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Iigp1c interferon inducible GTPase 1C [ Mus musculus (house mouse) ]

Gene ID: 240327, updated on 2-Nov-2024

Summary

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Official Symbol
Iigp1cprovided by MGI
Official Full Name
interferon inducible GTPase 1Cprovided by MGI
Primary source
MGI:MGI:3644953
See related
Ensembl:ENSMUSG00000073555 AllianceGenome:MGI:3644953
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm4951; Ifgga2; EG240327
Summary
Predicted to enable GTPase activity. Acts upstream of or within cellular response to interferon-beta. Predicted to be active in endoplasmic reticulum membrane. Used to study metabolic dysfunction-associated steatotic liver disease. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in liver E18 (RPKM 5.3), liver adult (RPKM 4.7) and 3 other tissues See more
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Genomic context

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See Iigp1c in Genome Data Viewer
Location:
18 D3; 18 34.36 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (60345064..60381512)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (60212004..60248440)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 54034 Neighboring gene STARR-seq mESC enhancer starr_44711 Neighboring gene STARR-seq mESC enhancer starr_44712 Neighboring gene zinc finger protein 12 pseudogene Neighboring gene interferon inducible GTPase 1 pseudogene Neighboring gene predicted gene, 45947 Neighboring gene predicted gene, 46635 Neighboring gene predicted gene 4841

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Loss of immunity-related GTPase GM4951 leads to nonalcoholic fatty liver disease without obesity. Zhang Z, et al. Nat Commun, 2022 Jul 16. PMID 35842425, Free PMC Article
  2. Immunity-related GTPase induces lipophagy to prevent excess hepatic lipid accumulation. Schwerbel K, et al. J Hepatol, 2020 Oct. PMID 32376415, Free PMC Article
  3. An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome. Bürckstümmer T, et al. Nat Immunol, 2009 Mar. PMID 19158679
  4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to interferon-beta IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cellular response to interferon-beta IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein LOC240327
Names
interferon-gamma-inducible GTPase Ifgga2 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033767.4 → NP_001028939.1  uncharacterized protein LOC240327

    See identical proteins and their annotated locations for NP_001028939.1

    Status: VALIDATED

    Source sequence(s)
    AC102225
    Consensus CDS
    CCDS29268.1
    UniProtKB/TrEMBL
    Q3UED7, U5NJM4
    Related
    ENSMUSP00000031549.6, ENSMUST00000031549.6
    Conserved Domains (1) summary
    pfam05049
    Location:36 → 402
    IIGP; Interferon-inducible GTPase (IIGP)

  2. NM_001429146.1 → NP_001416075.1  uncharacterized protein LOC240327

    Status: VALIDATED

    Source sequence(s)
    AC102225
    UniProtKB/TrEMBL
    Q3UED7

  3. NM_001429147.1 → NP_001416076.1  uncharacterized protein LOC240327

    Status: VALIDATED

    Source sequence(s)
    AC102225
    UniProtKB/TrEMBL
    Q3UED7

  4. NM_001429148.1 → NP_001416077.1  uncharacterized protein LOC240327

    Status: VALIDATED

    Source sequence(s)
    AC102225
    UniProtKB/TrEMBL
    Q3UED7

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    60345064..60381512
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011246928.4 → XP_011245230.1  uncharacterized protein LOC240327 isoform X1

    Conserved Domains (1) summary
    pfam05049
    Location:36 → 402
    IIGP; Interferon-inducible GTPase (IIGP)

  2. XM_011246929.4 → XP_011245231.1  uncharacterized protein LOC240327 isoform X1

    Conserved Domains (1) summary
    pfam05049
    Location:36 → 402
    IIGP; Interferon-inducible GTPase (IIGP)

  3. XM_006525925.5 → XP_006525988.1  uncharacterized protein LOC240327 isoform X1

    Conserved Domains (1) summary
    pfam05049
    Location:36 → 402
    IIGP; Interferon-inducible GTPase (IIGP)
Nucleotide Protein Strain
Heading Accession and Version

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