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Rnf13 ring finger protein 13 [ Mus musculus (house mouse) ]

Gene ID: 24017, updated on 2-Nov-2024

Summary

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Official Symbol
Rnf13provided by MGI
Official Full Name
ring finger protein 13provided by MGI
Primary source
MGI:MGI:1346341
See related
Ensembl:ENSMUSG00000036503 AllianceGenome:MGI:1346341
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rzf; 2010001H16Rik
Summary
This gene encodes a member of the PA-TM-RING family of proteins that contain a protease associated (PA) domain and a RING finger domain separated by a transmembrane (TM) domain. The encoded protein is an E3 ubiquitin ligase localized to the endosomal-lysosomal vesicles and inner nuclear membrane. Mice lacking the encoded protein have impaired learning abilities associated with a decreased synaptic vesicle density and dysregulated SNARE complex assembly. Alternative splicing of this gene results in multiple transcript variants. A pseudogene for this gene has been identified on the X chromosome. [provided by RefSeq, Jan 2015]
Expression
Ubiquitous expression in cerebellum adult (RPKM 16.4), bladder adult (RPKM 14.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Rnf13 in Genome Data Viewer
Location:
3 D; 3 28.04 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (57643468..57742846)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (57736044..57835425)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_07737 Neighboring gene ankyrin repeat and ubiquitin domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_07738 Neighboring gene STARR-positive B cell enhancer mm9_chr3:57539802-57540103 Neighboring gene ribosomal protein S11 pseudogene Neighboring gene ribosomal protein L7A pseudogene Neighboring gene ribosomal protein 10 pseudogene Neighboring gene profilin 2 Neighboring gene STARR-seq mESC enhancer starr_07740 Neighboring gene predicted gene, 32753 Neighboring gene predicted gene, 40055 Neighboring gene eukaryotic translation initiation factor 5 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. RING finger protein 13 protects against nonalcoholic steatohepatitis by targeting STING-relayed signaling pathways. Lin Z, et al. Nat Commun, 2023 Oct 20. PMID 37857628, Free PMC Article
  2. Silencing RNF13 Alleviates Parkinson's Disease - Like Problems in Mouse Models by Regulating the Endoplasmic Reticulum Stress-Mediated IRE1α-TRAF2-ASK1-JNK Pathway. Ji M, et al. J Mol Neurosci, 2020 Dec. PMID 32617872
  3. Trafficking and proteolytic processing of RNF13, a model PA-TM-RING family endosomal membrane ubiquitin ligase. Bocock JP, et al. FEBS J, 2011 Jan. PMID 21078126
  4. RNF13: an emerging RING finger ubiquitin ligase important in cell proliferation. Jin X, et al. FEBS J, 2011 Jan. PMID 21078127
  5. E3 ubiquitin ligase RNF123-deficient mice exhibit reduced parasitemia and mortality in rodent malaria (Plasmodium yoelii 17XL) infection. Miyasaka Y, et al. Parasitol Int, 2022 Jun. PMID 35063657

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. E3 Ubiquitin Ligase RNF13 Suppresses TLR Lysosomal Degradation by Promoting LAMP-1 Proteasomal Degradation.
    Title: E3 Ubiquitin Ligase RNF13 Suppresses TLR Lysosomal Degradation by Promoting LAMP-1 Proteasomal Degradation.
  2. RNF13 protects against pathological cardiac hypertrophy through p62-NRF2 pathway.
    Title: RNF13 protects against pathological cardiac hypertrophy through p62-NRF2 pathway.
  3. RING finger protein 13 protects against nonalcoholic steatohepatitis by targeting STING-relayed signaling pathways.
    Title: RING finger protein 13 protects against nonalcoholic steatohepatitis by targeting STING-relayed signaling pathways.
  4. Silencing RNF13 Alleviates Parkinson's Disease - Like Problems in Mouse Models by Regulating the Endoplasmic Reticulum Stress-Mediated IRE1alpha-TRAF2-ASK1-JNK Pathway.
    Title: Silencing RNF13 Alleviates Parkinson's Disease - Like Problems in Mouse Models by Regulating the Endoplasmic Reticulum Stress-Mediated IRE1α-TRAF2-ASK1-JNK Pathway.
  5. host RNF13 affects the concentration of GM-CSF in tumor-bearing lungs
    Title: Enhanced metastasis in RNF13 knockout mice is mediated by a reduction in GM-CSF levels.
  6. These results indicate that RNF13 deficiency promotes skeletal muscle regeneration via the effects on satellite cell niche mediated by IL-4 and IL-6.
    Title: Accelerated regeneration of the skeletal muscle in RNF13-knockout mice is mediated by macrophage-secreted IL-4/IL-6.
  7. RNF13 is involved in the regulation of the SNARE complex, which thereby controls synaptic function.
    Title: E3 ubiquitin ligase RNF13 involves spatial learning and assembly of the SNARE complex.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (4)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables JUN kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables JUN kinase binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in organelle localization IEA
Inferred from Electronic Annotation
more info
  
