U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ptp-2 Tyrosine-protein phosphatase non-receptor type ptp-2 [ Caenorhabditis elegans ]

Gene ID: 24104681, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
ptp-2
Official Full Name
Tyrosine-protein phosphatase non-receptor type ptp-2
Primary source
WormBase:WBGene00004214
Locus tag
CELE_F59G1.5
See related
AllianceGenome:WB:WBGene00004214
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable non-membrane spanning protein tyrosine phosphatase activity and phosphotyrosine residue binding activity. Involved in several processes, including nematode larval development; positive regulation of signal transduction; and positive regulation of vulval development. Located in cytoplasmic vesicle. Is expressed in body wall musculature; head ganglion; pharynx; spermatheca; and tail. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); Noonan syndrome with multiple lentigines 1; atrophic gastritis; juvenile myelomonocytic leukemia; and metachondromatosis. Orthologous to several human genes including PTPN6 (protein tyrosine phosphatase non-receptor type 6). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ptp-2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
6
Sequence:
Chromosome: II; NC_003280.10 (5918647..5921617)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Ceramide glucosyltransferase 3 Neighboring gene ncRNA Neighboring gene Frataxin, mitochondrial Neighboring gene Serine/threonine-protein kinase VRK1 Neighboring gene ncRNA

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. MSP hormonal control of the oocyte MAP kinase cascade and reactive oxygen species signaling. Yang Y, et al. Dev Biol, 2010 Jun 1. PMID 20380830, Free PMC Article
  2. The frataxin-encoding operon of Caenorhabditis elegans shows complex structure and regulation. Vázquez-Manrique RP, et al. Genomics, 2007 Mar. PMID 17174523
  3. The adaptor protein soc-1/Gab1 modifies growth factor receptor output in Caenorhabditis elegans. Hopper NA. Genetics, 2006 May. PMID 16547100, Free PMC Article
  4. trans-Fatty acids facilitate DNA damage-induced apoptosis through the mitochondrial JNK-Sab-ROS positive feedback loop. Hirata Y, et al. Sci Rep, 2020 Feb 17. PMID 32066809, Free PMC Article
  5. The Caenorhabditis elegans SH2 domain-containing protein tyrosine phosphatase PTP-2 participates in signal transduction during oogenesis and vulval development. Gutch MJ, et al. Genes Dev, 1998 Feb 15. PMID 9472025, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables non-membrane spanning protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphotyrosine residue binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in muscle organ development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nematode larval development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in oogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in oogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of Ras protein signal transduction IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of epidermal growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of vulval development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell projection organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
Tyrosine-protein phosphatase non-receptor type ptp-2
NP_001293512.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    5918647..5921617
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001306583.2 → NP_001293512.1  Tyrosine-protein phosphatase non-receptor type ptp-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293512.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EC24
    Conserved Domains (4) summary
    cd10340
    Location:10 → 114
    SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    smart00194
    Location:263 → 579
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00252
    Location:132 → 217
    SH2; Src homology 2 domains
    cd00047
    Location:294 → 578
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5EC24.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Miscellaneous