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Calm3 calmodulin 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24244, updated on 2-Nov-2024

Summary

Official Symbol
Calm3provided by RGD
Official Full Name
calmodulin 3provided by RGD
Primary source
RGD:2259
See related
EnsemblRapid:ENSRNOG00000016770 AllianceGenome:RGD:2259
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cam3; Camc; CaMIII; RNCAMIII
Summary
Enables several functions, including nitric-oxide synthase binding activity; nitric-oxide synthase regulator activity; and transmembrane transporter binding activity. Involved in several processes, including positive regulation of nitric-oxide synthase activity; regulation of calcium ion transmembrane transporter activity; and regulation of vesicle-mediated transport. Located in several cellular components, including growth cone; myelin sheath; and synaptic vesicle membrane. Is active in Schaffer collateral - CA1 synapse; postsynaptic cytosol; and presynaptic cytosol. Human ortholog(s) of this gene implicated in familial hypertrophic cardiomyopathy and long QT syndrome 16. Orthologous to human CALM3 (calmodulin 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 5620.8), Muscle (RPKM 1913.6) and 9 other tissues See more
Orthologs
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Genomic context

See Calm3 in Genome Data Viewer
Location:
1q21
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (86718761..86725869, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (77590668..77597776, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (78844520..78851628, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene G protein subunit gamma 8 Neighboring gene prostaglandin I2 receptor Neighboring gene PNMA family member 8B Neighboring gene 60S ribosomal protein L32 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables adenylate cyclase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables adenylate cyclase binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium channel inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables calcium channel inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables nitric-oxide synthase binding IDA
Inferred from Direct Assay
more info
PubMed 
enables nitric-oxide synthase regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein phosphatase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables titin binding ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane transporter binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in autophagosome membrane docking ISO
Inferred from Sequence Orthology
more info
 
involved_in autophagosome membrane docking ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to interferon-beta ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to type II interferon ISO
Inferred from Sequence Orthology
more info
 
involved_in detection of calcium ion ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of localization in cell IEA
Inferred from Electronic Annotation
more info
 
involved_in establishment of protein localization to membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment of protein localization to mitochondrial membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitochondrion-endoplasmic reticulum membrane tethering ISO
Inferred from Sequence Orthology
more info
 
involved_in mitochondrion-endoplasmic reticulum membrane tethering ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of high voltage-gated calcium channel activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of high voltage-gated calcium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of ryanodine-sensitive calcium-release channel activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of ryanodine-sensitive calcium-release channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in organelle localization by membrane tethering ISO
Inferred from Sequence Orthology
more info
 
involved_in organelle localization by membrane tethering ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cyclic-nucleotide phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of nitric-oxide synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of receptor signaling pathway via JAK-STAT ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ryanodine-sensitive calcium-release channel activity ISO
Inferred from Sequence Orthology
more info
 
involved_in presynaptic endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cardiac muscle cell action potential ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cardiac muscle cell action potential ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cardiac muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of heart rate ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of high voltage-gated calcium channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of ryanodine-sensitive calcium-release channel activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of ryanodine-sensitive calcium-release channel activity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of ryanodine-sensitive calcium-release channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of store-operated calcium channel activity IC
Inferred by Curator
more info
PubMed 
involved_in regulation of synaptic vesicle endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of synaptic vesicle exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to amphetamine IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to calcium ion ISO
Inferred from Sequence Orthology
more info
 
involved_in substantia nigra development ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse NAS
Non-traceable Author Statement
more info
PubMed 
part_of calcium channel complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in calyx of Held ISO
Inferred from Sequence Orthology
more info
 
part_of catalytic complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in distal axon IEA
Inferred from Electronic Annotation
more info
 
located_in growth cone IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in myelin sheath IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in myelin sheath IDA
Inferred from Direct Assay
more info
PubMed 
located_in myelin sheath IEA
Inferred from Electronic Annotation
more info
 
located_in myelin sheath ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in postsynaptic cytosol IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic cytosol NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in presynaptic cytosol IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in presynaptic cytosol NAS
Non-traceable Author Statement
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in sarcomere ISO
Inferred from Sequence Orthology
more info
 
located_in spindle microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in spindle pole IEA
Inferred from Electronic Annotation
more info
 
located_in spindle pole ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic vesicle membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of voltage-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
calmodulin-3
Names
Calmodulin III
caM
NP_036650.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012518.3NP_036650.1  calmodulin-3

    See identical proteins and their annotated locations for NP_036650.1

    Status: PROVISIONAL

    Source sequence(s)
    M16659
    UniProtKB/Swiss-Prot
    P0DP29, P0DP30, P0DP31, P62161
    UniProtKB/TrEMBL
    A0A8I5XV89, A6JEH0
    Related
    ENSRNOP00000103420.1, ENSRNOT00000124429.1
    Conserved Domains (1) summary
    PTZ00184
    Location:1149
    PTZ00184; calmodulin; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    86718761..86725869 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)