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Fam171b family with sequence similarity 171, member B [ Mus musculus (house mouse) ]

Gene ID: 241520, updated on 2-Nov-2024

Summary

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Official Symbol
Fam171bprovided by MGI
Official Full Name
family with sequence similarity 171, member Bprovided by MGI
Primary source
MGI:MGI:2444579
See related
Ensembl:ENSMUSG00000048388 AllianceGenome:MGI:2444579
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D430039N05Rik
Summary
Is active in synapse. Is expressed in central nervous system; dorsal root ganglion; sensory organ; and trigeminal nerve. Orthologous to human FAM171B (family with sequence similarity 171 member B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in frontal lobe adult (RPKM 51.1), cortex adult (RPKM 29.7) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Fam171b in Genome Data Viewer
Location:
2 D; 2 49.33 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (83642889..83713878)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (83812563..83883534)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7831 Neighboring gene STARR-positive B cell enhancer mm9_chr2:83505584-83505885 Neighboring gene zinc finger CCCH-type containing 15 Neighboring gene STARR-seq mESC enhancer starr_04989 Neighboring gene DNA methyltransferase 3-like, pseudogene 1 Neighboring gene integrin alpha V Neighboring gene STARR-positive B cell enhancer ABC_E2039 Neighboring gene STARR-positive B cell enhancer ABC_E7832 Neighboring gene zinc finger SWIM-type containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E11143 Neighboring gene CWC22 spliceosome-associated protein, retrotransposed 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Action potential-coupled Rho GTPase signaling drives presynaptic plasticity. O'Neil SD, et al. Elife, 2021 Jul 16. PMID 34269176, Free PMC Article
  2. Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome. Unda BK, et al. Mol Psychiatry, 2023 Apr. PMID 36604605, Free PMC Article
  3. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873
  4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  5. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
protein FAM171B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175514.3 → NP_780723.1  protein FAM171B precursor

    See identical proteins and their annotated locations for NP_780723.1

    Status: VALIDATED

    Source sequence(s)
    AL772256, AL772301
    Consensus CDS
    CCDS16182.1
    UniProtKB/Swiss-Prot
    Q14CH0, Q8C756, Q8CAF3, Q8CBZ4, Q8CFT5
    Related
    ENSMUSP00000062702.4, ENSMUST00000051454.4
    Conserved Domains (1) summary
    pfam10577
    Location:82 → 821
    UPF0560; uncharacterized protein family UPF0560

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    83642889..83713878
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161886.1 → XP_036017779.1  protein FAM171B isoform X2

    UniProtKB/Swiss-Prot
    Q14CH0, Q8C756, Q8CAF3, Q8CBZ4, Q8CFT5
    Conserved Domains (1) summary
    pfam10577
    Location:82 → 681
    UPF0560; Uncharacterized protein family UPF0560

  2. XM_006499465.3 → XP_006499528.1  protein FAM171B isoform X1

    UniProtKB/Swiss-Prot
    Q14CH0, Q8C756, Q8CAF3, Q8CBZ4, Q8CFT5
    Conserved Domains (1) summary
    pfam10577
    Location:6 → 745
    UPF0560; Uncharacterized protein family UPF0560
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14CH0.2 GenPept UniProtKB/Swiss-Prot:Q14CH0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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