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Mrtfb myocardin related transcription factor B [ Mus musculus (house mouse) ]

Gene ID: 239719, updated on 28-Oct-2024

Summary

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Official Symbol
Mrtfbprovided by MGI
Official Full Name
myocardin related transcription factor Bprovided by MGI
Primary source
MGI:MGI:3050795
See related
Ensembl:ENSMUSG00000009569 AllianceGenome:MGI:3050795
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mkl2; Gt4-1; MRTF-B; SOLOIST; mKIAA1243
Summary
Enables DNA-binding transcription factor activity; actin binding activity; and transcription coactivator activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including circulatory system development; liver development; and nervous system development. Located in cytoplasm. Is expressed in several structures, including cardiovascular system; central nervous system; genitourinary system; intestine wall; and lung. Orthologous to human MRTFB (myocardin related transcription factor B). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in frontal lobe adult (RPKM 9.3), cortex adult (RPKM 9.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Mrtfb in Genome Data Viewer
Location:
16 A1; 16 9.24 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (13073913..13235393)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (13256056..13417529)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr16:13109553-13109853 Neighboring gene STARR-seq mESC enhancer starr_40135 Neighboring gene excision repair cross-complementing rodent repair deficiency, complementation group 4 Neighboring gene predicted gene, 32596 Neighboring gene STARR-seq mESC enhancer starr_40139 Neighboring gene STARR-seq mESC enhancer starr_40140 Neighboring gene uncharacterized LOC115488652 Neighboring gene predicted gene 15738 Neighboring gene nuclear encoded tRNA threonine 5 (anticodon CGT) Neighboring gene predicted gene, 41421 Neighboring gene predicted gene 53058 Neighboring gene predicted gene, 32817 Neighboring gene microRNA 193b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression of SOLOIST/MRTFB i4, a novel neuronal isoform of the mouse serum response factor coactivator myocardin-related transcription factor-B, negatively regulates dendritic complexity in cortical neurons. Ishibashi Y, et al. J Neurochem, 2021 Nov. PMID 32639614
  2. Dynamic subcellular localization and transcription activity of the SRF cofactor MKL2 in the striatum are regulated by MAPK. Ariza A, et al. J Neurochem, 2021 Jun. PMID 33449379
  3. Myocardin-related transcription factors are required for skeletal muscle development. Cenik BK, et al. Development, 2016 Aug 1. PMID 27385017, Free PMC Article
  4. Myocardin-related transcription factors are required for cardiac development and function. Mokalled MH, et al. Dev Biol, 2015 Oct 15. PMID 26386146, Free PMC Article
  5. Exercise-dependent increases in protein synthesis are accompanied by chromatin modifications and increased MRTF-SRF signalling. Solagna F, et al. Acta Physiol (Oxf), 2020 Sep. PMID 32408395, Free PMC Article

