  2'-5'-oligoadenylate synthase-like protein 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC117799, AK160630
    UniProtKB/TrEMBL
    F6VMV6
    Conserved Domains (3) summary
    cd01811
    Location:107 → 186
    OASL_repeat1; 2'-5' oligoadenylate synthetase-like protein, repeat 1 of 2
    pfam10421
    Location:1 → 104
    OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
    cl25424
    Location:189 → 255
    TGS; The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information ...

  2. NM_011854.2 → NP_035984.2  2'-5'-oligoadenylate synthase-like protein 2 isoform 1

    See identical proteins and their annotated locations for NP_035984.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC116500, AK010034, BY426738
    Consensus CDS
    CCDS39226.1
    UniProtKB/Swiss-Prot
    Q9D6S2, Q9Z2F2
    UniProtKB/TrEMBL
    Q8K234
    Related
    ENSMUSP00000031542.10, ENSMUST00000031542.13
    Conserved Domains (4) summary
    cd05400
    Location:29 → 214
    NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
    cd01811
    Location:355 → 428
    Ubl1_OASL; ubiquitin-like (Ubl) domain 1 found in 2'-5'-oligoadenylate synthase-like protein (OASL) and similar proteins
    pfam10421
    Location:170 → 352
    OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
    cl28922
    Location:434 → 505
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    115034995..115050306
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530315.5 → XP_006530378.1  2'-5'-oligoadenylate synthase-like protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006530378.1

    UniProtKB/Swiss-Prot
    Q9D6S2, Q9Z2F2
    UniProtKB/TrEMBL
    Q8K234
    Conserved Domains (4) summary
    cd05400
    Location:29 → 214
    NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
    cd01811
    Location:355 → 428
    Ubl1_OASL; ubiquitin-like (Ubl) domain 1 found in 2'-5'-oligoadenylate synthase-like protein (OASL) and similar proteins
    pfam10421
    Location:170 → 352
    OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
    cl28922
    Location:434 → 505
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  2. XM_006530314.5 → XP_006530377.1  2'-5'-oligoadenylate synthase-like protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006530377.1

    UniProtKB/Swiss-Prot
    Q9D6S2, Q9Z2F2
    UniProtKB/TrEMBL
    Q8K234
    Conserved Domains (4) summary
    cd05400
    Location:29 → 214
    NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
    cd01811
    Location:355 → 428
    Ubl1_OASL; ubiquitin-like (Ubl) domain 1 found in 2'-5'-oligoadenylate synthase-like protein (OASL) and similar proteins
    pfam10421
    Location:170 → 352
    OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
    cl28922
    Location:434 → 505
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z2F2.2 GenPept UniProtKB/Swiss-Prot:Q9Z2F2

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