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unc-17 Vesicular acetylcholine transporter unc-17 [ Caenorhabditis elegans ]

Gene ID: 24105312, updated on 2-Nov-2024

Summary

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Official Symbol
unc-17
Official Full Name
Vesicular acetylcholine transporter unc-17
Primary source
WormBase:WBGene00006756
Locus tag
CELE_UNC-17
See related
AllianceGenome:WB:WBGene00006756
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables acetylcholine transmembrane transporter activity. Involved in several processes, including cholinergic synaptic transmission; nematode larval development; and regulation of nematode pharyngeal pumping. Located in several cellular components, including excitatory synapse; neuron projection; and synaptic vesicle. Is expressed in several structures, including head; midbody; neurons; somatic nervous system; and tail. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 21. Orthologous to human SLC18A3 (solute carrier family 18 member A3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See unc-17 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
4
Sequence:
Chromosome: IV; NC_003282.8 (3618259..3624699, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene BRCT domain-containing protein Neighboring gene Stress-activated protein kinase JNK Neighboring gene Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal domain-containing protein Neighboring gene Choline O-acetyltransferase Neighboring gene Cysteine-rich transmembrane CYSTM domain-containing protein Neighboring gene ncRNA Neighboring gene MADF domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Analysis of point mutants in the Caenorhabditis elegans vesicular acetylcholine transporter reveals domains involved in substrate translocation. Zhu H, et al. J Biol Chem, 2001 Nov 9. PMID 11551909
  2. A comparison of electrically evoked and channel rhodopsin-evoked postsynaptic potentials in the pharyngeal system of Caenorhabditis elegans. Franks CJ, et al. Invert Neurosci, 2009 Mar. PMID 19294439
  3. Cloning and expression of the vesamicol binding protein from the marine ray Torpedo. Homology with the putative vesicular acetylcholine transporter UNC-17 from Caenorhabditis elegans. Varoqui H, et al. FEBS Lett, 1994 Mar 28. PMID 8143858
  4. Genetic interactions between UNC-17/VAChT and a novel transmembrane protein in Caenorhabditis elegans. Mathews EA, et al. Genetics, 2012 Dec. PMID 23051648, Free PMC Article
  5. Unusual regulation of splicing of the cholinergic locus in Caenorhabditis elegans. Mathews EA, et al. Genetics, 2015 Mar. PMID 25571900, Free PMC Article

See all (112) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Allele-specific suppression in Caenorhabditis elegans reveals details of EMS mutagenesis and a possible moonlighting interaction between the vesicular acetylcholine transporter and ERD2 receptors.
    Title: Allele-specific suppression in Caenorhabditis elegans reveals details of EMS mutagenesis and a possible moonlighting interaction between the vesicular acetylcholine transporter and ERD2 receptors.
  2. An unusual type of splicing regulation in the cholinergic gene locus (CGL) (containing unc-17 and cha-1 genes), mediated by two pairs of complementary sequence elements within the locus was identified.
    Title: Unusual regulation of splicing of the cholinergic locus in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables acetylcholine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetylcholine transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables acetylcholine transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables xenobiotic transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in acetylcholine transport ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in acetylcholine transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nematode larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neurotransmitter transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of locomotion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of muscle contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of nematode pharyngeal pumping IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of nematode pharyngeal pumping IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of neurotransmitter secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic transmission, cholinergic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in xenobiotic transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of AP-1 adaptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of AP-2 adaptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in excitatory synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuron projection IDA
Inferred from Direct Assay
more info
 PubMed 
located_in organelle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
  
located_in synaptic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synaptic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in synaptic vesicle membrane NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in terminal bouton IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Vesicular acetylcholine transporter unc-17
NP_001379838.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    3618259..3624699 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001392284.1 → NP_001379838.1  Vesicular acetylcholine transporter unc-17 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34711
    UniProtKB/TrEMBL
    V9H0X5
    Conserved Domains (1) summary
    cd17383
    Location:34 → 449
    MFS_SLC18A3_VAChT; Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator Superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34711.1

Gene LinkOut

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Molecular Biology Databases
Research Materials