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Zfp870 zinc finger protein 870 [ Mus musculus (house mouse) ]

Gene ID: 240066, updated on 28-Oct-2024

Summary

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Official Symbol
Zfp870provided by MGI
Official Full Name
zinc finger protein 870provided by MGI
Primary source
MGI:MGI:3029586
See related
Ensembl:ENSMUSG00000095325 AllianceGenome:MGI:3029586
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in nervous system and neural retina. [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 1.6), CNS E18 (RPKM 1.4) and 26 other tissues See more
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Genomic context

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See Zfp870 in Genome Data Viewer
Location:
17 B1; 17 17.98 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (33098193..33110621, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (32879221..32891641, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene 7059 Neighboring gene predicted gene, 50050 Neighboring gene STARR-seq mESC enhancer starr_42396 Neighboring gene zinc finger protein 870 pseudogene Neighboring gene STARR-seq mESC enhancer starr_42397 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:33028261-33028519 Neighboring gene STARR-seq mESC enhancer starr_42399 Neighboring gene STARR-seq mESC enhancer starr_42400 Neighboring gene cytochrome P450, family 4, subfamily f, polypeptide 14 Neighboring gene cytochrome P450, family 4, subfamily f, polypeptide 13 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:33084248-33084483

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  2. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC86136

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 870

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001425928.1 → NP_001412857.1  zinc finger protein 870 isoform 1

    Status: VALIDATED

    Source sequence(s)
    CT033772

  2. NM_207245.3 → NP_997128.1  zinc finger protein 870 isoform 2

    See identical proteins and their annotated locations for NP_997128.1

    Status: VALIDATED

    Source sequence(s)
    CT033772
    Consensus CDS
    CCDS89069.1
    UniProtKB/TrEMBL
    Q6NZJ3
    Related
    ENSMUSP00000154207.2, ENSMUST00000228075.3
    Conserved Domains (6) summary
    smart00349
    Location:4 → 53
    KRAB; krueppel associated box
    COG5048
    Location:360 → 548
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:364 → 384
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4 → 43
    KRAB; KRAB box
    pfam13465
    Location:376 → 399
    zf-H2C2_2; Zinc-finger double domain
    cl19284
    Location:265 → 321
    Ribosomal_L37ae; Ribosomal L37ae protein family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    33098193..33110621 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160603.1 → XP_036016496.1  zinc finger protein 870 isoform X2

    Conserved Domains (2) summary
    COG5048
    Location:206 → 394
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:210 → 230
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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