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Zbtb34 zinc finger and BTB domain containing 34 [ Mus musculus (house mouse) ]

Gene ID: 241311, updated on 2-Nov-2024

Summary

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Official Symbol
Zbtb34provided by MGI
Official Full Name
zinc finger and BTB domain containing 34provided by MGI
Primary source
MGI:MGI:2685195
See related
Ensembl:ENSMUSG00000068966 AllianceGenome:MGI:2685195
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm349; mKIAA1993
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to be active in nucleoplasm. Is expressed in olfactory epithelium and submandibular gland primordium. Orthologous to human ZBTB34 (zinc finger and BTB domain containing 34). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in limb E14.5 (RPKM 5.1), CNS E18 (RPKM 4.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Zbtb34 in Genome Data Viewer
Location:
2 B; 2 22.44 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (33296121..33321339, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (33406108..33431324, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene Ral GEF with PH domain and SH3 binding motif 1 Neighboring gene predicted gene, 23546 Neighboring gene angiopoietin-like 2 Neighboring gene STARR-seq mESC enhancer starr_04235 Neighboring gene STARR-seq mESC enhancer starr_04237 Neighboring gene STARR-seq mESC enhancer starr_04239 Neighboring gene STARR-seq mESC enhancer starr_04240 Neighboring gene STARR-seq mESC enhancer starr_04241 Neighboring gene predicted gene 13536 Neighboring gene STARR-seq mESC enhancer starr_04242 Neighboring gene zinc finger and BTB domain containing 43 Neighboring gene predicted gene 13530

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PITX2c is expressed in the adult left atrium, and reducing Pitx2c expression promotes atrial fibrillation inducibility and complex changes in gene expression. Kirchhof P, et al. Circ Cardiovasc Genet, 2011 Apr. PMID 21282332
  2. ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex. Medeiros de Araújo JA, et al. Development, 2021 Aug 15. PMID 34351428, Free PMC Article
  3. A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal. Gagliardi A, et al. EMBO J, 2013 Aug 14. PMID 23892456, Free PMC Article
  4. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
  5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of immune system process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger and BTB domain-containing protein 34

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001085507.2 → NP_001078976.1  zinc finger and BTB domain-containing protein 34 isoform 1

    See identical proteins and their annotated locations for NP_001078976.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL928955
    Consensus CDS
    CCDS38106.1
    UniProtKB/TrEMBL
    A2ATY4, Q69Z45
    Related
    ENSMUSP00000108783.2, ENSMUST00000113158.8
    Conserved Domains (5) summary
    smart00355
    Location:390 → 412
    ZnF_C2H2; zinc finger
    sd00017
    Location:392 → 412
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18220
    Location:25 → 144
    BTB_POZ_ZBTB34; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34)
    pfam00096
    Location:446 → 467
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:404 → 429
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001276332.2 → NP_001263261.1  zinc finger and BTB domain-containing protein 34 isoform 2

    See identical proteins and their annotated locations for NP_001263261.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region and uses a downstream start codon compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AL928955
    UniProtKB/TrEMBL
    Q69Z45
    Conserved Domains (5) summary
    smart00355
    Location:372 → 394
    ZnF_C2H2; zinc finger
    sd00017
    Location:374 → 394
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:428 → 449
    zf-C2H2; Zinc finger, C2H2 type
    cd18220
    Location:7 → 126
    BTB_POZ_ZBTB34; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34)
    pfam13465
    Location:386 → 411
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001411211.1 → NP_001398140.1  zinc finger and BTB domain-containing protein 34 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL928955
    UniProtKB/TrEMBL
    A2ATY4
    Related
    ENSMUSP00000088560.3, ENSMUST00000091037.3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    33296121..33321339 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498041.5 → XP_006498104.1  zinc finger and BTB domain-containing protein 34 isoform X2

    See identical proteins and their annotated locations for XP_006498104.1

    UniProtKB/TrEMBL
    Q69Z45
    Conserved Domains (5) summary
    smart00355
    Location:372 → 394
    ZnF_C2H2; zinc finger
    sd00017
    Location:374 → 394
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:428 → 449
    zf-C2H2; Zinc finger, C2H2 type
    cd18220
    Location:7 → 126
    BTB_POZ_ZBTB34; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34)
    pfam13465
    Location:386 → 411
    zf-H2C2_2; Zinc-finger double domain

  2. XM_036161825.1 → XP_036017718.1  zinc finger and BTB domain-containing protein 34 isoform X1

    UniProtKB/TrEMBL
    A2ATY4, Q69Z45
    Conserved Domains (5) summary
    smart00355
    Location:390 → 412
    ZnF_C2H2; zinc finger
    sd00017
    Location:392 → 412
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18220
    Location:25 → 144
    BTB_POZ_ZBTB34; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34)
    pfam00096
    Location:446 → 467
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:404 → 429
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein
Heading Accession and Version

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