involved_in organelle localization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of JNK cascade ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein autoubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in late endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosomal membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase RNF13
Names
RING-type E3 ubiquitin transferase RNF13
NP_001106884.1
NP_001291383.1
NP_001291385.1
NP_001344009.1
NP_036013.1
XP_006501521.1
XP_030108468.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113413.4 → NP_001106884.1  E3 ubiquitin-protein ligase RNF13 isoform a precursor

    See identical proteins and their annotated locations for NP_001106884.1

    Status: VALIDATED

    Source sequence(s)
    AC165888
    Consensus CDS
    CCDS50913.1
    UniProtKB/Swiss-Prot
    O54965, O54966, Q6PEA8
    UniProtKB/TrEMBL
    Q3TJV7
    Related
    ENSMUSP00000049331.10, ENSMUST00000041826.14
    Conserved Domains (2) summary
    cd02123
    Location:23 → 180
    PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
    cd16797
    Location:238 → 283
    RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins

  2. NM_001304454.3 → NP_001291383.1  E3 ubiquitin-protein ligase RNF13 isoform c

    See identical proteins and their annotated locations for NP_001291383.1

    Status: VALIDATED

    Source sequence(s)
    AC165888
    Consensus CDS
    CCDS84623.1
    UniProtKB/TrEMBL
    Q3TJV7, Q8CB78
    Related
    ENSMUSP00000142462.2, ENSMUST00000200497.5
    Conserved Domains (2) summary
    cd02123
    Location:23 → 180
    PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
    pfam17123
    Location:240 → 260
    zf-RING_11; RING-like zinc finger

  3. NM_001304456.3 → NP_001291385.1  E3 ubiquitin-protein ligase RNF13 isoform d

    See identical proteins and their annotated locations for NP_001291385.1

    Status: VALIDATED

    Source sequence(s)
    AC165888
    Consensus CDS
    CCDS84622.1
    UniProtKB/TrEMBL
    Q8C4F9
    Related
    ENSMUSP00000143498.2, ENSMUST00000198214.5
    Conserved Domains (1) summary
    cd02123
    Location:23 → 180
    PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...

  4. NM_001357080.2 → NP_001344009.1  E3 ubiquitin-protein ligase RNF13 isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AC165888
    Consensus CDS
    CCDS50913.1
    UniProtKB/Swiss-Prot
    O54965, O54966, Q6PEA8
    UniProtKB/TrEMBL
    Q3TJV7
    Conserved Domains (2) summary
    cd02123
    Location:23 → 180
    PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
    cd16797
    Location:238 → 283
    RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins

  5. NM_001428659.1 → NP_001415588.1  E3 ubiquitin-protein ligase RNF13 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC165888

  6. NM_011883.6 → NP_036013.1  E3 ubiquitin-protein ligase RNF13 isoform b precursor

    See identical proteins and their annotated locations for NP_036013.1

    Status: VALIDATED

    Source sequence(s)
    AC165888
    Consensus CDS
    CCDS79910.1
    UniProtKB/TrEMBL
    Q3UTG4
    Related
    ENSMUSP00000142335.2, ENSMUST00000199041.2
    Conserved Domains (2) summary
    cd02123
    Location:23 → 180
    PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
    pfam17123
    Location:240 → 260
    zf-RING_11; RING-like zinc finger

RNA

  1. NR_130743.3 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC165888
    Related
    ENSMUST00000197205.5

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    57643468..57742846
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252608.2 → XP_030108468.1  E3 ubiquitin-protein ligase RNF13 isoform X1

    UniProtKB/TrEMBL
    Q3TJV7
    Conserved Domains (2) summary
    cd02123
    Location:37 → 153
    PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
    cl17238
    Location:211 → 256
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  2. XM_006501458.5 → XP_006501521.1  E3 ubiquitin-protein ligase RNF13 isoform X1

    Conserved Domains (2) summary
    cd02123
    Location:37 → 153
    PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
    cl17238
    Location:211 → 256
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O54965.2 GenPept UniProtKB/Swiss-Prot:O54965

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