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Lrit3 leucine-rich repeat, immunoglobulin-like and transmembrane domains 3 [ Mus musculus (house mouse) ]

Gene ID: 242235, updated on 2-Nov-2024

Summary

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Official Symbol
Lrit3provided by MGI
Official Full Name
leucine-rich repeat, immunoglobulin-like and transmembrane domains 3provided by MGI
Primary source
MGI:MGI:2685267
See related
Ensembl:ENSMUSG00000093865 AllianceGenome:MGI:2685267
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm421
Summary
Acts upstream of or within several processes, including synapse assembly involved in innervation; synaptic signaling; and visual perception. Is active in cell tip and dendrite. Used to study congenital stationary night blindness 1F. Human ortholog(s) of this gene implicated in congenital stationary night blindness 1F. Orthologous to human LRIT3 (leucine rich repeat, Ig-like and transmembrane domains 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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See Lrit3 in Genome Data Viewer
Location:
3 G3; 3 58.99 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (129577590..129597785, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (129783941..129804136, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E827 Neighboring gene STARR-seq mESC enhancer starr_08971 Neighboring gene STARR-seq mESC enhancer starr_08975 Neighboring gene STARR-seq mESC enhancer starr_08976 Neighboring gene predicted gene, 35986 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:129256142-129256329 Neighboring gene ELOVL fatty acid elongase 6 Neighboring gene STARR-seq mESC enhancer starr_08981 Neighboring gene epidermal growth factor Neighboring gene STARR-positive B cell enhancer ABC_E6124 Neighboring gene RIKEN cDNA 6330410L21 gene Neighboring gene predicted gene, 36130 Neighboring gene STARR-positive B cell enhancer ABC_E7942 Neighboring gene retinal pigment epithelium derived rhodopsin homolog Neighboring gene GAR1 ribonucleoprotein Neighboring gene predicted gene, 36180 Neighboring gene complement component factor i

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Presynaptic Expression of LRIT3 Transsynaptically Organizes the Postsynaptic Glutamate Signaling Complex Containing TRPM1. Hasan N, et al. Cell Rep, 2019 Jun 11. PMID 31189098, Free PMC Article
  2. LRIT3 Differentially Affects Connectivity and Synaptic Transmission of Cones to ON- and OFF-Bipolar Cells. Neuillé M, et al. Invest Ophthalmol Vis Sci, 2017 Mar 1. PMID 28334377, Free PMC Article
  3. Lrit3 deficient mouse (nob6): a novel model of complete congenital stationary night blindness (cCSNB). Neuillé M, et al. PLoS One, 2014. PMID 24598786, Free PMC Article
  4. A Chemical Mutagenesis Screen Identifies Mouse Models with ERG Defects. Charette JR, et al. Adv Exp Med Biol, 2016. PMID 26427409, Free PMC Article
  5. Leucine-rich repeat, immunoglobulin-like and transmembrane domain 3 (LRIT3) is a modulator of FGFR1. Kim SD, et al. FEBS Lett, 2012 May 21. PMID 22673519, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LRIT3 is Required for Nyctalopin Expression and Normal ON and OFF Pathway Signaling in the Retina.
    Title: LRIT3 is Required for Nyctalopin Expression and Normal ON and OFF Pathway Signaling in the Retina.
  2. LRIT3 is expressed in rod photoreceptors and acts transsynaptically to localize the TRPM1 channel in the postsynaptic membrane.
    Title: Presynaptic Expression of LRIT3 Transsynaptically Organizes the Postsynaptic Glutamate Signaling Complex Containing TRPM1.
  3. This study confirmed the localization of LRIT3 at the dendritic tips of depolarizing bipolar cells in mouse retina and demonstrated the dependence of TRPM1 localization on the presence of LRIT3.
    Title: LRIT3 is essential to localize TRPM1 to the dendritic tips of depolarizing bipolar cells and may play a role in cone synapse formation.
  4. The stationary no b-wave phenotype of mice lacking Lrit3, which we named nob6, confirms the findings previously reported in patients carrying LRIT3 mutations.
    Title: Lrit3 deficient mouse (nob6): a novel model of complete congenital stationary night blindness (cCSNB).
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of fibroblast growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of fibroblast growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to light stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within synapse assembly involved in innervation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within synaptic signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within visual perception IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell tip IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001287224.2 → NP_001274153.1  leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3 precursor

    See identical proteins and their annotated locations for NP_001274153.1

    Status: VALIDATED

    Source sequence(s)
    AC111097
    Consensus CDS
    CCDS57256.2
    UniProtKB/Swiss-Prot
    W8DXL4
    UniProtKB/TrEMBL
    J3QNQ8
    Related
    ENSMUSP00000140184.2, ENSMUST00000185462.7
    Conserved Domains (6) summary
    smart00410
    Location:263 → 339
    IG_like; Immunoglobulin like
    cd00063
    Location:489 → 563
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    sd00031
    Location:83 → 106
    LRR_1; leucine-rich repeat [structural motif]
    pfam12799
    Location:129 → 170
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:105 → 165
    LRR_8; Leucine rich repeat
    cl11960
    Location:254 → 335
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    129577590..129597785 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001205102.1: Suppressed sequence

    Description
    NM_001205102.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
W8DXL4.1 GenPept UniProtKB/Swiss-Prot:W8DXL4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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