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Kcng1 potassium voltage-gated channel, subfamily G, member 1 [ Mus musculus (house mouse) ]

Gene ID: 241794, updated on 2-Nov-2024

Summary

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Official Symbol
Kcng1provided by MGI
Official Full Name
potassium voltage-gated channel, subfamily G, member 1provided by MGI
Primary source
MGI:MGI:3616086
See related
Ensembl:ENSMUSG00000074575 AllianceGenome:MGI:3616086
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable delayed rectifier potassium channel activity and potassium channel regulator activity. Predicted to be involved in action potential; potassium ion transmembrane transport; and regulation of potassium ion transmembrane transport. Predicted to be located in plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in membrane. Orthologous to human KCNG1 (potassium voltage-gated channel modifier subfamily G member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in bladder adult (RPKM 3.0), testis adult (RPKM 2.6) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Kcng1 in Genome Data Viewer
Location:
2 H3; 2 88.55 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (168102037..168123453, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (168260117..168281533, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_06458 Neighboring gene molybdenum cofactor synthesis 3 Neighboring gene STARR-positive B cell enhancer mm9_chr2:168075791-168076092 Neighboring gene 28S ribosomal protein S18c, mitochondrial pseudogene Neighboring gene predicted gene, 33262 Neighboring gene predicted gene, 22704 Neighboring gene predicted gene, 39992

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  2. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables delayed rectifier potassium channel activity ISO
Inferred from Sequence Orthology
more info
  
enables potassium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables potassium channel regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables voltage-gated potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in action potential IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in potassium ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in potassium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein homooligomerization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of potassium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of voltage-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
  
part_of voltage-gated potassium channel complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
voltage-gated potassium channel regulatory subunit KCNG1
Names
orthologue of H. sapiens potassium voltage-gated channel, subfamily G, member 1 (KCNG1)
voltage-gated potassium channel subunit Kv6.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081134.2 → NP_001074603.1  voltage-gated potassium channel regulatory subunit KCNG1

    See identical proteins and their annotated locations for NP_001074603.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    BX005039
    Consensus CDS
    CCDS38344.1
    UniProtKB/Swiss-Prot
    A2BDX4
    UniProtKB/TrEMBL
    B2RVK9
    Related
    ENSMUSP00000104815.2, ENSMUST00000109191.2
    Conserved Domains (2) summary
    cd18421
    Location:60 → 173
    BTB_POZ_KCNG1_2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily G members, KCNG1 and KCNG2
    pfam00520
    Location:227 → 471
    Ion_trans; Ion transport protein

  2. NM_001379458.1 → NP_001366387.1  voltage-gated potassium channel regulatory subunit KCNG1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    BX005039
    UniProtKB/Swiss-Prot
    A2BDX4
    UniProtKB/TrEMBL
    B2RVK9
    Related
    ENSMUSP00000096668.3, ENSMUST00000099069.3
    Conserved Domains (2) summary
    cd18421
    Location:60 → 173
    BTB_POZ_KCNG1_2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily G members, KCNG1 and KCNG2
    pfam00520
    Location:227 → 471
    Ion_trans; Ion transport protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    168102037..168123453 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2BDX4.1 GenPept UniProtKB/Swiss-Prot:A2BDX4

Gene LinkOut

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