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Acp2 acid phosphatase 2, lysosomal [ Rattus norvegicus (Norway rat) ]

Gene ID: 24162, updated on 2-Nov-2024

Summary

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Official Symbol
Acp2provided by RGD
Official Full Name
acid phosphatase 2, lysosomalprovided by RGD
Primary source
RGD:2021
See related
EnsemblRapid:ENSRNOG00000013594 AllianceGenome:RGD:2021
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
LAP
Summary
The protein encoded by this gene belongs to the histidine acid phosphatase family, which hydrolyze orthophosphoric monoesters to alcohol and phosphate. This protein is localized to the lysosomal membrane, and is chemically and genetically distinct from the red cell acid phosphatase. Mice lacking this gene showed multiple defects, including bone structure alterations, lysosomal storage defects, and an increased tendency towards seizures. An enzymatically-inactive allele of this gene showed severe growth retardation, hair-follicle abnormalities, and an ataxia-like phenotype. Two isoforms are predicted to be produced from the same mRNA by the use of alternative in-frame translation termination codons via a stop codon readthrough mechanism. [provided by RefSeq, Oct 2017]
Expression
Biased expression in Liver (RPKM 164.8), Kidney (RPKM 156.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Acp2 in Genome Data Viewer
Location:
3q24
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (97630654..97642601)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (77175022..77185180)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (80020346..80030365)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene transfer RNA alanine (anticodon AGC) 34 Neighboring gene U6 spliceosomal RNA Neighboring gene nuclear receptor subfamily 1, group H, member 3 Neighboring gene damage specific DNA binding protein 2 Neighboring gene protein kinase C and casein kinase substrate in neurons 3 Neighboring gene ARF GTPase activating protein 2 Neighboring gene centriolar satellite-associated tubulin polyglutamylase complex regulator 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Isolation and sequencing of a cDNA clone encoding acid phosphatase in rat liver lysosomes. Himeno M, et al. Biochem Biophys Res Commun, 1989 Aug 15. PMID 2764916
  2. Synthesis and transport of lysosomal acid phosphatase in normal and I-cell fibroblasts. Lemansky P, et al. J Biol Chem, 1985 Jul 25. PMID 3160696
  3. Dephosphorylation of tyrosine phosphorylated synthetic peptides by rat liver phosphotyrosine protein phosphatase isoenzymes. Stefani M, et al. FEBS Lett, 1993 Jul 12. PMID 7686862
  4. Combined apoptosis and autophagy, the process that eliminates the oocytes of atretic follicles in immature rats. Escobar ML, et al. Apoptosis, 2008 Oct. PMID 18690537
  5. Kinetic studies on rat liver low M(r) phosphotyrosine protein phosphatases. The activation mechanism of the isoenzyme AcP2 by cGMP. Cirri P, et al. Biochim Biophys Acta, 1995 Jan 18. PMID 7827101

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables acid phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acid phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables acid phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphoprotein phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphotyrosine residue binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in autophagic cell death IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chemical synaptic transmission NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in lysosome organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lysosome organization ISO
Inferred from Sequence Orthology
more info
  
involved_in response to cGMP IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within skeletal system development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in lysosomal lumen IEA
Inferred from Electronic Annotation
more info
  
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosome ISO
Inferred from Sequence Orthology
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
lysosomal acid phosphatase
Names
Acid phosphatase 2, lysozymal
LMW-PTP-II low molecular weight phosphotyrosine protein phosphatase isozyme 2
NP_001344000.1
NP_058684.2
XP_006234562.1
XP_063139142.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357071.1 → NP_001344000.1  lysosomal acid phosphatase isoform 1x precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UAG termination codon. This RefSeq represents the longer isoform (1x). As the UGA stop codon has been reported to specify several alternative amino acids (tryptophan, cysteine, arginine and serine), its location in the longer isoform is denoted by an 'X'.
    Source sequence(s)
    BC081823, CB720349
    UniProtKB/Swiss-Prot
    P20611
    Conserved Domains (1) summary
    cd07061
    Location:33 → 330
    HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction

  2. NM_016988.2 → NP_058684.2  lysosomal acid phosphatase isoform 1 precursor

    See identical proteins and their annotated locations for NP_058684.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UAG termination codon. This RefSeq represents the shorter isoform (1).
    Source sequence(s)
    BC081823, CB720349
    UniProtKB/Swiss-Prot
    P20611
    UniProtKB/TrEMBL
    Q642D2
    Conserved Domains (1) summary
    cd07061
    Location:33 → 330
    HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    97630654..97642601
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063283072.1 → XP_063139142.1  lysosomal acid phosphatase isoform X1

    Related
    ENSRNOP00000105616.1, ENSRNOT00000123449.1

  2. XM_006234500.4 → XP_006234562.1  lysosomal acid phosphatase isoform X2

    See identical proteins and their annotated locations for XP_006234562.1

    UniProtKB/TrEMBL
    A0A8I5ZST8, A6HNB5, F7F1A3
    Related
    ENSRNOP00000018620.3, ENSRNOT00000018620.6
    Conserved Domains (1) summary
    cd07061
    Location:69 → 366
    HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P20611.1 GenPept UniProtKB/Swiss-Prot:P20611

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