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Slc6a7 solute carrier family 6 (neurotransmitter transporter, L-proline), member 7 [ Mus musculus (house mouse) ]

Gene ID: 240332, updated on 2-Nov-2024

Summary

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Official Symbol
Slc6a7provided by MGI
Official Full Name
solute carrier family 6 (neurotransmitter transporter, L-proline), member 7provided by MGI
Primary source
MGI:MGI:2147363
See related
Ensembl:ENSMUSG00000052026 AllianceGenome:MGI:2147363
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PROT
Summary
Enables L-proline transmembrane transporter activity. Acts upstream of or within proline transmembrane transport. Predicted to be located in synaptic membrane. Predicted to be active in several cellular components, including Schaffer collateral - CA1 synapse; presynaptic membrane; and synaptic vesicle membrane. Is expressed in brain; early conceptus; metanephros; and secondary oocyte. Orthologous to human SLC6A7 (solute carrier family 6 member 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in frontal lobe adult (RPKM 8.4), cortex adult (RPKM 7.4) and 11 other tissues See more
Orthologs
human all
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Genomic context

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See Slc6a7 in Genome Data Viewer
Location:
18 E1; 18 34.41 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (61128448..61147484, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (60995376..61014416, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene calcium/calmodulin-dependent protein kinase II alpha Neighboring gene microRNA 7220 Neighboring gene microRNA 6982 Neighboring gene STARR-positive B cell enhancer ABC_E10994 Neighboring gene caudal type homeobox 1 Neighboring gene predicted gene, 52351 Neighboring gene platelet derived growth factor receptor, beta polypeptide

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Inactivation of the Mouse L-Proline Transporter PROT Alters Glutamatergic Synapse Biochemistry and Perturbs Behaviors Required to Respond to Environmental Changes. Schulz D, et al. Front Mol Neurosci, 2018. PMID 30177871, Free PMC Article
  2. SIT1 is a betaine/proline transporter that is activated in mouse eggs after fertilization and functions until the 2-cell stage. Anas MK, et al. Development, 2008 Dec. PMID 19029042
  3. Lhx2 specifies regional fate in Emx1 lineage of telencephalic progenitors generating cerebral cortex. Chou SJ, et al. Nat Neurosci, 2009 Nov. PMID 19820705, Free PMC Article
  4. The repertoire of solute carriers of family 6: identification of new human and rodent genes. Höglund PJ, et al. Biochem Biophys Res Commun, 2005 Oct 14. PMID 16125675
  5. Expansion of the piriform cortex contributes to corticothalamic pathfinding defects in Gli3 conditional mutants. Amaniti EM, et al. Cereb Cortex, 2015 Feb. PMID 24014668

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We assessed two candidates for the betaine/proline transporter: SIT1 (IMINO; encoded by Slc6a20a) and PROT (Slc6a7). mRNA from both genes was present in eggs and 1-cell embryos.
    Title: SIT1 is a betaine/proline transporter that is activated in mouse eggs after fertilization and functions until the 2-cell stage.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC61029, MGC67444

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-proline transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-proline transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables L-proline transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables proline:sodium symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables proline:sodium symporter activity ISO
Inferred from Sequence Orthology
more info
  
enables proline:sodium symporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in glycine import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neurotransmitter transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within proline transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proline transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proline transport ISO
Inferred from Sequence Orthology
more info
  
involved_in proline transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in sodium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  
located_in synaptic membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
sodium-dependent proline transporter
Names
solute carrier family 6 member 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418406.1 → NP_001405335.1  sodium-dependent proline transporter isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC124431

  2. NM_201353.2 → NP_958741.1  sodium-dependent proline transporter isoform 1

    See identical proteins and their annotated locations for NP_958741.1

    Status: VALIDATED

    Source sequence(s)
    AC124431
    Consensus CDS
    CCDS29278.1
    UniProtKB/Swiss-Prot
    Q6PGE7, Q80UM1
    Related
    ENSMUSP00000025520.8, ENSMUST00000025520.10
    Conserved Domains (1) summary
    cl00456
    Location:37 → 581
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    61128448..61147484 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250459.2 → XP_030106319.1  sodium-dependent proline transporter isoform X3

    Conserved Domains (1) summary
    cl00456
    Location:1 → 500
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  2. XM_006525930.4 → XP_006525993.1  sodium-dependent proline transporter isoform X1

    See identical proteins and their annotated locations for XP_006525993.1

    Conserved Domains (1) summary
    cl00456
    Location:84 → 628
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  3. XM_006525929.4 → XP_006525992.1  sodium-dependent proline transporter isoform X1

    See identical proteins and their annotated locations for XP_006525992.1

    Conserved Domains (1) summary
    cl00456
    Location:84 → 628
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  4. XM_006525931.5 → XP_006525994.1  sodium-dependent proline transporter isoform X2

    Conserved Domains (1) summary
    cl00456
    Location:19 → 563
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  5. XM_006525932.3 → XP_006525995.1  sodium-dependent proline transporter isoform X3

    See identical proteins and their annotated locations for XP_006525995.1

    Conserved Domains (1) summary
    cl00456
    Location:1 → 500
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  6. XM_017317902.3 → XP_017173391.1  sodium-dependent proline transporter isoform X4

    Conserved Domains (1) summary
    cl00456
    Location:84 → 410
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  7. XM_011246931.1 → XP_011245233.1  sodium-dependent proline transporter isoform X5

    Conserved Domains (1) summary
    cl00456
    Location:84 → 336
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  8. XM_006525935.4 → XP_006525998.1  sodium-dependent proline transporter isoform X6

    Conserved Domains (1) summary
    cl00456
    Location:84 → 333
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PGE7.1 GenPept UniProtKB/Swiss-Prot:Q6PGE7

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