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Lipk lipase, family member K [ Mus musculus (house mouse) ]

Gene ID: 240633, updated on 28-Oct-2024

Summary

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Official Symbol
Lipkprovided by MGI
Official Full Name
lipase, family member Kprovided by MGI
Primary source
MGI:MGI:2679259
See related
Ensembl:ENSMUSG00000024771 AllianceGenome:MGI:2679259
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lipl2; 9930115F20
Summary
Predicted to enable hydrolase activity, acting on ester bonds. Predicted to be involved in lipid catabolic process. Predicted to be located in extracellular region. Predicted to be active in intracellular membrane-bounded organelle. Orthologous to human LIPK (lipase family member K). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Low expression observed in reference dataset See more
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Genomic context

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See Lipk in Genome Data Viewer
Location:
19 C1; 19 29.3 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (33985654..34025303)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (34008254..34047903)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 23095 Neighboring gene lipase, gastric Neighboring gene STARR-seq mESC enhancer starr_45986 Neighboring gene predicted gene, 31300 Neighboring gene lipase, family member N

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  2. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  3. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  4. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article
  5. Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. Carninci P, et al. Genome Res, 2000 Oct. PMID 11042159, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC67675

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity, acting on ester bonds IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
lipase member K
Names
lipase-like abhydrolase domain-containing protein 2
lipase-like, ab-hydrolase domain containing 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001205349.1 → NP_001192278.1  lipase member K isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC102119
    Consensus CDS
    CCDS57143.1
    UniProtKB/Swiss-Prot
    Q8BM14
    Related
    ENSMUSP00000053913.7, ENSMUST00000054260.8
    Conserved Domains (3) summary
    pfam00561
    Location:83 → 382
    Abhydrolase_1; alpha/beta hydrolase fold
    pfam04083
    Location:40 → 101
    Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
    pfam12695
    Location:82 → 210
    Abhydrolase_5; Alpha/beta hydrolase family

  2. NM_172837.4 → NP_766425.1  lipase member K isoform 2 precursor

    See identical proteins and their annotated locations for NP_766425.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC102119, AK037106, BY150606
    Consensus CDS
    CCDS89381.1
    UniProtKB/Swiss-Prot
    Q7TML7, Q8BM14
    Related
    ENSMUSP00000152955.2, ENSMUST00000225505.2
    Conserved Domains (3) summary
    pfam00561
    Location:78 → 377
    Abhydrolase_1; alpha/beta hydrolase fold
    pfam04083
    Location:34 → 96
    Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
    pfam12695
    Location:77 → 205
    Abhydrolase_5; Alpha/beta hydrolase family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    33985654..34025303
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BM14.1 GenPept UniProtKB/Swiss-Prot:Q8BM14

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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