See all (70) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. KLF15 maintains contractile phenotype of vascular smooth muscle cells and prevents thoracic aortic dissection by interacting with MRTFB.
    Title: KLF15 maintains contractile phenotype of vascular smooth muscle cells and prevents thoracic aortic dissection by interacting with MRTFB.
  2. The actin-binding protein CAP1 represses MRTF-SRF-dependent gene expression in mouse cerebral cortex.
    Title: The actin-binding protein CAP1 represses MRTF-SRF-dependent gene expression in mouse cerebral cortex.
  3. Expression of SOLOIST/MRTFB i4, a novel neuronal isoform of the mouse serum response factor coactivator myocardin-related transcription factor-B, negatively regulates dendritic complexity in cortical neurons.
    Title: Expression of SOLOIST/MRTFB i4, a novel neuronal isoform of the mouse serum response factor coactivator myocardin-related transcription factor-B, negatively regulates dendritic complexity in cortical neurons.
  4. Dynamic subcellular localization and transcription activity of the SRF cofactor MKL2 in the striatum are regulated by MAPK.
    Title: Dynamic subcellular localization and transcription activity of the SRF cofactor MKL2 in the striatum are regulated by MAPK.
  5. Exercise-dependent increases in protein synthesis are accompanied by chromatin modifications and increased MRTF-SRF signalling.
    Title: Exercise-dependent increases in protein synthesis are accompanied by chromatin modifications and increased MRTF-SRF signalling.
  6. Knockout of Mrtfb in mouse intestine significantly enhances tumor development in Apc mutant mice.
    Title: MRTFB suppresses colorectal cancer development through regulating SPDL1 and MCAM.
  7. MRTF-A/B control an acute mechanosensitive signaling circuit that coordinates cross-talk between the actin and microtubule cytoskeleton and maintains intercalated disc integrity and cardiomyocyte homeostasis in heart disease.
    Title: Mechanosensitive Gene Regulation by Myocardin-Related Transcription Factors Is Required for Cardiomyocyte Integrity in Load-Induced Ventricular Hypertrophy.
  8. In conclusion, SRF andMKL1/MKL2 are essential for postnatal podocyte structure and function, likely through the maintenance of a normal actin cytoskeleton.
    Title: Serum Response Factor Is Essential for Maintenance of Podocyte Structure and Function.
  9. BRG1 promotes transcription of endothelial Mrtfa and Mrtfb, which elevates expression of SRF and SRF target genes that establish embryonic capillary integrity.
    Title: BRG1 (Brahma-Related Gene 1) Promotes Endothelial Mrtf Transcription to Establish Embryonic Capillary Integrity.
  10. MRTF-A/B depletion results in an increase in the cell surface expression of ICAM-1 and interactions between HAoECs and leukocytes
    Title: A novel inhibitory mechanism of MRTF-A/B on the ICAM-1 gene expression in vascular endothelial cells.
Submit: New GeneRIF Correction See all GeneRIFs (29)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1243, MGC41582

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables actin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within actin cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within blood vessel morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cardiac muscle tissue development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within embryonic organ development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within forebrain development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within liver development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in muscle organ development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neuron migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within neuron projection development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of miRNA transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of striated muscle tissue development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of striated muscle tissue development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in smooth muscle cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within vascular associated smooth muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IC
Inferred by Curator
more info
 PubMed 

General protein information

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Preferred Names
myocardin-related transcription factor B
Names
MKL/myocardin-like 2
MKL/myocardin-like protein 2
gene trap insertion site 4-1
megakaryoblastic leukemia 2
myocardial related transcription factor B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122667.2 → NP_001116139.1  myocardin-related transcription factor B isoform 3

    See identical proteins and their annotated locations for NP_001116139.1

    Status: VALIDATED

    Source sequence(s)
    AC160961, AC163640
    Consensus CDS
    CCDS49768.1
    UniProtKB/TrEMBL
    A3KMF2, G3X8R8
    Related
    ENSMUSP00000009713.8, ENSMUST00000009713.14
    Conserved Domains (5) summary
    PHA03247
    Location:197 → 321
    PHA03247; large tegument protein UL36; Provisional
    pfam02037
    Location:394 → 427
    SAP; SAP domain
    pfam02755
    Location:141 → 163
    RPEL; RPEL repeat
    cl20817
    Location:565 → 605
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl29414
    Location:52 → 76
    RPEL; RPEL repeat

  2. NM_153588.3 → NP_705816.2  myocardin-related transcription factor B isoform 1

    See identical proteins and their annotated locations for NP_705816.2

    Status: VALIDATED

    Source sequence(s)
    AC163640, AF532598, CJ126058, CK639342
    Consensus CDS
    CCDS37258.1
    UniProtKB/Swiss-Prot
    P59759
    UniProtKB/TrEMBL
    Q5DTZ3
    Related
    ENSMUSP00000122815.2, ENSMUST00000149359.2
    Conserved Domains (4) summary
    smart00707
    Location:128 → 153
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02037
    Location:383 → 416
    SAP; SAP domain
    pfam02755
    Location:86 → 107
    RPEL; RPEL repeat
    pfam09903
    Location:551 → 588
    DUF2130; Uncharacterized protein conserved in bacteria (DUF2130)

  3. NM_181860.1 → NP_862908.1  myocardin-related transcription factor B isoform 2

    See identical proteins and their annotated locations for NP_862908.1

    Status: VALIDATED

    Source sequence(s)
    BC028459
    Consensus CDS
    CCDS37257.1
    UniProtKB/TrEMBL
    Q8R2L3
    Related
    ENSMUSP00000054993.7, ENSMUST00000056715.7

