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Pigz phosphatidylinositol glycan anchor biosynthesis, class Z [ Mus musculus (house mouse) ]

Gene ID: 239827, updated on 2-Nov-2024

Summary

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Official Symbol
Pigzprovided by MGI
Official Full Name
phosphatidylinositol glycan anchor biosynthesis, class Zprovided by MGI
Primary source
MGI:MGI:2443822
See related
Ensembl:ENSMUSG00000045625 AllianceGenome:MGI:2443822
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
F630022B06Rik
Summary
Predicted to enable alpha-1,2-mannosyltransferase activity. Predicted to be involved in GPI anchor biosynthetic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human PIGZ (phosphatidylinositol glycan anchor biosynthesis class Z). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in cerebellum adult (RPKM 2.0), cortex adult (RPKM 1.4) and 22 other tissues See more
Orthologs
human all
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Genomic context

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See Pigz in Genome Data Viewer
Location:
16 B2; 16 22.4 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (31745797..31764866)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (31926965..31946048)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34476 Neighboring gene ribonuclease H2, large subunit pseudogene Neighboring gene Ncbp2 antisense 2 (head to head) Neighboring gene nuclear cap binding protein subunit 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Behavioral changes and growth deficits in a CRISPR engineered mouse model of the schizophrenia-associated 3q29 deletion. Rutkowski TP, et al. Mol Psychiatry, 2021 Mar. PMID 30976085, Free PMC Article
  2. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alpha-1,2-mannosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-1,2-mannosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables mannosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in GPI anchor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in GPI anchor biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
GPI mannosyltransferase 4
Names
GPI mannosyltransferase IV
GPI-MT-IV
PIG-Z
phosphatidylinositol glycan, class Z
phosphatidylinositol-glycan biosynthesis class Z protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172822.3 → NP_766410.2  GPI mannosyltransferase 4

    See identical proteins and their annotated locations for NP_766410.2

    Status: VALIDATED

    Source sequence(s)
    AC124681
    Consensus CDS
    CCDS28109.1
    UniProtKB/Swiss-Prot
    Q149K0, Q8BTP0
    Related
    ENSMUSP00000057509.3, ENSMUST00000052174.3
    Conserved Domains (1) summary
    cl21590
    Location:15 → 406
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    31745797..31764866
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522119.5 → XP_006522182.1  GPI mannosyltransferase 4 isoform X1

    See identical proteins and their annotated locations for XP_006522182.1

    UniProtKB/Swiss-Prot
    Q149K0, Q8BTP0
    Conserved Domains (1) summary
    cl21590
    Location:15 → 406
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

  2. XM_006522120.5 → XP_006522183.1  GPI mannosyltransferase 4 isoform X1

    See identical proteins and their annotated locations for XP_006522183.1

    UniProtKB/Swiss-Prot
    Q149K0, Q8BTP0
    Conserved Domains (1) summary
    cl21590
    Location:15 → 406
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

  3. XM_006522118.4 → XP_006522181.1  GPI mannosyltransferase 4 isoform X1

    See identical proteins and their annotated locations for XP_006522181.1

    UniProtKB/Swiss-Prot
    Q149K0, Q8BTP0
    Conserved Domains (1) summary
    cl21590
    Location:15 → 406
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BTP0.2 GenPept UniProtKB/Swiss-Prot:Q8BTP0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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