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Rimbp3 RIMS binding protein 3 [ Mus musculus (house mouse) ]

Gene ID: 239731, updated on 2-Nov-2024

Summary

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Official Symbol
Rimbp3provided by MGI
Official Full Name
RIMS binding protein 3provided by MGI
Primary source
MGI:MGI:2685449
See related
Ensembl:ENSMUSG00000071636 AllianceGenome:MGI:2685449
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm603; Gm1759; RIM-BP3; mKIAA1666
Summary
Predicted to enable benzodiazepine receptor binding activity. Involved in fertilization and spermatid development. Located in nucleus. Colocalizes with manchette. Orthologous to human RIMBP3 (RIMS binding protein 3); RIMBP3B (RIMS binding protein 3B); and RIMBP3C (RIMS binding protein 3C). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See Rimbp3 in Genome Data Viewer
Location:
16 A3; 16 10.67 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (17025999..17031846)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (17208135..17213982)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2L 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:17201546-17201655 Neighboring gene predicted gene, 22129 Neighboring gene STARR-seq mESC enhancer starr_40246 Neighboring gene STARR-positive B cell enhancer ABC_E7430 Neighboring gene hypermethylated in cancer 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:17276268-17276485 Neighboring gene transmembrane protein 191

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. RIM-BP3 is a manchette-associated protein essential for spermiogenesis. Zhou J, et al. Development, 2009 Feb. PMID 19091768
  2. Structure and evolution of RIM-BP genes: identification of a novel family member. Mittelstaedt T, et al. Gene, 2007 Nov 15. PMID 17855024
  3. Integrative characterization of germ cell-specific genes from mouse spermatocyte UniGene library. Choi E, et al. BMC Genomics, 2007 Jul 28. PMID 17662146, Free PMC Article
  4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables benzodiazepine receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in fertilization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fertilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT involved_in neuromuscular synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermatid development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermatid development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with manchette IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with manchette IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
RIMS-binding protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033338.3 → NP_001028510.2  RIMS-binding protein 3

    Status: VALIDATED

    Source sequence(s)
    AA030140, AC154667, AK133200, BG075083
    Consensus CDS
    CCDS27998.2
    UniProtKB/Swiss-Prot
    B9EJ89, E9PZY2, Q3V0F0, Q5DTW0
    Related
    ENSMUSP00000127909.2, ENSMUST00000169803.5
    Conserved Domains (3) summary
    smart00060
    Location:982 → 1043
    FN3; Fibronectin type 3 domain
    TIGR02168
    Location:29 → 671
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cl17036
    Location:826 → 886
    SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    17025999..17031846
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3V0F0.2 GenPept UniProtKB/Swiss-Prot:Q3V0F0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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