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Ldlrad3 low density lipoprotein receptor class A domain containing 3 [ Mus musculus (house mouse) ]

Gene ID: 241576, updated on 2-Nov-2024

Summary

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Official Symbol
Ldlrad3provided by MGI
Official Full Name
low density lipoprotein receptor class A domain containing 3provided by MGI
Primary source
MGI:MGI:2138856
See related
Ensembl:ENSMUSG00000048058 AllianceGenome:MGI:2138856
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lrad3; 6430500P08
Summary
Enables amyloid-beta binding activity. Acts upstream of or within receptor-mediated endocytosis and regulation of protein processing. Located in plasma membrane. Is expressed in cranial ganglion; dorsal root ganglion; and gut. Orthologous to human LDLRAD3 (low density lipoprotein receptor class A domain containing 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in limb E14.5 (RPKM 16.1), CNS E11.5 (RPKM 7.6) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Ldlrad3 in Genome Data Viewer
Location:
2 E2; 2 54.11 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (101780546..102016805, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (101950201..102186460, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5949 Neighboring gene STARR-seq mESC enhancer starr_05236 Neighboring gene proline rich 5 like Neighboring gene STARR-seq mESC enhancer starr_05237 Neighboring gene STARR-positive B cell enhancer ABC_E2043 Neighboring gene STARR-seq mESC enhancer starr_05238 Neighboring gene COMM domain containing 9 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:101819193-101819405 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:101831937-101832164 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:101833086-101833410 Neighboring gene predicted gene, 39888 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:101870916-101871189 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:101879569-101879838 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:101916542-101916651 Neighboring gene predicted gene, 54138 Neighboring gene predicted gene 13919 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:101957603-101957826 Neighboring gene STARR-seq mESC enhancer starr_05244 Neighboring gene STARR-seq mESC enhancer starr_05248 Neighboring gene STARR-seq mESC enhancer starr_05249 Neighboring gene 60S ribosomal protein L29 pseudogene Neighboring gene predicted gene 13866 Neighboring gene predicted gene, 34268

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Entry receptor LDLRAD3 is required for Venezuelan equine encephalitis virus peripheral infection and neurotropism leading to pathogenesis in mice. Kafai NM, et al. Cell Rep, 2023 Aug 29. PMID 37556325, Free PMC Article
  2. LDLRAD3 is a receptor for Venezuelan equine encephalitis virus. Ma H, et al. Nature, 2020 Dec. PMID 33208938, Free PMC Article
  3. LRAD3, a novel low-density lipoprotein receptor family member that modulates amyloid precursor protein trafficking. Ranganathan S, et al. J Neurosci, 2011 Jul 27. PMID 21795536, Free PMC Article
  4. Regulation of Itch and Nedd4 E3 Ligase Activity and Degradation by LRAD3. Noyes NC, et al. Biochemistry, 2016 Mar 1. PMID 26854353
  5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Entry receptor LDLRAD3 is required for Venezuelan equine encephalitis virus peripheral infection and neurotropism leading to pathogenesis in mice.
    Title: Entry receptor LDLRAD3 is required for Venezuelan equine encephalitis virus peripheral infection and neurotropism leading to pathogenesis in mice.
  2. LDLRAD3 is a receptor for Venezuelan equine encephalitis virus.
    Title: LDLRAD3 is a receptor for Venezuelan equine encephalitis virus.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3)  1 citation
  • Gene trapped (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables amyloid-beta binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in receptor-mediated endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within receptor-mediated endocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of protein processing IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
low-density lipoprotein receptor class A domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290784.1 → NP_001277713.1  low-density lipoprotein receptor class A domain-containing protein 3 isoform b precursor

    See identical proteins and their annotated locations for NP_001277713.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (b) that is 1 aa shorter than isoform a.
    Source sequence(s)
    AK032208, BB349367, BX322585, BX571894
    UniProtKB/TrEMBL
    B7ZND2
    Conserved Domains (1) summary
    cd00112
    Location:32 → 64
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

  2. NM_178886.3 → NP_849217.2  low-density lipoprotein receptor class A domain-containing protein 3 isoform a precursor

    See identical proteins and their annotated locations for NP_849217.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK032208, BB349367, BX322585, BX571894
    Consensus CDS
    CCDS38187.1
    UniProtKB/Swiss-Prot
    A2AR95, A2AR96, Q8CCS0, Q8CDR7
    UniProtKB/TrEMBL
    B2RR20
    Related
    ENSMUSP00000054134.6, ENSMUST00000058790.12
    Conserved Domains (1) summary
    cd00112
    Location:32 → 64
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    101780546..102016805 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161917.1 → XP_036017810.1  low-density lipoprotein receptor class A domain-containing protein 3 isoform X2

    Conserved Domains (1) summary
    cd00112
    Location:39 → 74
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

  2. XM_006499481.4 → XP_006499544.1  low-density lipoprotein receptor class A domain-containing protein 3 isoform X1

    UniProtKB/Swiss-Prot
    A2AR95
    Related
    ENSMUSP00000106853.2, ENSMUST00000111222.2
    Conserved Domains (1) summary
    cd00112
    Location:39 → 74
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

  3. XM_006499482.1 → XP_006499545.1  low-density lipoprotein receptor class A domain-containing protein 3 isoform X3

    Conserved Domains (2) summary
    cd00112
    Location:36 → 71
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00057
    Location:2 → 29
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2AR95.1 GenPept UniProtKB/Swiss-Prot:A2AR95

Gene LinkOut

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