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Brinp2 bone morphogenic protein/retinoic acid inducible neural-specific 2 [ Mus musculus (house mouse) ]

Gene ID: 240843, updated on 2-Nov-2024

Summary

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Official Symbol
Brinp2provided by MGI
Official Full Name
bone morphogenic protein/retinoic acid inducible neural-specific 2provided by MGI
Primary source
MGI:MGI:2443333
See related
Ensembl:ENSMUSG00000004031 AllianceGenome:MGI:2443333
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fam5b; mKIAA1747; 6430517E21Rik
Summary
Involved in cellular response to retinoic acid; central nervous system neuron differentiation; and negative regulation of mitotic cell cycle. Acts upstream of or within locomotion and nervous system development. Predicted to be located in extracellular region. Predicted to be active in cytoplasm; dendrite; and neuronal cell body. Is expressed in cortical antihem and cortical plate. Human ortholog(s) of this gene implicated in oral squamous cell carcinoma. Orthologous to human BRINP2 (BMP/retinoic acid inducible neural specific 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in frontal lobe adult (RPKM 16.1), cortex adult (RPKM 14.4) and 7 other tissues See more
Orthologs
human all
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Genomic context

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See Brinp2 in Genome Data Viewer
Location:
1 H1; 1 68.27 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (158072835..158185096, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (158245265..158356528, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 51855 Neighboring gene predicted gene, 39686 Neighboring gene STARR-seq mESC enhancer starr_02774 Neighboring gene STARR-seq mESC enhancer starr_02775 Neighboring gene VISTA enhancer mm1369 Neighboring gene STARR-seq mESC enhancer starr_02777 Neighboring gene astrotactin 1 Neighboring gene predicted gene, 37679 Neighboring gene microRNA 488 Neighboring gene STARR-seq mESC enhancer starr_02778 Neighboring gene predicted gene, 53639 Neighboring gene pappalysin 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mice Lacking Brinp2 or Brinp3, or Both, Exhibit Behaviors Consistent with Neurodevelopmental Disorders. Berkowicz SR, et al. Front Behav Neurosci, 2016. PMID 27826231, Free PMC Article
  2. Analysis of the expression and function of BRINP family genes during neuronal differentiation in mouse embryonic stem cell-derived neural stem cells. Terashima M, et al. J Neurosci Res, 2010 May 15. PMID 20025061
  3. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553
  4. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to retinoic acid IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to retinoic acid IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in central nervous system neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in central nervous system neuron differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within locomotion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of mitotic cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within nervous system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
BMP/retinoic acid-inducible neural-specific protein 2
Names
family with sequence similarity 5, member B
protein FAM5B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207583.2 → NP_997466.2  BMP/retinoic acid-inducible neural-specific protein 2 precursor

    See identical proteins and their annotated locations for NP_997466.2

    Status: VALIDATED

    Source sequence(s)
    BC076572, CO043107
    Consensus CDS
    CCDS15401.1
    UniProtKB/Swiss-Prot
    Q6DFY8, Q80T96
    Related
    ENSMUSP00000004133.9, ENSMUST00000004133.11
    Conserved Domains (1) summary
    smart00457
    Location:90 → 281
    MACPF; membrane-attack complex / perforin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    158072835..158185096 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496837.2 → XP_006496900.1  BMP/retinoic acid-inducible neural-specific protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006496900.1

    UniProtKB/Swiss-Prot
    Q6DFY8, Q80T96
    Conserved Domains (1) summary
    smart00457
    Location:90 → 281
    MACPF; membrane-attack complex / perforin

  2. XM_006496836.2 → XP_006496899.1  BMP/retinoic acid-inducible neural-specific protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006496899.1

    UniProtKB/Swiss-Prot
    Q6DFY8, Q80T96
    Conserved Domains (1) summary
    smart00457
    Location:90 → 281
    MACPF; membrane-attack complex / perforin

  3. XM_011238810.2 → XP_011237112.1  BMP/retinoic acid-inducible neural-specific protein 2 isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6DFY8.1 GenPept UniProtKB/Swiss-Prot:Q6DFY8

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