Klhl6 kelch-like 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Klhl6provided by MGI
Official Full Name: kelch-like 6provided by MGI
Primary source: MGI:MGI:2686922
See related: Ensembl:ENSMUSG00000043008 AllianceGenome:MGI:2686922
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Involved in B cell receptor signaling pathway and germinal center formation. Acts upstream of or within response to bacterium. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in blood vessel; notochord; and thymus primordium. Orthologous to human KLHL6 (kelch like family member 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in thymus adult (RPKM 18.2), spleen adult (RPKM 14.8) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 A3; 16 12.32 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (19765242..19801766, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (19946492..19983049, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

report that KLHL6, which is recurrently mutated in B cell lymphomas, is an off-target of the normal somatic hypermutation process taking place in germinal center (GC) B cells leaving open whether, despite the lack of impact of Klhl6 deficiency on GC B cell expansion, mutants could contribute to the oncogenic process
Title: Klhl6 Deficiency Impairs Transitional B Cell Survival and Differentiation.
related to islet dysfunction during the development of type 2 diabetes
Title: An Islet-Targeted Genome-Wide Association Scan Identifies Novel Genes Implicated in Cytokine-Mediated Islet Stress in Type 2 Diabetes.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (9)
Endonuclease-mediated (2)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ubiquitin-like ligase-substrate adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in B cell receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germinal center formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
part_of Cul3-RING ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: kelch-like protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001417212.1 → NP_001404141.1 kelch-like protein 6 isoform 2

Status: VALIDATED

Source sequence(s)

AC165282
NM_001417213.1 → NP_001404142.1 kelch-like protein 6 isoform 3

Status: VALIDATED

Source sequence(s)

AC165282
NM_001417214.1 → NP_001404143.1 kelch-like protein 6 isoform 4

Status: VALIDATED

Source sequence(s)

AC165282
NM_001417215.1 → NP_001404144.1 kelch-like protein 6 isoform 5

Status: VALIDATED

Source sequence(s)

AC165282
NM_001417216.1 → NP_001404145.1 kelch-like protein 6 isoform 6

Status: VALIDATED

Source sequence(s)

AC165282
NM_183390.4 → NP_899246.2 kelch-like protein 6 isoform 1

See identical proteins and their annotated locations for NP_899246.2

Status: VALIDATED

Source sequence(s)

AC165282

Consensus CDS

CCDS28041.2

UniProtKB/Swiss-Prot

Q497G3, Q6V595

Related

ENSMUSP00000053023.9, ENSMUST00000058839.10

Conserved Domains (6) summary

smart00612
Location:420 → 466

Kelch; Kelch domain

smart00225
Location:71 → 163

BTB; Broad-Complex, Tramtrack and Bric a brac

sd00038
Location:368 → 405

Kelch; KELCH repeat [structural motif]

pfam00651
Location:60 → 163

BTB; BTB/POZ domain

pfam01344
Location:457 → 501

Kelch_1; Kelch motif

pfam07707
Location:172 → 274

BACK; BTB And C-terminal Kelch

RNA

NR_184432.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC165282

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

19765242..19801766 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036159920.1 → XP_036015813.1 kelch-like protein 6 isoform X2

Conserved Domains (5) summary

PHA03098
Location:11 → 487

PHA03098; kelch-like protein; Provisional

sd00038
Location:292 → 329

Kelch; KELCH repeat [structural motif]

cl38908
Location:20 → 98

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

pfam01344
Location:470 → 507

Kelch_1; Kelch motif

cl28903
Location:91 → 198

BACK; BACK (BTB and C-terminal Kelch) domain