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cima-1 Major facilitator superfamily (MFS) profile domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 24104589, updated on 2-Nov-2024

Summary

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Official Symbol
cima-1
Official Full Name
Major facilitator superfamily (MFS) profile domain-containing protein
Primary source
WormBase:WBGene00018473
Locus tag
CELE_F45E4.11
See related
AllianceGenome:WB:WBGene00018473
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable sialic acid transmembrane transporter activity. Involved in regulation of protein catabolic process and regulation of synapse organization. Located in lysosome. Is expressed in hypodermis and intestine. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See cima-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
8
Sequence:
Chromosome: IV; NC_003282.8 (7651459..7654295)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Neuropeptide-Like Protein Neighboring gene HMG box-containing protein 5 Neighboring gene ANK_REP_REGION domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Activin_recp domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Glia Promote Synaptogenesis through an IQGAP PES-7 in C. elegans. Dong X, et al. Cell Rep, 2020 Feb 25. PMID 32101740
  2. Synapse location during growth depends on glia location. Shao Z, et al. Cell, 2013 Jul 18. PMID 23870123, Free PMC Article
  3. Temperature regulates synaptic subcellular specificity mediated by inhibitory glutamate signaling. Wang M, et al. PLoS Genet, 2021 Jan. PMID 33428618, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables sialic acid transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in monoatomic anion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of synapse organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sialic acid transport ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in sodium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in lysosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Major facilitator superfamily (MFS) profile domain-containing protein
NP_001294208.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    7651459..7654295
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001307279.4 → NP_001294208.1  Major facilitator superfamily (MFS) profile domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294208.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O44130
    Conserved Domains (1) summary
    TIGR00894
    Location:63 → 506
    2A0114euk; Na(+)-dependent inorganic phosphate cotransporter
Nucleotide Protein
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