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Cgm4 carcinoembryonic antigen gene family 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24257, updated on 2-Nov-2024

Summary

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Official Symbol
Cgm4provided by RGD
Official Full Name
carcinoembryonic antigen gene family 4provided by RGD
Primary source
RGD:1307652
See related
EnsemblRapid:ENSRNOG00000062787 AllianceGenome:RGD:1307652
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cea; CEA4; CEA5; Cear; Psg16; CGM4AA
Summary
Predicted to enable protein tyrosine kinase binding activity. Predicted to be involved in regulation of immune system process and signal transduction. Predicted to be active in cell surface and plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward (RPKM 1.9) See more
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Genomic context

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See Cgm4 in Genome Data Viewer
Location:
1q21
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (86904526..86917487)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (77776447..77789408)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (79030291..79043259)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene protein phosphatase 5, catalytic subunit Neighboring gene hypoxia inducible factor 3 subunit alpha Neighboring gene pregnancy specific glycoprotein 16 Neighboring gene CEA cell adhesion molecule 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. cDNA and gene analyses imply a novel structure for a rat carcinoembryonic antigen-related protein. Rebstock S, et al. J Biol Chem, 1990 May 15. PMID 2335509
  2. Identification of a carcinoembryonic antigen gene family in the rat. Analysis of the N-terminal domains reveals immunoglobulin-like, hypervariable regions. Kodelja V, et al. J Biol Chem, 1989 Apr 25. PMID 2708349
  3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein tyrosine kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of immune system process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
carcinoembryonic antigen gene family 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012525.1 → NP_036657.1  carcinoembryonic antigen gene family 4 precursor

    See identical proteins and their annotated locations for NP_036657.1

    Status: VALIDATED

    Source sequence(s)
    AA818022, BI283810, BI285964, CB706316, CB766157, CB786391, CB804911, CV118170
    UniProtKB/TrEMBL
    Q4V8J0
    Related
    ENSRNOP00000033854.4, ENSRNOT00000037086.8
    Conserved Domains (3) summary
    cd05774
    Location:157 → 261
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:396 → 473
    IG_like; Immunoglobulin like
    cl11960
    Location:383 → 473
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    86904526..86917487
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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