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    13073913..13235393
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522109.5 → XP_006522172.1  myocardin-related transcription factor B isoform X1

    See identical proteins and their annotated locations for XP_006522172.1

    UniProtKB/TrEMBL
    A0A8D4USI8, A3KMF2
    Conserved Domains (5) summary
    PHA03247
    Location:218 → 342
    PHA03247; large tegument protein UL36; Provisional
    pfam02037
    Location:415 → 448
    SAP; SAP domain
    pfam02755
    Location:162 → 184
    RPEL; RPEL repeat
    cl20817
    Location:586 → 626
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl29414
    Location:73 → 97
    RPEL; RPEL repeat

  2. XM_030249105.2 → XP_030104965.1  myocardin-related transcription factor B isoform X2

    UniProtKB/TrEMBL
    A3KMF2, G3X8R8
    Conserved Domains (5) summary
    PHA03247
    Location:197 → 321
    PHA03247; large tegument protein UL36; Provisional
    pfam02037
    Location:394 → 427
    SAP; SAP domain
    pfam02755
    Location:141 → 163
    RPEL; RPEL repeat
    cl20817
    Location:565 → 605
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl29414
    Location:52 → 76
    RPEL; RPEL repeat

  3. XM_006522108.4 → XP_006522171.1  myocardin-related transcription factor B isoform X1

    See identical proteins and their annotated locations for XP_006522171.1

    UniProtKB/TrEMBL
    A0A8D4USI8, A3KMF2
    Conserved Domains (5) summary
    PHA03247
    Location:218 → 342
    PHA03247; large tegument protein UL36; Provisional
    pfam02037
    Location:415 → 448
    SAP; SAP domain
    pfam02755
    Location:162 → 184
    RPEL; RPEL repeat
    cl20817
    Location:586 → 626
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl29414
    Location:73 → 97
    RPEL; RPEL repeat

  4. XM_006522111.3 → XP_006522174.1  myocardin-related transcription factor B isoform X3

    See identical proteins and their annotated locations for XP_006522174.1

    UniProtKB/TrEMBL
    Q8R2L3
    Related
    ENSMUSP00000111476.2, ENSMUST00000115809.8

  5. XM_030249106.2 → XP_030104966.1  myocardin-related transcription factor B isoform X2

    UniProtKB/TrEMBL
    A3KMF2, G3X8R8
    Conserved Domains (5) summary
    PHA03247
    Location:197 → 321
    PHA03247; large tegument protein UL36; Provisional
    pfam02037
    Location:394 → 427
    SAP; SAP domain
    pfam02755
    Location:141 → 163
    RPEL; RPEL repeat
    cl20817
    Location:565 → 605
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl29414
    Location:52 → 76
    RPEL; RPEL repeat

  6. XM_036159917.1 → XP_036015810.1  myocardin-related transcription factor B isoform X1

    UniProtKB/TrEMBL
    A0A8D4USI8, A3KMF2
    Conserved Domains (5) summary
    PHA03247
    Location:218 → 342
    PHA03247; large tegument protein UL36; Provisional
    pfam02037
    Location:415 → 448
    SAP; SAP domain
    pfam02755
    Location:162 → 184
    RPEL; RPEL repeat
    cl20817
    Location:586 → 626
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl29414
    Location:73 → 97
    RPEL; RPEL repeat

  7. XM_030249104.2 → XP_030104964.1  myocardin-related transcription factor B isoform X1

    UniProtKB/TrEMBL
    A0A8D4USI8, A3KMF2
    Conserved Domains (5) summary
    PHA03247
    Location:218 → 342
    PHA03247; large tegument protein UL36; Provisional
    pfam02037
    Location:415 → 448
    SAP; SAP domain
    pfam02755
    Location:162 → 184
    RPEL; RPEL repeat
    cl20817
    Location:586 → 626
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl29414
    Location:73 → 97
    RPEL; RPEL repeat
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P59759.1 GenPept UniProtKB/Swiss-Prot:P59759

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